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“Two birds with one stone” strategy for the lung cancer therapy with bioinspired AIE aggregates
Aggregation-induced emission luminogens (AIEgens) have emerged as novel phototherapeutic agents with high photostability and excellent performance to induce photodynamic and/or photothermal effects. In this study, a zwitterion-type NIR AIEgens C(41)H(37)N(2)O(3)S(2) (named BITT) with biomimetic modi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912660/ https://www.ncbi.nlm.nih.gov/pubmed/36759822 http://dx.doi.org/10.1186/s12951-023-01799-1 |
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author | Lin, Yinshan Yi, Mengmeng Guan, Xiaoling Chen, Enen Yang, Langyu Li, Songpei Li, Ying Zhang, Lingmin |
author_facet | Lin, Yinshan Yi, Mengmeng Guan, Xiaoling Chen, Enen Yang, Langyu Li, Songpei Li, Ying Zhang, Lingmin |
author_sort | Lin, Yinshan |
collection | PubMed |
description | Aggregation-induced emission luminogens (AIEgens) have emerged as novel phototherapeutic agents with high photostability and excellent performance to induce photodynamic and/or photothermal effects. In this study, a zwitterion-type NIR AIEgens C(41)H(37)N(2)O(3)S(2) (named BITT) with biomimetic modification was utilized for lung cancer therapy. The tumor-associated macrophage (TAM)-specific peptide (CRV) was engineered into the lung cancer cell-derived exosomes. The CRV-engineered exosome membranes (CRV-EM) were obtained to camouflage the BITT nanoparticles (CEB), which targeted both lung cancer cells and TAMs through homotypic targeting and TAM-specific peptide, respectively. The camouflage with CRV-EM ameliorated the surface function of BITT nanoparticles, which facilitated the cellular uptake in both cell lines and induced significant cell death in the presence of laser irradiations in vitro and in vivo. CEB showed improved circulation lifetime and accumulations in the tumor tissues in vivo, which induced efficient photodynamic and photothermal therapy. In addition, CEB induced the tumor microenvironment remodeling as indicated by the increase of CD8 + and CD4 + T cells, as well as a decrease of M2 TAM and Myeloid-derived suppressor cells (MDSCs). Our work developed a novel style of bioinspired AIE aggregates, which could eliminate both lung cancer cells and TAMs, and remodel the tumor environments to achieve an efficient lung cancer therapy. To the best of our knowledge, we are the first to use this style of bioinspired AIE aggregates for photo-mediated immunotherapy in lung cancer therapy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-023-01799-1. |
format | Online Article Text |
id | pubmed-9912660 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-99126602023-02-11 “Two birds with one stone” strategy for the lung cancer therapy with bioinspired AIE aggregates Lin, Yinshan Yi, Mengmeng Guan, Xiaoling Chen, Enen Yang, Langyu Li, Songpei Li, Ying Zhang, Lingmin J Nanobiotechnology Research Aggregation-induced emission luminogens (AIEgens) have emerged as novel phototherapeutic agents with high photostability and excellent performance to induce photodynamic and/or photothermal effects. In this study, a zwitterion-type NIR AIEgens C(41)H(37)N(2)O(3)S(2) (named BITT) with biomimetic modification was utilized for lung cancer therapy. The tumor-associated macrophage (TAM)-specific peptide (CRV) was engineered into the lung cancer cell-derived exosomes. The CRV-engineered exosome membranes (CRV-EM) were obtained to camouflage the BITT nanoparticles (CEB), which targeted both lung cancer cells and TAMs through homotypic targeting and TAM-specific peptide, respectively. The camouflage with CRV-EM ameliorated the surface function of BITT nanoparticles, which facilitated the cellular uptake in both cell lines and induced significant cell death in the presence of laser irradiations in vitro and in vivo. CEB showed improved circulation lifetime and accumulations in the tumor tissues in vivo, which induced efficient photodynamic and photothermal therapy. In addition, CEB induced the tumor microenvironment remodeling as indicated by the increase of CD8 + and CD4 + T cells, as well as a decrease of M2 TAM and Myeloid-derived suppressor cells (MDSCs). Our work developed a novel style of bioinspired AIE aggregates, which could eliminate both lung cancer cells and TAMs, and remodel the tumor environments to achieve an efficient lung cancer therapy. To the best of our knowledge, we are the first to use this style of bioinspired AIE aggregates for photo-mediated immunotherapy in lung cancer therapy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-023-01799-1. BioMed Central 2023-02-09 /pmc/articles/PMC9912660/ /pubmed/36759822 http://dx.doi.org/10.1186/s12951-023-01799-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Lin, Yinshan Yi, Mengmeng Guan, Xiaoling Chen, Enen Yang, Langyu Li, Songpei Li, Ying Zhang, Lingmin “Two birds with one stone” strategy for the lung cancer therapy with bioinspired AIE aggregates |
title | “Two birds with one stone” strategy for the lung cancer therapy with bioinspired AIE aggregates |
title_full | “Two birds with one stone” strategy for the lung cancer therapy with bioinspired AIE aggregates |
title_fullStr | “Two birds with one stone” strategy for the lung cancer therapy with bioinspired AIE aggregates |
title_full_unstemmed | “Two birds with one stone” strategy for the lung cancer therapy with bioinspired AIE aggregates |
title_short | “Two birds with one stone” strategy for the lung cancer therapy with bioinspired AIE aggregates |
title_sort | “two birds with one stone” strategy for the lung cancer therapy with bioinspired aie aggregates |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912660/ https://www.ncbi.nlm.nih.gov/pubmed/36759822 http://dx.doi.org/10.1186/s12951-023-01799-1 |
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