Cargando…

Elucidating the role of furin cleavage in SARS CoV-2 spike allostery using molecular dynamics simulations

Detalles Bibliográficos
Autores principales:	Mani, Natesan, Suresh, Raghavendran, Chakraborty, Srirupa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Biophysical Society. Published by Elsevier Inc. 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9912917/ http://dx.doi.org/10.1016/j.bpj.2022.11.1154

Ejemplares similares

Impact of mutations near the SARS-CoV-2 furin-cleavage site on viral infectivity
por: Nguyen, Kien, et al.
Publicado: (2022)

The Emergence of the Spike Furin Cleavage Site in SARS-CoV-2
por: Chan, Yujia Alina, et al.
Publicado: (2021)

Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation
por: Zhang, Liping, et al.
Publicado: (2021)

Furin cleavage of the SARS-CoV-2 spike is modulated by O-glycosylation
por: Zhang, Liping, et al.
Publicado: (2021)

SARS-CoV-2 spike and its adaptable furin cleavage site
por: Whittaker, Gary R
Publicado: (2021)

Natural Polymorphisms Are Present in the Furin Cleavage Site of the SARS-CoV-2 Spike Glycoprotein
por: Xing, Yue, et al.
Publicado: (2020)

Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion
por: Papa, Guido, et al.
Publicado: (2021)

SARS-CoV-2 omicron spike simulations: broad antibody escape, weakened ACE2 binding, and modest furin cleavage
por: Jawaid, M. Zaki, et al.
Publicado: (2023)

SARS-CoV-2 furin cleavage site was not engineered
por: Garry, Robert F.
Publicado: (2022)

Propagation of SARS-CoV-2 in Calu-3 Cells to Eliminate Mutations in the Furin Cleavage Site of Spike
por: Baczenas, John James, et al.
Publicado: (2021)

Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis
por: Johnson, Bryan A., et al.
Publicado: (2020)

Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects
por: Cheng, Ya-Wen, et al.
Publicado: (2020)

Essential Dynamics that Drive Sars-Cov-2 Spike Conformational Changes
por: Chakraborty, Srirupa, et al.
Publicado: (2021)

A novel antibody against the furin cleavage site of SARS-CoV-2 spike protein: Effects on proteolytic cleavage and ACE2 binding
por: Spelios, Michael G., et al.
Publicado: (2022)

The role of furin cleavage site in SARS-CoV-2 spike protein-mediated membrane fusion in the presence or absence of trypsin
por: Xia, Shuai, et al.
Publicado: (2020)

The sequence at Spike S1/S2 site enables cleavage by furin and phospho-regulation in SARS-CoV2 but not in SARS-CoV1 or MERS-CoV
por: Örd, Mihkel, et al.
Publicado: (2020)

The SARS-CoV-2 Transcriptome and the Dynamics of the S Gene Furin Cleavage Site in Primary Human Airway Epithelia
por: Zou, Wei, et al.
Publicado: (2021)

The SARS-CoV-2 furin cleavage site: natural selection or smoking gun?
por: Lubinski, Bailey, et al.
Publicado: (2023)

Probable human origin of the SARS-CoV-2 polybasic furin cleavage motif
por: Romeu, Antonio R.
Publicado: (2023)

Furin cleavage of the SARS coronavirus spike glycoprotein enhances cell–cell fusion but does not affect virion entry
por: Follis, Kathryn E., et al.
Publicado: (2006)

D614G Substitution of SARS-CoV-2 Spike Protein Increases Syncytium Formation and Virus Titer via Enhanced Furin-Mediated Spike Cleavage
por: Cheng, Ya-Wen, et al.
Publicado: (2021)

Evolutionary dynamics of SARS-CoV-2 circulating in Yogyakarta and Central Java, Indonesia: sequence analysis covering furin cleavage site (FCS) region of the spike protein
por: Wijayanti, Nastiti, et al.
Publicado: (2022)

Alpha-Soluble NSF Attachment Protein Prevents the Cleavage of the SARS-CoV-2 Spike Protein by Functioning as an Interferon-Upregulated Furin Inhibitor
por: Wang, Jinliang, et al.
Publicado: (2022)

Author Correction: SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects
por: Wrobel, Antoni G., et al.
Publicado: (2020)

Delving deep into the structural aspects of a furin cleavage site inserted into the spike protein of SARS-CoV-2: A structural biophysical perspective
por: Li, Wei
Publicado: (2020)

SARS-CoV-2 Spike Furin Cleavage Site and S2′ Basic Residues Modulate the Entry Process in a Host Cell-Dependent Manner
por: Lavie, Muriel, et al.
Publicado: (2022)

The D614G mutation redirects SARS-CoV-2 spike to lysosomes and suppresses deleterious traits of the furin cleavage site insertion mutation
por: Guo, Chenxu, et al.
Publicado: (2022)

A second functional furin site in the SARS-CoV-2 spike protein
por: Zhang, Yue, et al.
Publicado: (2022)

Furin cleavage sites naturally occur in coronaviruses
por: Wu, Yiran, et al.
Publicado: (2021)

Evolutionary insights into the furin cleavage sites of SARS-CoV-2 variants from humans and animals
por: Nagy, Abdou, et al.
Publicado: (2021)

Identification of an immunogenic epitope and protective antibody against the furin cleavage site of SARS-CoV-2
por: Li, Lili, et al.
Publicado: (2022)

Genomic determinants of Furin cleavage in diverse European SARS-related bat coronaviruses
por: Sander, Anna-Lena, et al.
Publicado: (2022)

Loss of furin site enhances SARS-CoV-2 spike protein pseudovirus infection
por: Wang, Zeng, et al.
Publicado: (2023)

Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein
por: Davidson, Andrew D., et al.
Publicado: (2020)

Metalloproteinase-Dependent and TMPRSS2-Independent Cell Surface Entry Pathway of SARS-CoV-2 Requires the Furin Cleavage Site and the S2 Domain of Spike Protein
por: Yamamoto, Mizuki, et al.
Publicado: (2022)

Investigation on the processing and improving the cleavage efficiency of furin cleavage sites in Pichia pastoris
por: Huang, Yide, et al.
Publicado: (2018)

Global Diversification and Distribution of Coronaviruses With Furin Cleavage Sites
por: Liu, Xiaotong, et al.
Publicado: (2021)

Furin cleavage is required for swine acute diarrhea syndrome coronavirus spike protein-mediated cell – cell fusion
por: Kim, Jinman, et al.
Publicado: (2022)

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
por: Vuckovic, Ziva, et al.
Publicado: (2023)

FurinDB: A Database of 20-Residue Furin Cleavage Site Motifs, Substrates and Their Associated Drugs
por: Tian, Sun, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_4e301t5dal1dv8b5si5bo34c55