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The Role of Lactate for Sepsis in Polytrauma Patients, a Time related Analysis using the IBM Watson Trauma Pathway Explorer(®)

The Watson Trauma Pathway Explorer(®) is an outcome prediction tool invented by the University Hospital of Zurich in collaboration with IBM(®), representing an artificial intelligence application to predict the most adverse outcome scenarios in polytrauma patients: Systemic Inflammatory Respiratory...

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Detalles Bibliográficos
Autores principales: Vetter, Philipp, Niggli, Cédric, Hambrecht, Jan, Niggli, Philipp, Vomela, Jindrich, Chaloupka, Richard, Pape, Hans-Christoph, Mica, Ladislav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912541/
https://www.ncbi.nlm.nih.gov/pubmed/36777916
http://dx.doi.org/10.26502/jsr.10020268
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author Vetter, Philipp
Niggli, Cédric
Hambrecht, Jan
Niggli, Philipp
Vomela, Jindrich
Chaloupka, Richard
Pape, Hans-Christoph
Mica, Ladislav
author_facet Vetter, Philipp
Niggli, Cédric
Hambrecht, Jan
Niggli, Philipp
Vomela, Jindrich
Chaloupka, Richard
Pape, Hans-Christoph
Mica, Ladislav
author_sort Vetter, Philipp
collection PubMed
description The Watson Trauma Pathway Explorer(®) is an outcome prediction tool invented by the University Hospital of Zurich in collaboration with IBM(®), representing an artificial intelligence application to predict the most adverse outcome scenarios in polytrauma patients: Systemic Inflammatory Respiratory Syndrome (SIRS), sepsis within 21 days and death within 72 h. The hypothesis was how lactate values woud be associated with the incidence of sepsis. Data from 3653 patients in an internal database, with ongoing implementation, served for analysis. Patients were split in two groups according to sepsis presence, and lactate values were measured at formerly defined time points from admission until 21 days after admission for both groups. Differences between groups were analyzed; time points with lactate as independent predictor for sepsis were identified. The predictive quality of lactate at 2 and 12 h after admission was evaluated. Threshold values between groups at all timepoints were calculated. Lactate levels differed from less than 2 h after admission until the end of the observation period (21 d). Lactate represented an independent predictor for sepsis from 12 to 48 h and 14 d to 21 d after admission relative to ISS levels. AUROC was poor at 2 and 12 h after admission with a slight improvement at the 12 h mark. Lactate levels decreased over time at a range of 2 [mmol/L] for 6–8 h after admission. These insights may allow for time-dependent referencing of lactate levels and anticipation of subsequent sepsis, although further parameters must be considered for a higher predictability.
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spelling pubmed-99125412023-02-10 The Role of Lactate for Sepsis in Polytrauma Patients, a Time related Analysis using the IBM Watson Trauma Pathway Explorer(®) Vetter, Philipp Niggli, Cédric Hambrecht, Jan Niggli, Philipp Vomela, Jindrich Chaloupka, Richard Pape, Hans-Christoph Mica, Ladislav J Surg Res (Houst) Article The Watson Trauma Pathway Explorer(®) is an outcome prediction tool invented by the University Hospital of Zurich in collaboration with IBM(®), representing an artificial intelligence application to predict the most adverse outcome scenarios in polytrauma patients: Systemic Inflammatory Respiratory Syndrome (SIRS), sepsis within 21 days and death within 72 h. The hypothesis was how lactate values woud be associated with the incidence of sepsis. Data from 3653 patients in an internal database, with ongoing implementation, served for analysis. Patients were split in two groups according to sepsis presence, and lactate values were measured at formerly defined time points from admission until 21 days after admission for both groups. Differences between groups were analyzed; time points with lactate as independent predictor for sepsis were identified. The predictive quality of lactate at 2 and 12 h after admission was evaluated. Threshold values between groups at all timepoints were calculated. Lactate levels differed from less than 2 h after admission until the end of the observation period (21 d). Lactate represented an independent predictor for sepsis from 12 to 48 h and 14 d to 21 d after admission relative to ISS levels. AUROC was poor at 2 and 12 h after admission with a slight improvement at the 12 h mark. Lactate levels decreased over time at a range of 2 [mmol/L] for 6–8 h after admission. These insights may allow for time-dependent referencing of lactate levels and anticipation of subsequent sepsis, although further parameters must be considered for a higher predictability. 2022 2022-12-05 /pmc/articles/PMC9912541/ /pubmed/36777916 http://dx.doi.org/10.26502/jsr.10020268 Text en https://creativecommons.org/licenses/by/4.0/This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license 4.0 (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Article
Vetter, Philipp
Niggli, Cédric
Hambrecht, Jan
Niggli, Philipp
Vomela, Jindrich
Chaloupka, Richard
Pape, Hans-Christoph
Mica, Ladislav
The Role of Lactate for Sepsis in Polytrauma Patients, a Time related Analysis using the IBM Watson Trauma Pathway Explorer(®)
title The Role of Lactate for Sepsis in Polytrauma Patients, a Time related Analysis using the IBM Watson Trauma Pathway Explorer(®)
title_full The Role of Lactate for Sepsis in Polytrauma Patients, a Time related Analysis using the IBM Watson Trauma Pathway Explorer(®)
title_fullStr The Role of Lactate for Sepsis in Polytrauma Patients, a Time related Analysis using the IBM Watson Trauma Pathway Explorer(®)
title_full_unstemmed The Role of Lactate for Sepsis in Polytrauma Patients, a Time related Analysis using the IBM Watson Trauma Pathway Explorer(®)
title_short The Role of Lactate for Sepsis in Polytrauma Patients, a Time related Analysis using the IBM Watson Trauma Pathway Explorer(®)
title_sort role of lactate for sepsis in polytrauma patients, a time related analysis using the ibm watson trauma pathway explorer(®)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912541/
https://www.ncbi.nlm.nih.gov/pubmed/36777916
http://dx.doi.org/10.26502/jsr.10020268
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