Cargando…

Dual functions of the SARS-CoV-2 nucleocapsid domains mediate RNA binding and phase separation

Detalles Bibliográficos
Autores principales:	Estelle, Aidan B., Yu, Zhen, Allen, Patrick, Barbar, Elisar J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Biophysical Society. Published by Elsevier Inc. 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912761/ http://dx.doi.org/10.1016/j.bpj.2022.11.1286

Ejemplares similares

RNA structure and multiple weak interactions balance the interplay between RNA binding and phase separation of SARS-CoV-2 nucleocapsid
por: Estelle, Aidan B, et al.
Publicado: (2023)

Multivalent binding of the partially disordered SARS-CoV-2 nucleocapsid phosphoprotein dimer to RNA
por: Forsythe, Heather M., et al.
Publicado: (2021)

Abstract 2610: Modifications in SARS-CoV-2 N Linker Region Regulate RNA Interactions and Phase Separation
por: Shah, Sahana, et al.
Publicado: (2023)

Quantifying cooperative multisite binding in the hub protein LC8 through Bayesian inference
por: Estelle, Aidan B., et al.
Publicado: (2023)

NMR Characterization of Self-Association Domains Promoted by Interactions with LC8 Hub Protein
por: Barbar, Elisar, et al.
Publicado: (2014)

Specific viral RNA drives the SARS CoV-2 nucleocapsid to phase separate
por: Iserman, Christiane, et al.
Publicado: (2020)

Liquid–liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA
por: Chen, Hui, et al.
Publicado: (2020)

Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid
por: Iserman, Christiane, et al.
Publicado: (2020)

The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA
por: Cubuk, Jasmine, et al.
Publicado: (2021)

Phase separation by the SARS-CoV-2 nucleocapsid protein: Consensus and open questions
por: Cascarina, Sean M., et al.
Publicado: (2022)

Phase separation underlies interactions of the SARS-CoV-2 nucleocapsid protein with nucleoli
por: Dogra, Priyanka, et al.
Publicado: (2023)

SARS‐CoV‐2 nucleocapsid protein phase‐separates with RNA and with human hnRNPs
por: Perdikari, Theodora Myrto, et al.
Publicado: (2020)

Nucleocapsid protein of SARS-CoV-2 phase separates into RNA-rich polymerase-containing condensates
por: Savastano, Adriana, et al.
Publicado: (2020)

A review of the effects of ATP and hydroxychloroquine on the phase separation of the SARS-CoV-2 nucleocapsid protein
por: Dang, Mei, et al.
Publicado: (2022)

A novel phosphorylation site in SARS-CoV-2 nucleocapsid regulates its RNA-binding capacity and phase separation in host cells
por: Wu, Junyu, et al.
Publicado: (2022)

Modular characterization of SARS-CoV-2 nucleocapsid protein domain functions in nucleocapsid-like assembly
por: Wang, Yan, et al.
Publicado: (2023)

Liquid-liquid phase separation of nucleocapsid proteins during SARS-CoV-2 and HIV-1 replication
por: Chau, Bao-An, et al.
Publicado: (2023)

Domain-specific biochemical and serological characterization of SARS-CoV-2 nucleocapsid protein
por: Wu, Chao, et al.
Publicado: (2021)

SARS‐CoV‐2 nucleocapsid protein interacts with immunoregulators and stress granules and phase separates to form liquid droplets
por: Somasekharan, Syam Prakash, et al.
Publicado: (2021)

Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures
por: Roden, Christine A, et al.
Publicado: (2022)

SARS-CoV-2 nucleocapsid protein undergoes liquid-liquid phase separation stimulated by RNA and partitions into phases of human ribonucleoproteins.
por: Perdikari, Theodora Myrto, et al.
Publicado: (2020)

ATP biphasically modulates LLPS of SARS-CoV-2 nucleocapsid protein and specifically binds its RNA-binding domain
por: Dang, Mei, et al.
Publicado: (2021)

Thermostability of the N-Terminal RNA-Binding Domain of the SARS-CoV Nucleocapsid Protein: Experiments and Numerical Simulations
por: Fang, Huey-Jen, et al.
Publicado: (2009)

Detection of breastmilk antibodies targeting SARS-CoV-2 nucleocapsid, spike and receptor-binding-domain antigens
por: Favara, D. M., et al.
Publicado: (2020)

Characterizing nucleic acid interactions with the N-Terminal binding domain of the SARS-CoV-2 nucleocapsid protein
por: Cubuk, Jasmine, et al.
Publicado: (2022)

RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation
por: Wu, Yaoxing, et al.
Publicado: (2021)

Pan-retroviral Nucleocapsid-Mediated Phase Separation Regulates Genomic RNA Positioning and Trafficking
por: Monette, Anne, et al.
Publicado: (2020)

Nucleocapsid protein binding DNA aptamers for detection of SARS-COV-2
por: Neff, Charles P., et al.
Publicado: (2023)

Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2
por: Zhao, Dan, et al.
Publicado: (2021)

Molecular determinants for regulation of G3BP1/2 phase separation by the SARS-CoV-2 nucleocapsid protein
por: Huang, Wenjie, et al.
Publicado: (2021)

SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2b
por: Aloise, Chiara, et al.
Publicado: (2023)

SARS-CoV-2 nucleocapsid and Nsp3 binding: an in silico study
por: Khan, Muhammad Tahir, et al.
Publicado: (2020)

SARS-CoV-2 nucleocapsid protein phase separates with G3BPs to disassemble stress granules and facilitate viral production
por: Luo, Lingling, et al.
Publicado: (2021)

Structural characterization of the C-terminal domain of SARS-CoV-2 nucleocapsid protein
por: Zhou, Renjie, et al.
Publicado: (2020)

Heterogeneous antibodies against SARS-CoV-2 spike receptor binding domain and nucleocapsid with implications for COVID-19 immunity
por: McAndrews, Kathleen M., et al.
Publicado: (2020)

Structural insights into the mechanism of RNA recognition by the N-terminal RNA-binding domain of the SARS-CoV-2 nucleocapsid phosphoprotein
por: Khan, Abbas, et al.
Publicado: (2020)

Attenuated Subcomponent Vaccine Design Targeting the SARS-CoV-2 Nucleocapsid Phosphoprotein RNA Binding Domain: In Silico Analysis
por: Chukwudozie, Onyeka S., et al.
Publicado: (2020)

Indian Ethnomedicinal Phytochemicals as Promising Inhibitors of RNA-Binding Domain of SARS-CoV-2 Nucleocapsid Phosphoprotein: An In Silico Study
por: Muthumanickam, Sankar, et al.
Publicado: (2021)

Characterization of SARS-CoV-2 nucleocapsid protein reveals multiple functional consequences of the C-terminal domain
por: Wu, Chao, et al.
Publicado: (2021)

Protein Interactions Within the Cytoplasmic Dynein Complex as Probed by Mass Spectrometry and Nmr
por: Barbar, Elisar, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_j1dp15ihlpqf2gtgu1bpof5i1h