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Advancing Targeted Protein Degradation via Multiomics Profiling and Artificial Intelligence
[Image: see text] Only around 20% of the human proteome is considered to be druggable with small-molecule antagonists. This leaves some of the most compelling therapeutic targets outside the reach of ligand discovery. The concept of targeted protein degradation (TPD) promises to overcome some of the...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912273/ https://www.ncbi.nlm.nih.gov/pubmed/36706315 http://dx.doi.org/10.1021/jacs.2c11098 |