Cargando…

The conformational space of the SARS-CoV-2 main protease active site loops is determined by ligand binding and interprotomer allostery

Detalles Bibliográficos
Autores principales: Lee, Ethan, Rauscher, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Biophysical Society. Published by Elsevier Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912765/
http://dx.doi.org/10.1016/j.bpj.2022.11.479
_version_ 1784885274288848896
author Lee, Ethan
Rauscher, Sarah
author_facet Lee, Ethan
Rauscher, Sarah
author_sort Lee, Ethan
collection PubMed
description
format Online
Article
Text
id pubmed-9912765
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Biophysical Society. Published by Elsevier Inc.
record_format MEDLINE/PubMed
spelling pubmed-99127652023-02-10 The conformational space of the SARS-CoV-2 main protease active site loops is determined by ligand binding and interprotomer allostery Lee, Ethan Rauscher, Sarah Biophys J Article Biophysical Society. Published by Elsevier Inc. 2023-02-10 2023-02-10 /pmc/articles/PMC9912765/ http://dx.doi.org/10.1016/j.bpj.2022.11.479 Text en Copyright © 2022 Biophysical Society. Published by Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Lee, Ethan
Rauscher, Sarah
The conformational space of the SARS-CoV-2 main protease active site loops is determined by ligand binding and interprotomer allostery
title The conformational space of the SARS-CoV-2 main protease active site loops is determined by ligand binding and interprotomer allostery
title_full The conformational space of the SARS-CoV-2 main protease active site loops is determined by ligand binding and interprotomer allostery
title_fullStr The conformational space of the SARS-CoV-2 main protease active site loops is determined by ligand binding and interprotomer allostery
title_full_unstemmed The conformational space of the SARS-CoV-2 main protease active site loops is determined by ligand binding and interprotomer allostery
title_short The conformational space of the SARS-CoV-2 main protease active site loops is determined by ligand binding and interprotomer allostery
title_sort conformational space of the sars-cov-2 main protease active site loops is determined by ligand binding and interprotomer allostery
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912765/
http://dx.doi.org/10.1016/j.bpj.2022.11.479
work_keys_str_mv AT leeethan theconformationalspaceofthesarscov2mainproteaseactivesiteloopsisdeterminedbyligandbindingandinterprotomerallostery
AT rauschersarah theconformationalspaceofthesarscov2mainproteaseactivesiteloopsisdeterminedbyligandbindingandinterprotomerallostery
AT leeethan conformationalspaceofthesarscov2mainproteaseactivesiteloopsisdeterminedbyligandbindingandinterprotomerallostery
AT rauschersarah conformationalspaceofthesarscov2mainproteaseactivesiteloopsisdeterminedbyligandbindingandinterprotomerallostery