Hybridised production of technetium-99m and technetium-101 with fluorine-18 on a low-energy biomedical cyclotron

New modes of production and supply of short-lived radioisotopes using accelerators are becoming attractive alternatives to the use of nuclear reactors. In this study, the use of a compact accelerator neutron source (CANS) was implemented to explore the production of (99m)Tc and (101)Tc. Irradiations...

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Detalles Bibliográficos
Autores principales: Johnstone, Erik V., Mayordomo, Natalia, Mausolf, Edward J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913010/
https://www.ncbi.nlm.nih.gov/pubmed/36817092
http://dx.doi.org/10.1140/epjti/s40485-023-00089-2
Descripción
Sumario:New modes of production and supply of short-lived radioisotopes using accelerators are becoming attractive alternatives to the use of nuclear reactors. In this study, the use of a compact accelerator neutron source (CANS) was implemented to explore the production of (99m)Tc and (101)Tc. Irradiations were performed with neutrons generated from a 16.5 MeV cyclotron utilising the (18)O(p, n)(18)F reaction during routine (18)F-fluorodeoxyglucose (FDG) production in a commercial radiopharmacy. Natural molybdenum targets in metal form were employed for the production of several Tc isotopes interest via (n, γ) reactions on (98)Mo and (100)Mo. The production of (99m)Tc and (101)Tc under these conditions is considered and discussed.

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