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The Role of Aquaporin 5 (AQP5) in Lung Adenocarcinoma: A Review Article
Aquaporins (AQPs) are selective, transmembrane proteins, which are primarily responsible for the transport of water and small molecules. They have been demonstrated to play a key role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer diagnosed i...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913646/ https://www.ncbi.nlm.nih.gov/pubmed/36766810 http://dx.doi.org/10.3390/cells12030468 |
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author | Jaskiewicz, Lukasz Romaszko-Wojtowicz, Anna Doboszynska, Anna Skowronska, Agnieszka |
author_facet | Jaskiewicz, Lukasz Romaszko-Wojtowicz, Anna Doboszynska, Anna Skowronska, Agnieszka |
author_sort | Jaskiewicz, Lukasz |
collection | PubMed |
description | Aquaporins (AQPs) are selective, transmembrane proteins, which are primarily responsible for the transport of water and small molecules. They have been demonstrated to play a key role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer diagnosed in patients in Europe and the USA. The research done so far has provided firm evidence that some AQPs can be biomarkers for various diseases. The objective of this review article is to present a potential role of AQP5 in the development of lung adenocarcinoma. Original papers discussing the involvement of AQP5 in carcinogenesis and containing relevant clinical data were identified. In order to analyze the research material in accordance with PRISMA guidelines, a systematic search of the ScienceDirect, Web of Science, and Pubmed databases was conducted. Out of the total number of 199 papers identified, 14 original articles were subject to analysis. This article presents the pathophysiological role of AQP5 in the biology of lung adenocarcinoma as well as its prognostic value. The analysis substantiates the conclusion that the prognostic value of AQP5 in lung cancer requires further research. Another aim of this paper is to disseminate knowledge about AQPs among clinicians. |
format | Online Article Text |
id | pubmed-9913646 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99136462023-02-11 The Role of Aquaporin 5 (AQP5) in Lung Adenocarcinoma: A Review Article Jaskiewicz, Lukasz Romaszko-Wojtowicz, Anna Doboszynska, Anna Skowronska, Agnieszka Cells Review Aquaporins (AQPs) are selective, transmembrane proteins, which are primarily responsible for the transport of water and small molecules. They have been demonstrated to play a key role in the development and progression of cancer. Lung adenocarcinoma is the most common primary lung cancer diagnosed in patients in Europe and the USA. The research done so far has provided firm evidence that some AQPs can be biomarkers for various diseases. The objective of this review article is to present a potential role of AQP5 in the development of lung adenocarcinoma. Original papers discussing the involvement of AQP5 in carcinogenesis and containing relevant clinical data were identified. In order to analyze the research material in accordance with PRISMA guidelines, a systematic search of the ScienceDirect, Web of Science, and Pubmed databases was conducted. Out of the total number of 199 papers identified, 14 original articles were subject to analysis. This article presents the pathophysiological role of AQP5 in the biology of lung adenocarcinoma as well as its prognostic value. The analysis substantiates the conclusion that the prognostic value of AQP5 in lung cancer requires further research. Another aim of this paper is to disseminate knowledge about AQPs among clinicians. MDPI 2023-01-31 /pmc/articles/PMC9913646/ /pubmed/36766810 http://dx.doi.org/10.3390/cells12030468 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jaskiewicz, Lukasz Romaszko-Wojtowicz, Anna Doboszynska, Anna Skowronska, Agnieszka The Role of Aquaporin 5 (AQP5) in Lung Adenocarcinoma: A Review Article |
title | The Role of Aquaporin 5 (AQP5) in Lung Adenocarcinoma: A Review Article |
title_full | The Role of Aquaporin 5 (AQP5) in Lung Adenocarcinoma: A Review Article |
title_fullStr | The Role of Aquaporin 5 (AQP5) in Lung Adenocarcinoma: A Review Article |
title_full_unstemmed | The Role of Aquaporin 5 (AQP5) in Lung Adenocarcinoma: A Review Article |
title_short | The Role of Aquaporin 5 (AQP5) in Lung Adenocarcinoma: A Review Article |
title_sort | role of aquaporin 5 (aqp5) in lung adenocarcinoma: a review article |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913646/ https://www.ncbi.nlm.nih.gov/pubmed/36766810 http://dx.doi.org/10.3390/cells12030468 |
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