Cargando…

Immunotherapy: Review of the Existing Evidence and Challenges in Breast Cancer

SIMPLE SUMMARY: Breast cancer is one of the most common malignant tumors in women. Its incidence rate accounts for 7–10% of all kinds of malignant tumors in the whole body, second only to uterine cancer in women, and has become the main cancer threatening women’s health. Fortunately, it has been pro...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Yun, Li, Yan, Yao, Zhangcheng, Huang, Fenglin, Cai, Hongzhou, Liu, Hanyuan, Zhang, Xiaoyi, Zhang, Junying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913569/
https://www.ncbi.nlm.nih.gov/pubmed/36765522
http://dx.doi.org/10.3390/cancers15030563
_version_ 1784885459295404032
author Hu, Yun
Li, Yan
Yao, Zhangcheng
Huang, Fenglin
Cai, Hongzhou
Liu, Hanyuan
Zhang, Xiaoyi
Zhang, Junying
author_facet Hu, Yun
Li, Yan
Yao, Zhangcheng
Huang, Fenglin
Cai, Hongzhou
Liu, Hanyuan
Zhang, Xiaoyi
Zhang, Junying
author_sort Hu, Yun
collection PubMed
description SIMPLE SUMMARY: Breast cancer is one of the most common malignant tumors in women. Its incidence rate accounts for 7–10% of all kinds of malignant tumors in the whole body, second only to uterine cancer in women, and has become the main cancer threatening women’s health. Fortunately, it has been proved that combination therapy of immunotherapy with radiotherapy, targeted technology, and even nanotechnology is active and effective in treating breast cancer, which provides a broader way of studying the treatment of breast cancer. Therefore, the purpose of our review is to study the value of immunotherapy in breast cancer treatment. Moreover, because the treatment of triple-negative breast cancer (TNBC) is difficult, we will discuss this in more detail in this article. ABSTRACT: Breast cancer (BC) is a representative malignant tumor that affects women across the world, and it is the main cause of cancer-related deaths in women. Although a large number of treatment methods have been developed for BC in recent years, the results are sometimes unsatisfying. In recent years, treatments of BC have been expanded with immunotherapy. In our article, we list some tumor markers related to immunotherapy for BC. Moreover, we introduce the existing relatively mature immunotherapy and the markers’ pathogenesis are involved. The combination of immunotherapy and other therapies for BC are introduced in detail, including the combination of immunotherapy and chemotherapy, the combined use of immunosuppressants and chemotherapy drugs, immunotherapy and molecular targeted therapy. We summarize the clinical effects of these methods. In addition, this paper also makes a preliminary exploration of the combination of immunotherapy, radiotherapy, and nanotechnology for BC.
format Online
Article
Text
id pubmed-9913569
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99135692023-02-11 Immunotherapy: Review of the Existing Evidence and Challenges in Breast Cancer Hu, Yun Li, Yan Yao, Zhangcheng Huang, Fenglin Cai, Hongzhou Liu, Hanyuan Zhang, Xiaoyi Zhang, Junying Cancers (Basel) Review SIMPLE SUMMARY: Breast cancer is one of the most common malignant tumors in women. Its incidence rate accounts for 7–10% of all kinds of malignant tumors in the whole body, second only to uterine cancer in women, and has become the main cancer threatening women’s health. Fortunately, it has been proved that combination therapy of immunotherapy with radiotherapy, targeted technology, and even nanotechnology is active and effective in treating breast cancer, which provides a broader way of studying the treatment of breast cancer. Therefore, the purpose of our review is to study the value of immunotherapy in breast cancer treatment. Moreover, because the treatment of triple-negative breast cancer (TNBC) is difficult, we will discuss this in more detail in this article. ABSTRACT: Breast cancer (BC) is a representative malignant tumor that affects women across the world, and it is the main cause of cancer-related deaths in women. Although a large number of treatment methods have been developed for BC in recent years, the results are sometimes unsatisfying. In recent years, treatments of BC have been expanded with immunotherapy. In our article, we list some tumor markers related to immunotherapy for BC. Moreover, we introduce the existing relatively mature immunotherapy and the markers’ pathogenesis are involved. The combination of immunotherapy and other therapies for BC are introduced in detail, including the combination of immunotherapy and chemotherapy, the combined use of immunosuppressants and chemotherapy drugs, immunotherapy and molecular targeted therapy. We summarize the clinical effects of these methods. In addition, this paper also makes a preliminary exploration of the combination of immunotherapy, radiotherapy, and nanotechnology for BC. MDPI 2023-01-17 /pmc/articles/PMC9913569/ /pubmed/36765522 http://dx.doi.org/10.3390/cancers15030563 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hu, Yun
Li, Yan
Yao, Zhangcheng
Huang, Fenglin
Cai, Hongzhou
Liu, Hanyuan
Zhang, Xiaoyi
Zhang, Junying
Immunotherapy: Review of the Existing Evidence and Challenges in Breast Cancer
title Immunotherapy: Review of the Existing Evidence and Challenges in Breast Cancer
title_full Immunotherapy: Review of the Existing Evidence and Challenges in Breast Cancer
title_fullStr Immunotherapy: Review of the Existing Evidence and Challenges in Breast Cancer
title_full_unstemmed Immunotherapy: Review of the Existing Evidence and Challenges in Breast Cancer
title_short Immunotherapy: Review of the Existing Evidence and Challenges in Breast Cancer
title_sort immunotherapy: review of the existing evidence and challenges in breast cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913569/
https://www.ncbi.nlm.nih.gov/pubmed/36765522
http://dx.doi.org/10.3390/cancers15030563
work_keys_str_mv AT huyun immunotherapyreviewoftheexistingevidenceandchallengesinbreastcancer
AT liyan immunotherapyreviewoftheexistingevidenceandchallengesinbreastcancer
AT yaozhangcheng immunotherapyreviewoftheexistingevidenceandchallengesinbreastcancer
AT huangfenglin immunotherapyreviewoftheexistingevidenceandchallengesinbreastcancer
AT caihongzhou immunotherapyreviewoftheexistingevidenceandchallengesinbreastcancer
AT liuhanyuan immunotherapyreviewoftheexistingevidenceandchallengesinbreastcancer
AT zhangxiaoyi immunotherapyreviewoftheexistingevidenceandchallengesinbreastcancer
AT zhangjunying immunotherapyreviewoftheexistingevidenceandchallengesinbreastcancer