Pervasiveness of HLA allele-specific expression loss across tumor types

BACKGROUND: Efficient presentation of mutant peptide fragments by the human leukocyte antigen class I (HLA-I) genes is necessary for immune-mediated killing of cancer cells. According to recent reports, patient HLA-I genotypes can impact the efficacy of cancer immunotherapy, and the somatic loss of...

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Detalles Bibliográficos
Autores principales: Filip, Ioan, Wang, Anqi, Kravets, Oleksandr, Orenbuch, Rose, Zhao, Junfei, Perea-Chamblee, Tomin E., Manji, Gulam A., López de Maturana, Evangelina, Malats, Núria, Olive, Kenneth P., Rabadan, Raul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912643/
https://www.ncbi.nlm.nih.gov/pubmed/36759885
http://dx.doi.org/10.1186/s13073-023-01154-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912643/
https://www.ncbi.nlm.nih.gov/pubmed/36759885
http://dx.doi.org/10.1186/s13073-023-01154-x

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