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Pharmacological properties and mechanisms of Notoginsenoside R1 in ischemia-reperfusion injury

Panax notoginseng is an ancient Chinese medicinal plant that has great clinical value in regulating cardiovascular disease in China. As a single component of panax notoginosides, notoginsenoside R1 (NGR1) belongs to the panaxatriol group. Many reports have demonstrated that NGR1 exerts multiple phar...

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Autores principales: Zhu, Ting, Wan, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912185/
https://www.ncbi.nlm.nih.gov/pubmed/35922249
http://dx.doi.org/10.1016/j.cjtee.2022.06.008
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author Zhu, Ting
Wan, Qi
author_facet Zhu, Ting
Wan, Qi
author_sort Zhu, Ting
collection PubMed
description Panax notoginseng is an ancient Chinese medicinal plant that has great clinical value in regulating cardiovascular disease in China. As a single component of panax notoginosides, notoginsenoside R1 (NGR1) belongs to the panaxatriol group. Many reports have demonstrated that NGR1 exerts multiple pharmacological effects in ischemic stroke, myocardial infarction, acute renal injury, and intestinal injury. Here, we outline the available reports on the pharmacological effects of NGR1 in ischemia-reperfusion (I/R) injury. We also discuss the chemistry, composition and molecular mechanism underlying the anti-I/R injury effects of NGR1. NGR1 had significant effects on reducing cerebral infarct size and neurological deficits in cerebral I/R injury, ameliorating the impaired mitochondrial morphology in myocardial I/R injury, decreasing kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin in renal I/R injury and attenuating jejunal mucosal epithelium injury in intestinal I/R injury. The various organ anti-I/R injury effects of NGR1 are mainly through the suppression of oxidative stress, apoptosis, inflammation, endoplasmic reticulum stress and promotion of angiogenesis and neurogenesis. These findings provide a reference basis for future research of NGR1 on I/R injury.
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spelling pubmed-99121852023-02-11 Pharmacological properties and mechanisms of Notoginsenoside R1 in ischemia-reperfusion injury Zhu, Ting Wan, Qi Chin J Traumatol Mini-Review Panax notoginseng is an ancient Chinese medicinal plant that has great clinical value in regulating cardiovascular disease in China. As a single component of panax notoginosides, notoginsenoside R1 (NGR1) belongs to the panaxatriol group. Many reports have demonstrated that NGR1 exerts multiple pharmacological effects in ischemic stroke, myocardial infarction, acute renal injury, and intestinal injury. Here, we outline the available reports on the pharmacological effects of NGR1 in ischemia-reperfusion (I/R) injury. We also discuss the chemistry, composition and molecular mechanism underlying the anti-I/R injury effects of NGR1. NGR1 had significant effects on reducing cerebral infarct size and neurological deficits in cerebral I/R injury, ameliorating the impaired mitochondrial morphology in myocardial I/R injury, decreasing kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin in renal I/R injury and attenuating jejunal mucosal epithelium injury in intestinal I/R injury. The various organ anti-I/R injury effects of NGR1 are mainly through the suppression of oxidative stress, apoptosis, inflammation, endoplasmic reticulum stress and promotion of angiogenesis and neurogenesis. These findings provide a reference basis for future research of NGR1 on I/R injury. Elsevier 2023-01 2022-07-03 /pmc/articles/PMC9912185/ /pubmed/35922249 http://dx.doi.org/10.1016/j.cjtee.2022.06.008 Text en © 2023 Production and hosting by Elsevier B.V. on behalf of Chinese Medical Association. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Mini-Review
Zhu, Ting
Wan, Qi
Pharmacological properties and mechanisms of Notoginsenoside R1 in ischemia-reperfusion injury
title Pharmacological properties and mechanisms of Notoginsenoside R1 in ischemia-reperfusion injury
title_full Pharmacological properties and mechanisms of Notoginsenoside R1 in ischemia-reperfusion injury
title_fullStr Pharmacological properties and mechanisms of Notoginsenoside R1 in ischemia-reperfusion injury
title_full_unstemmed Pharmacological properties and mechanisms of Notoginsenoside R1 in ischemia-reperfusion injury
title_short Pharmacological properties and mechanisms of Notoginsenoside R1 in ischemia-reperfusion injury
title_sort pharmacological properties and mechanisms of notoginsenoside r1 in ischemia-reperfusion injury
topic Mini-Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912185/
https://www.ncbi.nlm.nih.gov/pubmed/35922249
http://dx.doi.org/10.1016/j.cjtee.2022.06.008
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