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A Case of Minimally Progressive Prodromal Alzheimer’s Disease

Prodromal Alzheimer’s disease (AD) is a neurodegenerative condition typically progressing to dementia within 3 years. We describe a case of a mild cognitive impairment (MCI) patient with biomarker evidence for amyloidosis, tau, and neurodegeneration who had minimal changes in clinical phenotype duri...

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Detalles Bibliográficos
Autores principales: Rosenbloom, Michael H., Barclay, Terry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912823/
https://www.ncbi.nlm.nih.gov/pubmed/36777327
http://dx.doi.org/10.3233/ADR-220065
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author Rosenbloom, Michael H.
Barclay, Terry
author_facet Rosenbloom, Michael H.
Barclay, Terry
author_sort Rosenbloom, Michael H.
collection PubMed
description Prodromal Alzheimer’s disease (AD) is a neurodegenerative condition typically progressing to dementia within 3 years. We describe a case of a mild cognitive impairment (MCI) patient with biomarker evidence for amyloidosis, tau, and neurodegeneration who had minimal changes in clinical phenotype during an 11-year period. AD biomarkers were obtained with cerebrospinal fluid analysis and amyloid PET imaging, both of which supported a biological diagnosis of AD. However, the patient’s neuropsychological profile remained stable over 11 years except for mild memory-retrieval changes. This case provides evidence that MCI with supportive AD biomarkers may have an atypically minimal progression.
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spelling pubmed-99128232023-02-11 A Case of Minimally Progressive Prodromal Alzheimer’s Disease Rosenbloom, Michael H. Barclay, Terry J Alzheimers Dis Rep Short Communication Prodromal Alzheimer’s disease (AD) is a neurodegenerative condition typically progressing to dementia within 3 years. We describe a case of a mild cognitive impairment (MCI) patient with biomarker evidence for amyloidosis, tau, and neurodegeneration who had minimal changes in clinical phenotype during an 11-year period. AD biomarkers were obtained with cerebrospinal fluid analysis and amyloid PET imaging, both of which supported a biological diagnosis of AD. However, the patient’s neuropsychological profile remained stable over 11 years except for mild memory-retrieval changes. This case provides evidence that MCI with supportive AD biomarkers may have an atypically minimal progression. IOS Press 2023-01-19 /pmc/articles/PMC9912823/ /pubmed/36777327 http://dx.doi.org/10.3233/ADR-220065 Text en © 2023 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Rosenbloom, Michael H.
Barclay, Terry
A Case of Minimally Progressive Prodromal Alzheimer’s Disease
title A Case of Minimally Progressive Prodromal Alzheimer’s Disease
title_full A Case of Minimally Progressive Prodromal Alzheimer’s Disease
title_fullStr A Case of Minimally Progressive Prodromal Alzheimer’s Disease
title_full_unstemmed A Case of Minimally Progressive Prodromal Alzheimer’s Disease
title_short A Case of Minimally Progressive Prodromal Alzheimer’s Disease
title_sort case of minimally progressive prodromal alzheimer’s disease
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912823/
https://www.ncbi.nlm.nih.gov/pubmed/36777327
http://dx.doi.org/10.3233/ADR-220065
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