P38 Mediates Tumor Suppression through Reduced Autophagy and Actin Cytoskeleton Changes in NRAS-Mutant Melanoma

SIMPLE SUMMARY: Mutations in NRAS are the second most common driver mutation in melanoma and lack therapy options. We discovered that p38 plays the role of a tumor suppressor in NRAS mutant melanoma. In this study, we characterized the significance of short and long term p38 activation which can in...

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Detalles Bibliográficos
Autores principales: Banik, Ishani, Ghosh, Adhideb, Beebe, Erin, Burja, Blaž, Bertoncelj, Mojca Frank, Dooley, Christopher M., Markkanen, Enni, Dummer, Reinhard, Busch-Nentwich, Elisabeth M., Levesque, Mitchell P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913513/
https://www.ncbi.nlm.nih.gov/pubmed/36765834
http://dx.doi.org/10.3390/cancers15030877

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