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The Association between Vitamin D and the Components of Male Fertility: A Systematic Review

Objective: Previous systematic reviews of the effects of vitamin D on the components of male fertility have been inconclusive. This article systematically reviews the latest research to examine the relationship between vitamin D, semen quality parameters, and sex hormones production. Methods: MEDLIN...

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Autores principales: Adamczewska, Daria, Słowikowska-Hilczer, Jolanta, Walczak-Jędrzejowska, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912266/
https://www.ncbi.nlm.nih.gov/pubmed/36672602
http://dx.doi.org/10.3390/biomedicines11010090
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author Adamczewska, Daria
Słowikowska-Hilczer, Jolanta
Walczak-Jędrzejowska, Renata
author_facet Adamczewska, Daria
Słowikowska-Hilczer, Jolanta
Walczak-Jędrzejowska, Renata
author_sort Adamczewska, Daria
collection PubMed
description Objective: Previous systematic reviews of the effects of vitamin D on the components of male fertility have been inconclusive. This article systematically reviews the latest research to examine the relationship between vitamin D, semen quality parameters, and sex hormones production. Methods: MEDLINE, Cochrane, and Web of Science databases were searched using the appropriate keywords. Results: Observational studies indicate significant correlation between vitamin D levels and sperm parameters, with a particular emphasis on sperm motility, and partially suggest a relationship between higher serum testosterone and vitamin D levels. Additionally, interventional studies confirmed that vitamin D supplementation has a positive effect on sperm motility, especially progressive. However, most randomized clinical trials indicate that vitamin D treatment does not have any significant effect on testosterone or other hormone levels. Conclusions: Although our findings add to the discussion regarding the effect of vitamin D on male fertility, there is still no solid evidence to support the use of vitamin D supplementation to improve the outcomes of patients with impaired sperm parameters and hormonal disorders. Additional dedicated clinical studies are needed to clarify the relationship between vitamin D and male fertility, along with its components.
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spelling pubmed-99122662023-02-11 The Association between Vitamin D and the Components of Male Fertility: A Systematic Review Adamczewska, Daria Słowikowska-Hilczer, Jolanta Walczak-Jędrzejowska, Renata Biomedicines Systematic Review Objective: Previous systematic reviews of the effects of vitamin D on the components of male fertility have been inconclusive. This article systematically reviews the latest research to examine the relationship between vitamin D, semen quality parameters, and sex hormones production. Methods: MEDLINE, Cochrane, and Web of Science databases were searched using the appropriate keywords. Results: Observational studies indicate significant correlation between vitamin D levels and sperm parameters, with a particular emphasis on sperm motility, and partially suggest a relationship between higher serum testosterone and vitamin D levels. Additionally, interventional studies confirmed that vitamin D supplementation has a positive effect on sperm motility, especially progressive. However, most randomized clinical trials indicate that vitamin D treatment does not have any significant effect on testosterone or other hormone levels. Conclusions: Although our findings add to the discussion regarding the effect of vitamin D on male fertility, there is still no solid evidence to support the use of vitamin D supplementation to improve the outcomes of patients with impaired sperm parameters and hormonal disorders. Additional dedicated clinical studies are needed to clarify the relationship between vitamin D and male fertility, along with its components. MDPI 2022-12-29 /pmc/articles/PMC9912266/ /pubmed/36672602 http://dx.doi.org/10.3390/biomedicines11010090 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Adamczewska, Daria
Słowikowska-Hilczer, Jolanta
Walczak-Jędrzejowska, Renata
The Association between Vitamin D and the Components of Male Fertility: A Systematic Review
title The Association between Vitamin D and the Components of Male Fertility: A Systematic Review
title_full The Association between Vitamin D and the Components of Male Fertility: A Systematic Review
title_fullStr The Association between Vitamin D and the Components of Male Fertility: A Systematic Review
title_full_unstemmed The Association between Vitamin D and the Components of Male Fertility: A Systematic Review
title_short The Association between Vitamin D and the Components of Male Fertility: A Systematic Review
title_sort association between vitamin d and the components of male fertility: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912266/
https://www.ncbi.nlm.nih.gov/pubmed/36672602
http://dx.doi.org/10.3390/biomedicines11010090
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