A Small Molecule Selected from a DNA‐Encoded Library of Natural Products That Binds to TNF‐α and Attenuates Inflammation In Vivo (Adv. Sci. 21/2022)

nDEL in Reversable Pharmacology Natural product DNA‐encoded library (nDEL) has great value in reverse pharmacology. In article number 2201258, Peixiang Ma, Hongtao Xu, Guang Yang, and co‐workers applied nDEL in a reverse pharmacology study targeting tumor necrosis factor α (TNF‐α). Several natural p...

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Detalles Bibliográficos
Autores principales: Wang, Shuyue, Shi, Xiaojie, Li, Jie, Huang, Qianping, Ji, Qun, Yao, Ying, Wang, Tao, Liu, Lili, Ye, Min, Deng, Yun, Ma, Peixiang, Xu, Hongtao, Yang, Guang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Frontispiece
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912745/
http://dx.doi.org/10.1002/advs.202270130
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author Wang, Shuyue
Shi, Xiaojie
Li, Jie
Huang, Qianping
Ji, Qun
Yao, Ying
Wang, Tao
Liu, Lili
Ye, Min
Deng, Yun
Ma, Peixiang
Xu, Hongtao
Yang, Guang
author_facet Wang, Shuyue
Shi, Xiaojie
Li, Jie
Huang, Qianping
Ji, Qun
Yao, Ying
Wang, Tao
Liu, Lili
Ye, Min
Deng, Yun
Ma, Peixiang
Xu, Hongtao
Yang, Guang
author_sort Wang, Shuyue
collection PubMed
description nDEL in Reversable Pharmacology Natural product DNA‐encoded library (nDEL) has great value in reverse pharmacology. In article number 2201258, Peixiang Ma, Hongtao Xu, Guang Yang, and co‐workers applied nDEL in a reverse pharmacology study targeting tumor necrosis factor α (TNF‐α). Several natural products, particularly kaempferol are identified to recognize and attenuate the TNF‐α signaling as that of adalimumab, and reduce mice ear inflammation. [Image: see text]
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spelling pubmed-99127452023-02-13 A Small Molecule Selected from a DNA‐Encoded Library of Natural Products That Binds to TNF‐α and Attenuates Inflammation In Vivo (Adv. Sci. 21/2022) Wang, Shuyue Shi, Xiaojie Li, Jie Huang, Qianping Ji, Qun Yao, Ying Wang, Tao Liu, Lili Ye, Min Deng, Yun Ma, Peixiang Xu, Hongtao Yang, Guang Adv Sci (Weinh) Frontispiece nDEL in Reversable Pharmacology Natural product DNA‐encoded library (nDEL) has great value in reverse pharmacology. In article number 2201258, Peixiang Ma, Hongtao Xu, Guang Yang, and co‐workers applied nDEL in a reverse pharmacology study targeting tumor necrosis factor α (TNF‐α). Several natural products, particularly kaempferol are identified to recognize and attenuate the TNF‐α signaling as that of adalimumab, and reduce mice ear inflammation. [Image: see text] John Wiley and Sons Inc. 2022-07-25 /pmc/articles/PMC9912745/ http://dx.doi.org/10.1002/advs.202270130 Text en © 2022 Wiley‐VCH GmbH https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Frontispiece
Wang, Shuyue
Shi, Xiaojie
Li, Jie
Huang, Qianping
Ji, Qun
Yao, Ying
Wang, Tao
Liu, Lili
Ye, Min
Deng, Yun
Ma, Peixiang
Xu, Hongtao
Yang, Guang
A Small Molecule Selected from a DNA‐Encoded Library of Natural Products That Binds to TNF‐α and Attenuates Inflammation In Vivo (Adv. Sci. 21/2022)
title A Small Molecule Selected from a DNA‐Encoded Library of Natural Products That Binds to TNF‐α and Attenuates Inflammation In Vivo (Adv. Sci. 21/2022)
title_full A Small Molecule Selected from a DNA‐Encoded Library of Natural Products That Binds to TNF‐α and Attenuates Inflammation In Vivo (Adv. Sci. 21/2022)
title_fullStr A Small Molecule Selected from a DNA‐Encoded Library of Natural Products That Binds to TNF‐α and Attenuates Inflammation In Vivo (Adv. Sci. 21/2022)
title_full_unstemmed A Small Molecule Selected from a DNA‐Encoded Library of Natural Products That Binds to TNF‐α and Attenuates Inflammation In Vivo (Adv. Sci. 21/2022)
title_short A Small Molecule Selected from a DNA‐Encoded Library of Natural Products That Binds to TNF‐α and Attenuates Inflammation In Vivo (Adv. Sci. 21/2022)
title_sort small molecule selected from a dna‐encoded library of natural products that binds to tnf‐α and attenuates inflammation in vivo (adv. sci. 21/2022)
topic Frontispiece
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912745/
http://dx.doi.org/10.1002/advs.202270130
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