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An Optimized Single Nucleotide Polymorphism-Based Detection Method Suggests That Allelic Variants in the 3’ Untranslated Region of RRAS2 Correlate with Treatment Response in Chronic Lymphocytic Leukemia Patients

SIMPLE SUMMARY: Overexpression of unmutated RRAS2 could be behind the development of chronic lymphocytic leukemia (CLL). This is, in part, supported by the presence of a single-nucleotide polymorphism (SNP) in the 3’ untranslated region of the RRAS2 mRNA that is linked to higher RRAS2 overexpression...

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Detalles Bibliográficos
Autores principales:	Hortal, Alejandro, Lacuna, Marta, Cifuentes, Claudia, Alcoceba, Miguel, Bustelo, Xosé R., González, Marcos, Alarcón, Balbino
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913312/ https://www.ncbi.nlm.nih.gov/pubmed/36765602 http://dx.doi.org/10.3390/cancers15030644

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