Mutation-class dependent signatures outweigh disease-associated processes in cystic fibrosis cells

BACKGROUND: The phenotypic heterogeneity observed in Cystic Fibrosis (CF) patients suggests the involvement of other genes, besides CFTR. Here, we combined transcriptome and proteome analysis to understand the global gene expression patterns associated with five prototypical CFTR mutations. RESULTS:...

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Detalles Bibliográficos
Autores principales: Santos, Lúcia, Nascimento, Rui, Duarte, Aires, Railean, Violeta, Amaral, Margarida D., Harrison, Patrick T., Gama-Carvalho, Margarida, Farinha, Carlos M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912517/
https://www.ncbi.nlm.nih.gov/pubmed/36759923
http://dx.doi.org/10.1186/s13578-023-00975-y

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