Cargando…

Translational molecular imaging and drug development in Parkinson’s disease

Parkinson’s disease (PD) is a progressive neurodegenerative disorder that primarily affects elderly people and constitutes a major source of disability worldwide. Notably, the neuropathological hallmarks of PD include nigrostriatal loss and the formation of intracellular inclusion bodies containing...

Descripción completa

Detalles Bibliográficos
Autores principales:	Haider, Ahmed, Elghazawy, Nehal H., Dawood, Alyaa, Gebhard, Catherine, Wichmann, Thomas, Sippl, Wolfgang, Hoener, Marius, Arenas, Ernest, Liang, Steven H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912681/ https://www.ncbi.nlm.nih.gov/pubmed/36759912 http://dx.doi.org/10.1186/s13024-023-00600-z

Ejemplares similares

Development and Validation of [(3)H]OF-NB1 for Preclinical Assessment of GluN1/2B Candidate Drugs
por: Ahmed, Hazem, et al.
Publicado: (2022)

Optical chemosensors for environmental monitoring of toxic metals related to Alzheimer's disease
por: El-Sewify, Islam M., et al.
Publicado: (2022)

Synthesis and Biological Evaluation of Enantiomerically Pure (R)- and (S)-[(18)F]OF-NB1 for Imaging the GluN2B Subunit-Containing NMDA receptors
por: Korff, Marvin, et al.
Publicado: (2023)

Editorial for Special Issue—“Early-Stage Drug Discovery: Advances and Challenges”
por: Sippl, Wolfgang
Publicado: (2023)

Imaging Cholinergic Receptors in the Brain by Positron Emission Tomography
por: Zhang, Jing-Jing, et al.
Publicado: (2023)

Editorial: Application of PROTACs as a Novel Strategy for Drug Discovery
por: Ibrahim, Hany S., et al.
Publicado: (2021)

Postprocessing of molecular docking poses using binding free energy calculations
por: Wichapong, Kanin, et al.
Publicado: (2012)

Mitochondria and Parkinson’s Disease: Clinical, Molecular, and Translational Aspects
por: Borsche, Max, et al.
Publicado: (2021)

Parkinson’s disease and translational research
por: Dinter, Elisabeth, et al.
Publicado: (2020)

NAD(P)H:quinone oxidoreductase 1 inducer activity of some novel anilinoquinazoline derivatives
por: Ghorab, Mostafa M, et al.
Publicado: (2016)

Introducing the Cardiovascular, metabolic and lipoprotein translation section of journal of translational medicine
por: Mehta, Nehal N
Publicado: (2012)

ParaDockS – an open source framework for molecular docking
por: Pippel, Martin, et al.
Publicado: (2012)

ParaDockS - an open-source framework for molecular docking: implementation of target-class-specific scoring methods
por: Scharfe, Michael, et al.
Publicado: (2013)

Molecular docking, molecular dynamics simulations and in vitro screening reveal cefixime and ceftriaxone as GSK3β covalent inhibitors
por: Nassar, Husam, et al.
Publicado: (2023)

The Neuro-Inflammatory-Vascular Circuit: Evidence for a Sex-Dependent Interrelation?
por: Gebhard, Catherine, et al.
Publicado: (2020)

WNT signaling in midbrain dopaminergic neuron development and cell replacement therapies for Parkinson’s disease
por: Arenas, Ernest, et al.
Publicado: (2015)

Interaction Between the Trace Amine-Associated Receptor 1 and the Dopamine D(2) Receptor Controls Cocaine’s Neurochemical Actions
por: Asif-Malik, Aman, et al.
Publicado: (2017)

Opioid‐induced inhibition of the human 5‐HT and noradrenaline transporters in vitro: link to clinical reports of serotonin syndrome
por: Rickli, Anna, et al.
Publicado: (2018)

Molecular tools in drug research — translational medicine
por: Eder, Sandra, et al.
Publicado: (2011)

The Pharmacological Profile of Second Generation Pyrovalerone Cathinones and Related Cathinone Derivative
por: Kolaczynska, Karolina E., et al.
Publicado: (2021)

Pharmacophore Elucidation and Molecular Docking Studies on 5-Phenyl-1-(3-pyridyl)-1H-1,2,4-triazole-3-carboxylic Acid Derivatives as COX-2 Inhibitors
por: Lindner, Marc, et al.
Publicado: (2010)

Sex hormones in SARS-CoV-2 susceptibility: key players or confounders?
por: Lott, Nicola, et al.
Publicado: (2022)

Molecular targets for modulating the protein translation vital to proteostasis and neuron degeneration in Parkinson’s disease
por: Zhou, Zhi Dong, et al.
Publicado: (2019)

PARADOCKS – a framework for molecular docking
por: Pippel, M, et al.
Publicado: (2011)

Detection of Spatial Correlations in Protein Structures and Molecular Complexes
por: Sippl, Manfred J., et al.
Publicado: (2012)

Receptor Interaction Profiles of 4-Alkoxy-Substituted 2,5-Dimethoxyphenethylamines and Related Amphetamines
por: Kolaczynska, Karolina E., et al.
Publicado: (2019)

Receptor Interaction Profiles of 4-Alkoxy-3,5-Dimethoxy-Phenethylamines (Mescaline Derivatives) and Related Amphetamines
por: Kolaczynska, Karolina E., et al.
Publicado: (2022)

The second brain in Parkinson’s disease: fact or fantasy?
por: Yemula, Nehal, et al.
Publicado: (2022)

Direct and residual antimicrobial effect of 2% chlorhexidine gel, double antibiotic paste and chitosan- chlorhexidine nanoparticles as intracanal medicaments against Enterococcus faecalis and Candida albicans in primary molars: an in-vitro study
por: Wassel, Mariem, et al.
Publicado: (2023)

Molecular Imaging of the GABAergic System in Parkinson’s Disease and Atypical Parkinsonisms
por: Terkelsen, Miriam H., et al.
Publicado: (2022)

Deletion of Trace Amine-Associated Receptor 1 Attenuates Behavioral Responses to Caffeine
por: Schwartz, Michael D., et al.
Publicado: (2018)

TAAR1 Expression in Human Macrophages and Brain Tissue: A Potential Novel Facet of MS Neuroinflammation
por: Barnes, David A., et al.
Publicado: (2021)

Parkinson’s disease mouse models in translational research
por: Antony, Paul M. A., et al.
Publicado: (2011)

Translation Imaging in Parkinson’s Disease: Focus on Neuroinflammation
por: Belloli, Sara, et al.
Publicado: (2020)

Parkinson’s Disease and the Gut: Symptoms, Nutrition, and Microbiota
por: Yemula, Nehal, et al.
Publicado: (2021)

COSMOsim3D for drug-similarity, alignment, and molecular field analysis
por: Klamt, Andreas, et al.
Publicado: (2012)

Editorial to Special Issue—“Structure-Activity Relationships (SAR) of Natural Products”
por: Sippl, Wolfgang, et al.
Publicado: (2021)

Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and PDGFR-β related to anticancer drug resistance
por: Fischer, Tim, et al.
Publicado: (2017)

Clinicopathologic Features of Breast Cancer in Egypt—Contemporary Profile and Future Needs: A Systematic Review and Meta-Analysis
por: Azim, Hamdy A., et al.
Publicado: (2023)

Use of the head-twitch response to investigate the structure–activity relationships of 4-thio-substituted 2,5-dimethoxyphenylalkylamines
por: Halberstadt, Adam L., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_3803785c44fmriomlst50i2k9s