Hybridised production of technetium-99m and technetium-101 with fluorine-18 on a low-energy biomedical cyclotron

New modes of production and supply of short-lived radioisotopes using accelerators are becoming attractive alternatives to the use of nuclear reactors. In this study, the use of a compact accelerator neutron source (CANS) was implemented to explore the production of (99m)Tc and (101)Tc. Irradiations...

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Detalles Bibliográficos
Autores principales: Johnstone, Erik V., Mayordomo, Natalia, Mausolf, Edward J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913010/
https://www.ncbi.nlm.nih.gov/pubmed/36817092
http://dx.doi.org/10.1140/epjti/s40485-023-00089-2
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author Johnstone, Erik V.
Mayordomo, Natalia
Mausolf, Edward J.
author_facet Johnstone, Erik V.
Mayordomo, Natalia
Mausolf, Edward J.
author_sort Johnstone, Erik V.
collection PubMed
description New modes of production and supply of short-lived radioisotopes using accelerators are becoming attractive alternatives to the use of nuclear reactors. In this study, the use of a compact accelerator neutron source (CANS) was implemented to explore the production of (99m)Tc and (101)Tc. Irradiations were performed with neutrons generated from a 16.5 MeV cyclotron utilising the (18)O(p, n)(18)F reaction during routine (18)F-fluorodeoxyglucose (FDG) production in a commercial radiopharmacy. Natural molybdenum targets in metal form were employed for the production of several Tc isotopes interest via (n, γ) reactions on (98)Mo and (100)Mo. The production of (99m)Tc and (101)Tc under these conditions is considered and discussed.
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spelling pubmed-99130102023-02-13 Hybridised production of technetium-99m and technetium-101 with fluorine-18 on a low-energy biomedical cyclotron Johnstone, Erik V. Mayordomo, Natalia Mausolf, Edward J. EPJ Tech Instrum Research Article New modes of production and supply of short-lived radioisotopes using accelerators are becoming attractive alternatives to the use of nuclear reactors. In this study, the use of a compact accelerator neutron source (CANS) was implemented to explore the production of (99m)Tc and (101)Tc. Irradiations were performed with neutrons generated from a 16.5 MeV cyclotron utilising the (18)O(p, n)(18)F reaction during routine (18)F-fluorodeoxyglucose (FDG) production in a commercial radiopharmacy. Natural molybdenum targets in metal form were employed for the production of several Tc isotopes interest via (n, γ) reactions on (98)Mo and (100)Mo. The production of (99m)Tc and (101)Tc under these conditions is considered and discussed. Springer Berlin Heidelberg 2023-02-10 2023 /pmc/articles/PMC9913010/ /pubmed/36817092 http://dx.doi.org/10.1140/epjti/s40485-023-00089-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Article
Johnstone, Erik V.
Mayordomo, Natalia
Mausolf, Edward J.
Hybridised production of technetium-99m and technetium-101 with fluorine-18 on a low-energy biomedical cyclotron
title Hybridised production of technetium-99m and technetium-101 with fluorine-18 on a low-energy biomedical cyclotron
title_full Hybridised production of technetium-99m and technetium-101 with fluorine-18 on a low-energy biomedical cyclotron
title_fullStr Hybridised production of technetium-99m and technetium-101 with fluorine-18 on a low-energy biomedical cyclotron
title_full_unstemmed Hybridised production of technetium-99m and technetium-101 with fluorine-18 on a low-energy biomedical cyclotron
title_short Hybridised production of technetium-99m and technetium-101 with fluorine-18 on a low-energy biomedical cyclotron
title_sort hybridised production of technetium-99m and technetium-101 with fluorine-18 on a low-energy biomedical cyclotron
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913010/
https://www.ncbi.nlm.nih.gov/pubmed/36817092
http://dx.doi.org/10.1140/epjti/s40485-023-00089-2
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