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A Case of Minimally Progressive Prodromal Alzheimer’s Disease
Prodromal Alzheimer’s disease (AD) is a neurodegenerative condition typically progressing to dementia within 3 years. We describe a case of a mild cognitive impairment (MCI) patient with biomarker evidence for amyloidosis, tau, and neurodegeneration who had minimal changes in clinical phenotype duri...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912823/ https://www.ncbi.nlm.nih.gov/pubmed/36777327 http://dx.doi.org/10.3233/ADR-220065 |
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author | Rosenbloom, Michael H. Barclay, Terry |
author_facet | Rosenbloom, Michael H. Barclay, Terry |
author_sort | Rosenbloom, Michael H. |
collection | PubMed |
description | Prodromal Alzheimer’s disease (AD) is a neurodegenerative condition typically progressing to dementia within 3 years. We describe a case of a mild cognitive impairment (MCI) patient with biomarker evidence for amyloidosis, tau, and neurodegeneration who had minimal changes in clinical phenotype during an 11-year period. AD biomarkers were obtained with cerebrospinal fluid analysis and amyloid PET imaging, both of which supported a biological diagnosis of AD. However, the patient’s neuropsychological profile remained stable over 11 years except for mild memory-retrieval changes. This case provides evidence that MCI with supportive AD biomarkers may have an atypically minimal progression. |
format | Online Article Text |
id | pubmed-9912823 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-99128232023-02-11 A Case of Minimally Progressive Prodromal Alzheimer’s Disease Rosenbloom, Michael H. Barclay, Terry J Alzheimers Dis Rep Short Communication Prodromal Alzheimer’s disease (AD) is a neurodegenerative condition typically progressing to dementia within 3 years. We describe a case of a mild cognitive impairment (MCI) patient with biomarker evidence for amyloidosis, tau, and neurodegeneration who had minimal changes in clinical phenotype during an 11-year period. AD biomarkers were obtained with cerebrospinal fluid analysis and amyloid PET imaging, both of which supported a biological diagnosis of AD. However, the patient’s neuropsychological profile remained stable over 11 years except for mild memory-retrieval changes. This case provides evidence that MCI with supportive AD biomarkers may have an atypically minimal progression. IOS Press 2023-01-19 /pmc/articles/PMC9912823/ /pubmed/36777327 http://dx.doi.org/10.3233/ADR-220065 Text en © 2023 – The authors. Published by IOS Press https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Rosenbloom, Michael H. Barclay, Terry A Case of Minimally Progressive Prodromal Alzheimer’s Disease |
title | A Case of Minimally Progressive Prodromal Alzheimer’s Disease |
title_full | A Case of Minimally Progressive Prodromal Alzheimer’s Disease |
title_fullStr | A Case of Minimally Progressive Prodromal Alzheimer’s Disease |
title_full_unstemmed | A Case of Minimally Progressive Prodromal Alzheimer’s Disease |
title_short | A Case of Minimally Progressive Prodromal Alzheimer’s Disease |
title_sort | case of minimally progressive prodromal alzheimer’s disease |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912823/ https://www.ncbi.nlm.nih.gov/pubmed/36777327 http://dx.doi.org/10.3233/ADR-220065 |
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