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S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains

Protein lipidation is a common post-translational modification of proteins that plays an important role in human physiology and pathology. One form of protein lipidation, S-palmitoylation, involves the addition of a 16-carbon fatty acid (palmitate) onto proteins. This reversible modification may aff...

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Detalles Bibliográficos
Autores principales: Buszka, Anna, Pytyś, Agata, Colvin, Domnic, Włodarczyk, Jakub, Wójtowicz, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913408/
https://www.ncbi.nlm.nih.gov/pubmed/36766729
http://dx.doi.org/10.3390/cells12030387
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author Buszka, Anna
Pytyś, Agata
Colvin, Domnic
Włodarczyk, Jakub
Wójtowicz, Tomasz
author_facet Buszka, Anna
Pytyś, Agata
Colvin, Domnic
Włodarczyk, Jakub
Wójtowicz, Tomasz
author_sort Buszka, Anna
collection PubMed
description Protein lipidation is a common post-translational modification of proteins that plays an important role in human physiology and pathology. One form of protein lipidation, S-palmitoylation, involves the addition of a 16-carbon fatty acid (palmitate) onto proteins. This reversible modification may affect the regulation of protein trafficking and stability in membranes. From multiple recent experimental studies, a picture emerges whereby protein S-palmitoylation is a ubiquitous yet discrete molecular switch enabling the expansion of protein functions and subcellular localization in minutes to hours. Neural tissue is particularly rich in proteins that are regulated by S-palmitoylation. A surge of novel methods of detection of protein lipidation at high resolution allowed us to get better insights into the roles of protein palmitoylation in brain physiology and pathophysiology. In this review, we specifically discuss experimental work devoted to understanding the impact of protein palmitoylation on functional changes in the excitatory and inhibitory synapses associated with neuronal activity and neuronal plasticity. The accumulated evidence also implies a crucial role of S-palmitoylation in learning and memory, and brain disorders associated with impaired cognitive functions.
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spelling pubmed-99134082023-02-11 S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains Buszka, Anna Pytyś, Agata Colvin, Domnic Włodarczyk, Jakub Wójtowicz, Tomasz Cells Review Protein lipidation is a common post-translational modification of proteins that plays an important role in human physiology and pathology. One form of protein lipidation, S-palmitoylation, involves the addition of a 16-carbon fatty acid (palmitate) onto proteins. This reversible modification may affect the regulation of protein trafficking and stability in membranes. From multiple recent experimental studies, a picture emerges whereby protein S-palmitoylation is a ubiquitous yet discrete molecular switch enabling the expansion of protein functions and subcellular localization in minutes to hours. Neural tissue is particularly rich in proteins that are regulated by S-palmitoylation. A surge of novel methods of detection of protein lipidation at high resolution allowed us to get better insights into the roles of protein palmitoylation in brain physiology and pathophysiology. In this review, we specifically discuss experimental work devoted to understanding the impact of protein palmitoylation on functional changes in the excitatory and inhibitory synapses associated with neuronal activity and neuronal plasticity. The accumulated evidence also implies a crucial role of S-palmitoylation in learning and memory, and brain disorders associated with impaired cognitive functions. MDPI 2023-01-21 /pmc/articles/PMC9913408/ /pubmed/36766729 http://dx.doi.org/10.3390/cells12030387 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Buszka, Anna
Pytyś, Agata
Colvin, Domnic
Włodarczyk, Jakub
Wójtowicz, Tomasz
S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains
title S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains
title_full S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains
title_fullStr S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains
title_full_unstemmed S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains
title_short S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains
title_sort s-palmitoylation of synaptic proteins in neuronal plasticity in normal and pathological brains
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913408/
https://www.ncbi.nlm.nih.gov/pubmed/36766729
http://dx.doi.org/10.3390/cells12030387
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