Inhibition of Abl Kinase by Imatinib Can Rescue the Compromised Barrier Function of 22q11.2DS Patient-iPSC-Derived Blood–Brain Barriers

We have previously established that the integrity of the induced blood–brain barrier (iBBB) formed by brain microvascular endothelial cells derived from the iPSC of 22q11.2 DS (22q11.2 Deletion Syndrome, also called DiGeorge Syndrome) patients is compromised. We tested the possibility that the haplo...

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Detalles Bibliográficos
Autores principales: Li, Yunfei, Sun, Zhixiong, Zhu, Huixiang, Sun, Yan, Shteyman, David B., Markx, Sander, Leong, Kam W., Xu, Bin, Fu, Bingmei M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913366/
https://www.ncbi.nlm.nih.gov/pubmed/36766762
http://dx.doi.org/10.3390/cells12030422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913366/
https://www.ncbi.nlm.nih.gov/pubmed/36766762
http://dx.doi.org/10.3390/cells12030422

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