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A versatile laboratory setup for high resolution X-ray phase contrast tomography and scintillator characterization
BACKGROUND: X-ray micro-tomography (μCT) is a powerful non-destructive 3D imaging method applied in many scientific fields. In combination with propagation-based phase-contrast, the method is suitable for samples with low absorption contrast. Phase contrast tomography has become available in the lab...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912733/ https://www.ncbi.nlm.nih.gov/pubmed/36404526 http://dx.doi.org/10.3233/XST-221294 |
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author | Dierks, Hanna Stjärneblad, Philip Wallentin, Jesper |
author_facet | Dierks, Hanna Stjärneblad, Philip Wallentin, Jesper |
author_sort | Dierks, Hanna |
collection | PubMed |
description | BACKGROUND: X-ray micro-tomography (μCT) is a powerful non-destructive 3D imaging method applied in many scientific fields. In combination with propagation-based phase-contrast, the method is suitable for samples with low absorption contrast. Phase contrast tomography has become available in the lab with the ongoing development of micro-focused tube sources, but it requires sensitive and high-resolution X-ray detectors. The development of novel scintillation detectors, particularly for microscopy, requires more flexibility than available in commercial tomography systems. OBJECTIVE: We aim to develop a compact, flexible, and versatile μCT laboratory setup that combines absorption and phase contrast imaging as well as the option to use it for scintillator characterization. Here, we present details on the design and implementation of the setup. METHODS: We used the setup for μCT in absorption and propagation-based phase-contrast mode, as well as to study a perovskite scintillator. RESULTS: We show the 2D and 3D performance in absorption and phase contrast mode, as well as how the setup can be used for testing new scintillator materials in a realistic imaging environment. A spatial resolution of around 1.3μm is measured in 2D and 3D. CONCLUSIONS: The setup meets the needs for common absorption μCT applications and offers increased contrast in phase contrast mode. The availability of a versatile laboratory μCT setup allows not only for easy access to tomographic measurements, but also enables a prompt monitoring and feedback beneficial for advances in scintillator fabrication. |
format | Online Article Text |
id | pubmed-9912733 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-99127332023-02-11 A versatile laboratory setup for high resolution X-ray phase contrast tomography and scintillator characterization Dierks, Hanna Stjärneblad, Philip Wallentin, Jesper J Xray Sci Technol Research Article BACKGROUND: X-ray micro-tomography (μCT) is a powerful non-destructive 3D imaging method applied in many scientific fields. In combination with propagation-based phase-contrast, the method is suitable for samples with low absorption contrast. Phase contrast tomography has become available in the lab with the ongoing development of micro-focused tube sources, but it requires sensitive and high-resolution X-ray detectors. The development of novel scintillation detectors, particularly for microscopy, requires more flexibility than available in commercial tomography systems. OBJECTIVE: We aim to develop a compact, flexible, and versatile μCT laboratory setup that combines absorption and phase contrast imaging as well as the option to use it for scintillator characterization. Here, we present details on the design and implementation of the setup. METHODS: We used the setup for μCT in absorption and propagation-based phase-contrast mode, as well as to study a perovskite scintillator. RESULTS: We show the 2D and 3D performance in absorption and phase contrast mode, as well as how the setup can be used for testing new scintillator materials in a realistic imaging environment. A spatial resolution of around 1.3μm is measured in 2D and 3D. CONCLUSIONS: The setup meets the needs for common absorption μCT applications and offers increased contrast in phase contrast mode. The availability of a versatile laboratory μCT setup allows not only for easy access to tomographic measurements, but also enables a prompt monitoring and feedback beneficial for advances in scintillator fabrication. IOS Press 2023-01-27 /pmc/articles/PMC9912733/ /pubmed/36404526 http://dx.doi.org/10.3233/XST-221294 Text en © 2023 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Dierks, Hanna Stjärneblad, Philip Wallentin, Jesper A versatile laboratory setup for high resolution X-ray phase contrast tomography and scintillator characterization |
title | A versatile laboratory setup for high resolution X-ray phase contrast tomography and scintillator characterization |
title_full | A versatile laboratory setup for high resolution X-ray phase contrast tomography and scintillator characterization |
title_fullStr | A versatile laboratory setup for high resolution X-ray phase contrast tomography and scintillator characterization |
title_full_unstemmed | A versatile laboratory setup for high resolution X-ray phase contrast tomography and scintillator characterization |
title_short | A versatile laboratory setup for high resolution X-ray phase contrast tomography and scintillator characterization |
title_sort | versatile laboratory setup for high resolution x-ray phase contrast tomography and scintillator characterization |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912733/ https://www.ncbi.nlm.nih.gov/pubmed/36404526 http://dx.doi.org/10.3233/XST-221294 |
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