Cargando…
S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains
Protein lipidation is a common post-translational modification of proteins that plays an important role in human physiology and pathology. One form of protein lipidation, S-palmitoylation, involves the addition of a 16-carbon fatty acid (palmitate) onto proteins. This reversible modification may aff...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913408/ https://www.ncbi.nlm.nih.gov/pubmed/36766729 http://dx.doi.org/10.3390/cells12030387 |
_version_ | 1784885420041961472 |
---|---|
author | Buszka, Anna Pytyś, Agata Colvin, Domnic Włodarczyk, Jakub Wójtowicz, Tomasz |
author_facet | Buszka, Anna Pytyś, Agata Colvin, Domnic Włodarczyk, Jakub Wójtowicz, Tomasz |
author_sort | Buszka, Anna |
collection | PubMed |
description | Protein lipidation is a common post-translational modification of proteins that plays an important role in human physiology and pathology. One form of protein lipidation, S-palmitoylation, involves the addition of a 16-carbon fatty acid (palmitate) onto proteins. This reversible modification may affect the regulation of protein trafficking and stability in membranes. From multiple recent experimental studies, a picture emerges whereby protein S-palmitoylation is a ubiquitous yet discrete molecular switch enabling the expansion of protein functions and subcellular localization in minutes to hours. Neural tissue is particularly rich in proteins that are regulated by S-palmitoylation. A surge of novel methods of detection of protein lipidation at high resolution allowed us to get better insights into the roles of protein palmitoylation in brain physiology and pathophysiology. In this review, we specifically discuss experimental work devoted to understanding the impact of protein palmitoylation on functional changes in the excitatory and inhibitory synapses associated with neuronal activity and neuronal plasticity. The accumulated evidence also implies a crucial role of S-palmitoylation in learning and memory, and brain disorders associated with impaired cognitive functions. |
format | Online Article Text |
id | pubmed-9913408 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99134082023-02-11 S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains Buszka, Anna Pytyś, Agata Colvin, Domnic Włodarczyk, Jakub Wójtowicz, Tomasz Cells Review Protein lipidation is a common post-translational modification of proteins that plays an important role in human physiology and pathology. One form of protein lipidation, S-palmitoylation, involves the addition of a 16-carbon fatty acid (palmitate) onto proteins. This reversible modification may affect the regulation of protein trafficking and stability in membranes. From multiple recent experimental studies, a picture emerges whereby protein S-palmitoylation is a ubiquitous yet discrete molecular switch enabling the expansion of protein functions and subcellular localization in minutes to hours. Neural tissue is particularly rich in proteins that are regulated by S-palmitoylation. A surge of novel methods of detection of protein lipidation at high resolution allowed us to get better insights into the roles of protein palmitoylation in brain physiology and pathophysiology. In this review, we specifically discuss experimental work devoted to understanding the impact of protein palmitoylation on functional changes in the excitatory and inhibitory synapses associated with neuronal activity and neuronal plasticity. The accumulated evidence also implies a crucial role of S-palmitoylation in learning and memory, and brain disorders associated with impaired cognitive functions. MDPI 2023-01-21 /pmc/articles/PMC9913408/ /pubmed/36766729 http://dx.doi.org/10.3390/cells12030387 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Buszka, Anna Pytyś, Agata Colvin, Domnic Włodarczyk, Jakub Wójtowicz, Tomasz S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains |
title | S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains |
title_full | S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains |
title_fullStr | S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains |
title_full_unstemmed | S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains |
title_short | S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains |
title_sort | s-palmitoylation of synaptic proteins in neuronal plasticity in normal and pathological brains |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913408/ https://www.ncbi.nlm.nih.gov/pubmed/36766729 http://dx.doi.org/10.3390/cells12030387 |
work_keys_str_mv | AT buszkaanna spalmitoylationofsynapticproteinsinneuronalplasticityinnormalandpathologicalbrains AT pytysagata spalmitoylationofsynapticproteinsinneuronalplasticityinnormalandpathologicalbrains AT colvindomnic spalmitoylationofsynapticproteinsinneuronalplasticityinnormalandpathologicalbrains AT włodarczykjakub spalmitoylationofsynapticproteinsinneuronalplasticityinnormalandpathologicalbrains AT wojtowicztomasz spalmitoylationofsynapticproteinsinneuronalplasticityinnormalandpathologicalbrains |