Immunomodulation of Natural Killer Cell Function by Ribavirin Involves TYK-2 Activation and Subsequent Increased IFN-γ Secretion in the Context of In Vitro Hepatitis E Virus Infection

Hepatitis E virus (HEV) is a major cause of acute hepatitis globally. Chronic and fulminant courses are observed especially in immunocompromised transplant recipients since administration of ribavirin (RBV) does not always lead to a sustained virologic response. By in vitro stimulation of NK cells t...

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Detalles Bibliográficos
Autores principales: Kupke, Paul, Adenugba, Akinbami, Schemmerer, Mathias, Bitterer, Florian, Schlitt, Hans J., Geissler, Edward K., Wenzel, Jürgen J., Werner, Jens M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913562/
https://www.ncbi.nlm.nih.gov/pubmed/36766795
http://dx.doi.org/10.3390/cells12030453

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