Common molecular features of H3K27M DMGs and PFA ependymomas map to hindbrain developmental pathways

Globally decreased histone 3, lysine 27 tri-methylation (H3K27me3) is a hallmark of H3K27-altered diffuse midline gliomas (DMGs) and group-A posterior fossa ependymomas (PFAs). H3K27-altered DMGs are largely characterized by lysine-to-methionine mutations in histone 3 at position 27 (H3K27M). Most P...

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Detalles Bibliográficos
Autores principales: Pun, Matthew, Pratt, Drew, Nano, Patricia R., Joshi, Piyush K., Jiang, Li, Englinger, Bernhard, Rao, Arvind, Cieslik, Marcin, Chinnaiyan, Arul M., Aldape, Kenneth, Pfister, Stefan, Filbin, Mariella G., Bhaduri, Aparna, Venneti, Sriram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912509/
https://www.ncbi.nlm.nih.gov/pubmed/36759899
http://dx.doi.org/10.1186/s40478-023-01514-z

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