Cargando…

Pharmacokinetic Analysis of Omomyc Shows Lasting Structural Integrity and Long Terminal Half-Life in Tumor Tissue

SIMPLE SUMMARY: The maintenance of the structural integrity of therapeutic proteins in the target tissue is crucial to their proper function. In this study, we aimed to assess the in vivo stability of the therapeutic protein Omomyc in blood serum and tumor tissue in a xenograft mouse model of colore...

Descripción completa

Detalles Bibliográficos
Autores principales:	Beaulieu, Marie-Eve, Martínez-Martín, Sandra, Kaur, Jastrinjan, Castillo Cano, Virginia, Massó-Vallés, Daniel, Foradada Felip, Laia, López-Estévez, Sergio, Serrano del Pozo, Erika, Thabussot, Hugo, Soucek, Laura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913332/ https://www.ncbi.nlm.nih.gov/pubmed/36765784 http://dx.doi.org/10.3390/cancers15030826

Ejemplares similares

Blocking Myc to Treat Cancer: Reflecting on Two Decades of Omomyc
por: Massó-Vallés, Daniel, et al.
Publicado: (2020)

Reducing MYC's transcriptional footprint unveils a good prognostic gene signature in melanoma
por: Zacarías-Fluck, Mariano F., et al.
Publicado: (2023)

BET inhibition is an effective approach against KRAS-driven PDAC and NSCLC
por: Jauset, Toni, et al.
Publicado: (2018)

MYC Inhibition Halts Metastatic Breast Cancer Progression by Blocking Growth, Invasion, and Seeding
por: Massó-Vallés, Daniel, et al.
Publicado: (2022)

Omomyc Reveals New Mechanisms To Inhibit the MYC Oncogene
por: Demma, Mark J., et al.
Publicado: (2019)

The Action Mechanism of the Myc Inhibitor Termed Omomyc May Give Clues on How to Target Myc for Cancer Therapy
por: Savino, Mauro, et al.
Publicado: (2011)

The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets
por: Zacarías-Fluck, Mariano F, et al.
Publicado: (2021)

Myc and Omomyc functionally associate with the Protein Arginine Methyltransferase 5 (PRMT5) in glioblastoma cells
por: Mongiardi, Maria Patrizia, et al.
Publicado: (2015)

Ibrutinib repurposing: from B-cell malignancies to solid tumors
por: Massó-Vallés, Daniel, et al.
Publicado: (2016)

Finding MYCure
por: Beaulieu, Marie-Eve, et al.
Publicado: (2019)

Structural and Biophysical Insights into the Function of the Intrinsically Disordered Myc Oncoprotein
por: Beaulieu, Marie-Eve, et al.
Publicado: (2020)

The last picture show
Publicado: (1999)

Elimination of diarrheal mortality in children – the last half million
por: Santosham, Mathuram, et al.
Publicado: (2019)

Strategies to Inhibit Myc and Their Clinical Applicability
por: Whitfield, Jonathan R., et al.
Publicado: (2017)

Targeting MYC-driven lymphoma: lessons learned and future directions
por: Martínez-Martín, Sandra, et al.
Publicado: (2023)

Myc inhibition is effective against glioma and reveals a role for Myc in proficient mitosis
por: Annibali, Daniela, et al.
Publicado: (2014)

Evaporation abrupt changes in the Qinghai-Tibet Plateau during the last half-century
por: Yao, Tianci, et al.
Publicado: (2019)

Drivers and distribution of global ocean heat uptake over the last half century
por: Huguenin, Maurice F., et al.
Publicado: (2022)

Calcium-controlled conformational choreography in the N-terminal half of adseverin
por: Chumnarnsilpa, Sakesit, et al.
Publicado: (2015)

Predicting Individual Changes in Terminal Half-Life After Switching to Extended Half-Life Concentrates in Patients With Severe Hemophilia
por: Versloot, Olav, et al.
Publicado: (2022)

Quantum Chemical Lipophilicities of Antimalarial Drugs in Relation to Terminal Half-Life
por: Alia, Joseph D., et al.
Publicado: (2020)

Potential Role of the Last Half Repeat in TAL Effectors Revealed by a Molecular Simulation Study
por: Wan, Hua, et al.
Publicado: (2016)

Spatial and habitat variation in aphid, butterfly, moth and bird phenologies over the last half century
por: Bell, James R., et al.
Publicado: (2019)

Drought characteristics and its elevation dependence in the Qinghai–Tibet plateau during the last half-century
por: Feng, Wei, et al.
Publicado: (2020)

Functional analyses of the C-terminal half of the Saccharomyces cerevisiae Rad52 protein
por: Kagawa, Wataru, et al.
Publicado: (2014)

Evolution of tropical land temperature across the last glacial termination
por: Løland, M. H., et al.
Publicado: (2022)

Nucleobindin-2 consists of two structural components: The Zn(2+)-sensitive N-terminal half, consisting of nesfatin-1 and -2, and the Ca(2+)-sensitive C-terminal half, consisting of nesfatin-3
por: Bystranowska, Dominika, et al.
Publicado: (2021)

Half-and-half nails
por: Gandhi, K., et al.
Publicado: (2014)

Half and half nails
por: Neild, G. H., et al.
Publicado: (2011)

Half and half nail
por: Avhad, Ganesh, et al.
Publicado: (2014)

Half-and-Half Palatoplasty
por: Han, Hyun Ho, et al.
Publicado: (2014)

An intact C-terminal end of albumin is required for its long half-life in humans
por: Nilsen, Jeannette, et al.
Publicado: (2020)

5′ Untranslated Region Elements Show High Abundance and Great Variability in Homologous ABCA Subfamily Genes
por: Dvorak, Pavel, et al.
Publicado: (2020)

Change in atmospheric deposition during last half century and its impact on lichen community structure in Eastern Himalaya
por: Bajpai, Rajesh, et al.
Publicado: (2016)

Phylogeographical analysis shows the need to protect the wild yaks' last refuge in Nepal
por: Kusi, Naresh, et al.
Publicado: (2021)

Life on the edge—a changing genetic landscape within an iconic American pika metapopulation over the last half century
por: Klingler, Kelly B., et al.
Publicado: (2023)

Is the glass half full or half empty?
por: Abdullah, BJJ, et al.
Publicado: (2007)

Is the glass half full or half empty?
por: Association
Publicado: (2006)

Submarine landslide megablocks show half of Anak Krakatau island failed on December 22nd, 2018
por: Hunt, J. E., et al.
Publicado: (2021)

Quantitative evaluation of large corporate climate action initiatives shows mixed progress in their first half-decade
por: Ruiz Manuel, Ivan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_a746i08dc8bpeod9o35i9aa80h