Cargando…

Drug discovery targeting SARS-CoV-2 membrane fusion

Detalles Bibliográficos
Autores principales:	Yang, Kailu, Wang, Chuchu, Kreutzberger, Alex J.B., Ojha, Ravi, Kuivanen, Suvi, Couoh-Cardel, Sergio, Muratcioglu, Serena, Eisen, Timothy J., White, K. Ian, Pfuetzner, Richard, Kuriyan, John, Vapalahti, Olli, Balistreri, Giuseppe, Kirchhausen, Tomas, Brunger, Axel T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Biophysical Society. Published by Elsevier Inc. 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912913/ http://dx.doi.org/10.1016/j.bpj.2022.11.1802

Ejemplares similares

Nanomolar inhibition of SARS-CoV-2 infection by an unmodified peptide targeting the prehairpin intermediate of the spike protein
por: Yang, Kailu, et al.
Publicado: (2022)

Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor
por: Yang, Kailu, et al.
Publicado: (2023)

Synergistic block of SARS-CoV-2 infection by combined drug inhibition of the host entry factors PIKfyve kinase and TMPRSS2 protease
por: Kreutzberger, Alex J.B., et al.
Publicado: (2021)

Synergistic Block of SARS-CoV-2 Infection by Combined Drug Inhibition of the Host Entry Factors PIKfyve Kinase and TMPRSS2 Protease
por: Kreutzberger, Alex J. B., et al.
Publicado: (2021)

Complete Protection from SARS-CoV-2 Lung Infection in Mice Through Combined Intranasal Delivery of PIKfyve Kinase and TMPRSS2 Protease Inhibitors
por: Kant, Ravi, et al.
Publicado: (2023)

Structural conservation among variants of the SARS-CoV-2 spike postfusion bundle
por: Yang, Kailu, et al.
Publicado: (2022)

Identification of linear human B-cell epitopes of tick-borne encephalitis virus
por: Kuivanen, Suvi, et al.
Publicado: (2014)

Complexin inhibits spontaneous release and synchronizes Ca(2+)-triggered synaptic vesicle fusion by distinct mechanisms
por: Lai, Ying, et al.
Publicado: (2014)

Computationally prioritized drugs inhibit SARS-CoV-2 infection and syncytia formation
por: Serra, Angela, et al.
Publicado: (2021)

Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro
por: Fred, Senem Merve, et al.
Publicado: (2022)

SARS-CoV-2 requires acidic pH to infect cells
por: Kreutzberger, Alex J. B., et al.
Publicado: (2022)

Phosphorylation of residues inside the SNARE complex suppresses secretory vesicle fusion
por: Malmersjö, Seth, et al.
Publicado: (2016)

Yeast V-ATPase Proteolipid Ring Acts as a Large-conductance Transmembrane Protein Pore
por: Couoh-Cardel, Sergio, et al.
Publicado: (2016)

Structural principles of SNARE complex recognition by the AAA+ protein NSF
por: White, K Ian, et al.
Publicado: (2018)

Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation
por: Bhattacharyya, Moitrayee, et al.
Publicado: (2020)

The Core Complex of the Ca(2+)-Triggered Presynaptic Fusion Machinery
por: Brunger, Axel T., et al.
Publicado: (2023)

SARS-CoV-2 Infection of Human Neurons Is TMPRSS2 Independent, Requires Endosomal Cell Entry, and Can Be Blocked by Inhibitors of Host Phosphoinositol-5 Kinase
por: Kettunen, Pinja, et al.
Publicado: (2023)

Fatal Tick-Borne Encephalitis Virus Infections Caused by Siberian and European Subtypes, Finland, 2015
por: Kuivanen, Suvi, et al.
Publicado: (2018)

Asian and African lineage Zika viruses show differential replication and innate immune responses in human dendritic cells and macrophages
por: Österlund, Pamela, et al.
Publicado: (2019)

Detection of novel tick-borne pathogen, Alongshan virus, in Ixodes ricinus ticks, south-eastern Finland, 2019
por: Kuivanen, Suvi, et al.
Publicado: (2019)

Munc18a Does Not Alter Fusion Rates Mediated by Neuronal SNAREs, Synaptotagmin, and Complexin
por: Zhang, Yunxiang, et al.
Publicado: (2015)

Novel NGS pipeline for virus discovery from a wide spectrum of hosts and sample types
por: Plyusnin, Ilya, et al.
Publicado: (2020)

NSF-mediated disassembly of on- and off-pathway SNARE complexes and inhibition by complexin
por: Choi, Ucheor B, et al.
Publicado: (2018)

Inhibition of calcium-triggered secretion by hydrocarbon-stapled peptides
por: Lai, Ying, et al.
Publicado: (2022)

Complexin-1 Enhances the On-Rate of Vesicle Docking via Simultaneous SNARE and Membrane Interactions
por: Diao, Jiajie, et al.
Publicado: (2013)

Discovery of a drug to treat airway mucus hypersecretion
por: Dickey, Burton F., et al.
Publicado: (2022)

Towards reconstitution of membrane fusion mediated by SNAREs and other synaptic proteins
por: Brunger, Axel T., et al.
Publicado: (2015)

Characterization of low-density granulocytes in COVID-19
por: Cabrera, Luz E., et al.
Publicado: (2021)

Structures of neurexophilin–neurexin complexes reveal a regulatory mechanism of alternative splicing
por: Wilson, Steven C, et al.
Publicado: (2019)

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity
por: Cantuti-Castelvetri, Ludovico, et al.
Publicado: (2020)

Unraveling the mechanisms of calcium-dependent secretion
por: Anantharam, Arun, et al.
Publicado: (2019)

Oxidative stress protein Oxr1 promotes V‐ATPase holoenzyme disassembly in catalytic activity‐independent manner
por: Khan, Md. Murad, et al.
Publicado: (2021)

Analysis of tripartite Synaptotagmin‐1‐SNARE‐complexin‐1 complexes in solution
por: Jaczynska, Klaudia, et al.
Publicado: (2022)

Novel flaviviruses from mosquitoes: Mosquito-specific evolutionary lineages within the phylogenetic group of mosquito-borne flaviviruses
por: Huhtamo, Eili, et al.
Publicado: (2014)

The pre-synaptic fusion machinery
por: Brunger, Axel T, et al.
Publicado: (2019)

The signaling lipid PI(3,5)P(2) stabilizes V(1)–V(o) sector interactions and activates the V-ATPase
por: Li, Sheena Claire, et al.
Publicado: (2014)

Survey of selected tick-borne diseases in dogs in Finland
por: Pérez Vera, Cristina, et al.
Publicado: (2014)

Sensory deficit screen identifies nsf mutation that differentially affects SNARE recycling and quality control
por: Gao, Yan, et al.
Publicado: (2023)

Recent establishment of tick-borne encephalitis foci with distinct viral lineages in the Helsinki area, Finland
por: Smura, Teemu, et al.
Publicado: (2019)

Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase
por: Karandur, Deepti, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_pjkcdrmelfd2q9kll9ciotlhkp