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Increased Functional Connectivity of the Precuneus in Individuals with a Family History of Alzheimer’s Disease

BACKGROUND: First-degree relatives of individuals with late-onset Alzheimer’s disease (AD) have increased risk for AD, with children of affected parents at an especially high risk. OBJECTIVE: We aimed to investigate default mode network connectivity, medial temporal cortex volume, and cognition in c...

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Autores principales: Green, Zachary D., Vidoni, Eric D., Swerdlow, Russell H., Burns, Jeffrey M., Morris, Jill K., Honea, Robyn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912732/
https://www.ncbi.nlm.nih.gov/pubmed/36463439
http://dx.doi.org/10.3233/JAD-210326
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author Green, Zachary D.
Vidoni, Eric D.
Swerdlow, Russell H.
Burns, Jeffrey M.
Morris, Jill K.
Honea, Robyn A.
author_facet Green, Zachary D.
Vidoni, Eric D.
Swerdlow, Russell H.
Burns, Jeffrey M.
Morris, Jill K.
Honea, Robyn A.
author_sort Green, Zachary D.
collection PubMed
description BACKGROUND: First-degree relatives of individuals with late-onset Alzheimer’s disease (AD) have increased risk for AD, with children of affected parents at an especially high risk. OBJECTIVE: We aimed to investigate default mode network connectivity, medial temporal cortex volume, and cognition in cognitively healthy (CH) individuals with (FH+) and without (FH-) a family history of AD, alongside amnestic mild cognitive impairment (aMCI) and AD individuals, to determine the context and directionality of dysfunction in at-risk individuals. Our primary hypothesis was that there would be a linear decline (CH FH- > CH FH+ > aMCI > AD) within the risk groups on all measures of AD risk. METHODS: We used MRI and fMRI to study cognitively healthy individuals (n = 28) with and without AD family history (FH+ and FH-, respectively), those with aMCI (n = 31) and early-stage AD (n = 25). We tested connectivity within the default mode network, as well as measures of volume and thickness within the medial temporal cortex and selected seed regions. RESULTS: As expected, we identified decreased medial temporal cortex volumes in the aMCI and AD groups compared to cognitively healthy groups. We also observed patterns of connectivity across risk groups that suggest a nonlinear relationship of change, such that the FH+ group showed increased connectivity compared to the FH- and AD groups (CH FH+ > CH FH- > aMCI > AD). This pattern emerged primarily in connectivity between the precuneus and frontal regions. CONCLUSION: These results add to a growing literature that suggests compensatory brain function in otherwise cognitively healthy individuals with a family history of AD.
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spelling pubmed-99127322023-02-11 Increased Functional Connectivity of the Precuneus in Individuals with a Family History of Alzheimer’s Disease Green, Zachary D. Vidoni, Eric D. Swerdlow, Russell H. Burns, Jeffrey M. Morris, Jill K. Honea, Robyn A. J Alzheimers Dis Research Article BACKGROUND: First-degree relatives of individuals with late-onset Alzheimer’s disease (AD) have increased risk for AD, with children of affected parents at an especially high risk. OBJECTIVE: We aimed to investigate default mode network connectivity, medial temporal cortex volume, and cognition in cognitively healthy (CH) individuals with (FH+) and without (FH-) a family history of AD, alongside amnestic mild cognitive impairment (aMCI) and AD individuals, to determine the context and directionality of dysfunction in at-risk individuals. Our primary hypothesis was that there would be a linear decline (CH FH- > CH FH+ > aMCI > AD) within the risk groups on all measures of AD risk. METHODS: We used MRI and fMRI to study cognitively healthy individuals (n = 28) with and without AD family history (FH+ and FH-, respectively), those with aMCI (n = 31) and early-stage AD (n = 25). We tested connectivity within the default mode network, as well as measures of volume and thickness within the medial temporal cortex and selected seed regions. RESULTS: As expected, we identified decreased medial temporal cortex volumes in the aMCI and AD groups compared to cognitively healthy groups. We also observed patterns of connectivity across risk groups that suggest a nonlinear relationship of change, such that the FH+ group showed increased connectivity compared to the FH- and AD groups (CH FH+ > CH FH- > aMCI > AD). This pattern emerged primarily in connectivity between the precuneus and frontal regions. CONCLUSION: These results add to a growing literature that suggests compensatory brain function in otherwise cognitively healthy individuals with a family history of AD. IOS Press 2023-01-17 /pmc/articles/PMC9912732/ /pubmed/36463439 http://dx.doi.org/10.3233/JAD-210326 Text en © 2023 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Green, Zachary D.
Vidoni, Eric D.
Swerdlow, Russell H.
Burns, Jeffrey M.
Morris, Jill K.
Honea, Robyn A.
Increased Functional Connectivity of the Precuneus in Individuals with a Family History of Alzheimer’s Disease
title Increased Functional Connectivity of the Precuneus in Individuals with a Family History of Alzheimer’s Disease
title_full Increased Functional Connectivity of the Precuneus in Individuals with a Family History of Alzheimer’s Disease
title_fullStr Increased Functional Connectivity of the Precuneus in Individuals with a Family History of Alzheimer’s Disease
title_full_unstemmed Increased Functional Connectivity of the Precuneus in Individuals with a Family History of Alzheimer’s Disease
title_short Increased Functional Connectivity of the Precuneus in Individuals with a Family History of Alzheimer’s Disease
title_sort increased functional connectivity of the precuneus in individuals with a family history of alzheimer’s disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912732/
https://www.ncbi.nlm.nih.gov/pubmed/36463439
http://dx.doi.org/10.3233/JAD-210326
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