Cargando…

Affordable drug resistance genotyping of HIV-1 reverse transcriptase, protease and integrase genes, for resource limited settings

BACKGROUND: As use of dolutegravir (DTG) becomes more common in resource limited settings (RLS), the demand for integrase resistance testing is increasing. Affordable methods for genotyping all relevant HIV-1 pol genes (i.e., protease (PR), reverse transcriptase (RT) and integrase (IN)) are required...

Descripción completa

Detalles Bibliográficos
Autores principales:	Manyana, Sontaga, Pillay, Melendhran, Gounder, Lilishia, Khan, Aabida, Moodley, Pravi, Naidoo, Kogieleum, Chimukangara, Benjamin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912687/ https://www.ncbi.nlm.nih.gov/pubmed/36759801 http://dx.doi.org/10.1186/s12981-023-00505-3

Ejemplares similares

HIV-1 Drug Resistance Genotyping in Resource Limited Settings: Current and Future Perspectives in Sequencing Technologies
por: Manyana, Sontaga, et al.
Publicado: (2021)

HIV-1 Protease, Reverse Transcriptase, and Integrase Variation
por: Rhee, Soo-Yon, et al.
Publicado: (2016)

Seroprevalence of SARS-CoV-2 immunoglobulin G in HIV-positive and HIV-negative individuals in KwaZulu-Natal, South Africa
por: Francois, Kerri-Lee A., et al.
Publicado: (2023)

Coevolved Multidrug-Resistant HIV-1 Protease and Reverse Transcriptase Influences Integrase Drug Susceptibility and Replication Fitness
por: Martin, Supang A., et al.
Publicado: (2021)

Cross-clade simultaneous HIV drug resistance genotyping for reverse transcriptase, protease, and integrase inhibitor mutations by Illumina MiSeq
por: Dudley, Dawn M, et al.
Publicado: (2014)

Reduced efficacy of HIV-1 integrase inhibitors in patients with drug resistance mutations in reverse transcriptase
por: Siedner, Mark J., et al.
Publicado: (2020)

Development of Elvitegravir Resistance and Linkage of Integrase Inhibitor Mutations with Protease and Reverse Transcriptase Resistance Mutations
por: Winters, Mark A., et al.
Publicado: (2012)

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
por: Smith, Steven J., et al.
Publicado: (2014)

Cis-Allosteric Regulation of HIV-1 Reverse Transcriptase by Integrase
por: Masuda, Takao, et al.
Publicado: (2022)

Drug Resistance Mutations Against Protease, Reverse Transcriptase and Integrase Inhibitors in People Living With HIV-1 Receiving Boosted Protease Inhibitors in South Africa
por: Obasa, Adetayo Emmanuel, et al.
Publicado: (2020)

Impact of HIV-1 Subtype and Antiretroviral Therapy on Protease and Reverse Transcriptase Genotype: Results of a Global Collaboration
por: Kantor, Rami, et al.
Publicado: (2005)

A Partially Multiplexed HIV Drug Resistance (HIVDR) Assay for Monitoring HIVDR Mutations of the Protease, Reverse-Transcriptase (PRRT), and Integrase (INT)
por: DeVos, Joshua, et al.
Publicado: (2022)

Long-Acting Anti-HIV Drugs Targeting HIV-1 Reverse Transcriptase and Integrase
por: Singh, Kamal, et al.
Publicado: (2019)

Non-Nucleoside Reverse Transcriptase Inhibitors Join Forces with Integrase Inhibitors to Combat HIV
por: Himmel, Daniel M., et al.
Publicado: (2020)

Structural coordination between active sites of a CRISPR reverse transcriptase-integrase complex
por: Wang, Joy Y., et al.
Publicado: (2021)

Impact of pretreatment low-abundance HIV-1 drug-resistant variants on virological failure among HIV-1/TB-co-infected individuals
por: Chimukangara, Benjamin, et al.
Publicado: (2020)

The Need for Development of New HIV-1 Reverse Transcriptase and Integrase Inhibitors in the Aftermath of Antiviral Drug Resistance
por: Wainberg, Mark A.
Publicado: (2012)

Coevolutionary Analysis Identifies Protein–Protein Interaction Sites between HIV-1 Reverse Transcriptase and Integrase
por: Hetti Arachchilage, Madara, et al.
Publicado: (2016)

