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Physiology-Enhanced Data Analytics to Evaluate the Effect of Altitude on Intraocular Pressure and Ocular Hemodynamics

Altitude affects intraocular pressure (IOP); however, the underlying mechanisms involved and its relationship with ocular hemodynamics remain unknown. Herein, a validated mathematical modeling approach was used for a physiology-enhanced (pe-) analysis of the Mont Blanc study (MBS), estimating the ef...

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Autores principales: Vercellin, Alice Verticchio, Harris, Alon, Belamkar, Aditya, Zukerman, Ryan, Carichino, Lucia, Szopos, Marcela, Siesky, Brent, Quaranta, Luciano, Bruttini, Carlo, Oddone, Francesco, Riva, Ivano, Guidoboni, Giovanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912910/
https://www.ncbi.nlm.nih.gov/pubmed/36777090
http://dx.doi.org/10.3390/photonics9030158
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author Vercellin, Alice Verticchio
Harris, Alon
Belamkar, Aditya
Zukerman, Ryan
Carichino, Lucia
Szopos, Marcela
Siesky, Brent
Quaranta, Luciano
Bruttini, Carlo
Oddone, Francesco
Riva, Ivano
Guidoboni, Giovanna
author_facet Vercellin, Alice Verticchio
Harris, Alon
Belamkar, Aditya
Zukerman, Ryan
Carichino, Lucia
Szopos, Marcela
Siesky, Brent
Quaranta, Luciano
Bruttini, Carlo
Oddone, Francesco
Riva, Ivano
Guidoboni, Giovanna
author_sort Vercellin, Alice Verticchio
collection PubMed
description Altitude affects intraocular pressure (IOP); however, the underlying mechanisms involved and its relationship with ocular hemodynamics remain unknown. Herein, a validated mathematical modeling approach was used for a physiology-enhanced (pe-) analysis of the Mont Blanc study (MBS), estimating the effects of altitude on IOP, blood pressure (BP), and retinal hemodynamics. In the MBS, IOP and BP were measured in 33 healthy volunteers at 77 and 3466 m above sea level. Pe-retinal hemodynamics analysis predicted a statistically significant increase (p < 0.001) in the model predicted blood flow and pressure within the retinal vasculature following increases in systemic BP with altitude measured in the MBS. Decreased IOP with altitude led to a non-monotonic behavior of the model predicted retinal vascular resistances, with significant decreases in the resistance of the central retinal artery (p < 0.001) and retinal venules (p = 0.003) and a non-significant increase in the resistance in the central retinal vein (p = 0.253). Pe-aqueous humor analysis showed that a decrease in osmotic pressure difference (OPD) may underlie the difference in IOP measured at different altitudes in the MBS. Our analysis suggests that venules bear the significant portion of the IOP pressure load within the ocular vasculature, and that OPD plays an important role in regulating IOP with changes in altitude.
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spelling pubmed-99129102023-02-10 Physiology-Enhanced Data Analytics to Evaluate the Effect of Altitude on Intraocular Pressure and Ocular Hemodynamics Vercellin, Alice Verticchio Harris, Alon Belamkar, Aditya Zukerman, Ryan Carichino, Lucia Szopos, Marcela Siesky, Brent Quaranta, Luciano Bruttini, Carlo Oddone, Francesco Riva, Ivano Guidoboni, Giovanna Photonics Article Altitude affects intraocular pressure (IOP); however, the underlying mechanisms involved and its relationship with ocular hemodynamics remain unknown. Herein, a validated mathematical modeling approach was used for a physiology-enhanced (pe-) analysis of the Mont Blanc study (MBS), estimating the effects of altitude on IOP, blood pressure (BP), and retinal hemodynamics. In the MBS, IOP and BP were measured in 33 healthy volunteers at 77 and 3466 m above sea level. Pe-retinal hemodynamics analysis predicted a statistically significant increase (p < 0.001) in the model predicted blood flow and pressure within the retinal vasculature following increases in systemic BP with altitude measured in the MBS. Decreased IOP with altitude led to a non-monotonic behavior of the model predicted retinal vascular resistances, with significant decreases in the resistance of the central retinal artery (p < 0.001) and retinal venules (p = 0.003) and a non-significant increase in the resistance in the central retinal vein (p = 0.253). Pe-aqueous humor analysis showed that a decrease in osmotic pressure difference (OPD) may underlie the difference in IOP measured at different altitudes in the MBS. Our analysis suggests that venules bear the significant portion of the IOP pressure load within the ocular vasculature, and that OPD plays an important role in regulating IOP with changes in altitude. 2022-03 2022-03-05 /pmc/articles/PMC9912910/ /pubmed/36777090 http://dx.doi.org/10.3390/photonics9030158 Text en https://creativecommons.org/licenses/by/4.0/This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vercellin, Alice Verticchio
Harris, Alon
Belamkar, Aditya
Zukerman, Ryan
Carichino, Lucia
Szopos, Marcela
Siesky, Brent
Quaranta, Luciano
Bruttini, Carlo
Oddone, Francesco
Riva, Ivano
Guidoboni, Giovanna
Physiology-Enhanced Data Analytics to Evaluate the Effect of Altitude on Intraocular Pressure and Ocular Hemodynamics
title Physiology-Enhanced Data Analytics to Evaluate the Effect of Altitude on Intraocular Pressure and Ocular Hemodynamics
title_full Physiology-Enhanced Data Analytics to Evaluate the Effect of Altitude on Intraocular Pressure and Ocular Hemodynamics
title_fullStr Physiology-Enhanced Data Analytics to Evaluate the Effect of Altitude on Intraocular Pressure and Ocular Hemodynamics
title_full_unstemmed Physiology-Enhanced Data Analytics to Evaluate the Effect of Altitude on Intraocular Pressure and Ocular Hemodynamics
title_short Physiology-Enhanced Data Analytics to Evaluate the Effect of Altitude on Intraocular Pressure and Ocular Hemodynamics
title_sort physiology-enhanced data analytics to evaluate the effect of altitude on intraocular pressure and ocular hemodynamics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912910/
https://www.ncbi.nlm.nih.gov/pubmed/36777090
http://dx.doi.org/10.3390/photonics9030158
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