Structural and Functional Aspects of Foamy Virus Protease-Reverse Transcriptase
por: Wöhrl, Birgitta M.
Publicado: (2019)

Structures of Substrate Complexes of Foamy Viral Protease-Reverse Transcriptase
por: Nowacka, Marzena, et al.
Publicado: (2021)

MiDRMpol: A High-Throughput Multiplexed Amplicon Sequencing Workflow to Quantify HIV-1 Drug Resistance Mutations against Protease, Reverse Transcriptase, and Integrase Inhibitors
por: Aralaguppe, Shambhu G., et al.
Publicado: (2019)

Real-time polymerase chain reaction optimised for hepatitis C virus detection in dried blood spots from HIV-exposed infants, KwaZulu-Natal, South Africa
por: Naidoo, Anneta, et al.
Publicado: (2016)

HIV-1 Protease and Reverse Transcriptase Control the Architecture of Their Nucleocapsid Partner
por: Mirambeau, Gilles, et al.
Publicado: (2007)

HIV-1 Protease and Reverse Transcriptase Control the Architecture of Their Nucleocapsid Partner
Publicado: (2014)

Hepatic tuberculosis in human immunodeficiency virus co-infected adults: a case series of South African adults
por: Gounder, Lilishia, et al.
Publicado: (2017)

Effect of lipemia and bilirubinemia on HIV-1 protease and reverse transcriptase genotyping and phenotyping success: a five-year analysis
por: Pattery, T, et al.
Publicado: (2010)

Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase
por: Costi, Roberta, et al.
Publicado: (2014)

Flavonol 7-O-Glucoside Herbacitrin Inhibits HIV-1 Replication through Simultaneous Integrase and Reverse Transcriptase Inhibition
por: Áy, Éva, et al.
Publicado: (2019)

HIV-1 Reverse Transcriptase/Integrase Dual Inhibitors: A Review of Recent Advances and Structure-activity Relationship Studies
por: Mahboubi-Rabbani, Mohammad, et al.
Publicado: (2021)

HIV-1 Subtype B Protease and Reverse Transcriptase Amino Acid Covariation
por: Rhee, Soo-Yon, et al.
Publicado: (2007)

Polymorphisms in reverse transcriptase and protease genes of HIV-1 subtype C from Mumbai
por: Dahake, Ritwik, et al.
Publicado: (2014)

Sequence and structure based models of HIV-1 protease and reverse transcriptase drug resistance
por: Masso, Majid, et al.
Publicado: (2013)

Binding interface and impact on protease cleavage for an RNA aptamer to HIV-1 reverse transcriptase
por: Nguyen, Phuong D M, et al.
Publicado: (2020)

Weight gain among treatment‐naïve persons with HIV starting integrase inhibitors compared to non‐nucleoside reverse transcriptase inhibitors or protease inhibitors in a large observational cohort in the United States and Canada
por: Bourgi, Kassem, et al.
Publicado: (2020)

Short Communication: Dolutegravir-Based Regimens Are Active in Integrase Strand Transfer Inhibitor–Naive Patients with Nucleoside Reverse Transcriptase Inhibitor Resistance
por: Demarest, James, et al.
Publicado: (2018)

In Vitro Anti-HIV-1 Reverse Transcriptase and Integrase Properties of Punica granatum L. Leaves, Bark, and Peel Extracts and Their Main Compounds
por: Sanna, Cinzia, et al.
Publicado: (2021)

Acquired HIV drug resistance and virologic monitoring in a HIV hyper-endemic setting in KwaZulu-Natal Province, South Africa
por: Chimukangara, Benjamin, et al.
Publicado: (2021)

Estimating the Fitness Cost of Escape from HLA Presentation in HIV-1 Protease and Reverse Transcriptase
por: Mostowy, Rafal, et al.
Publicado: (2012)

Integrase Inhibitor Resistance Mechanisms and Structural Characteristics in Antiretroviral Therapy-Experienced, Integrase Inhibitor-Naive Adults with HIV-1 Infection Treated with Dolutegravir plus Two Nucleoside Reverse Transcriptase Inhibitors in the DAWNING Study
por: Underwood, Mark, et al.
Publicado: (2022)

Recurrent tuberculosis among HIV-coinfected patients: a case series from KwaZulu-Natal
por: Naidoo, Kogieleum, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_lau30253fat6lkvv5ja5hasdl0