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Placental Changes and Neuropsychological Development in Children—A Systematic Review

Placental dysfunction may increase the offspring’s later-life disease risk. The objective of this systematic review was to describe associations between pathological placental changes and neuropsychological outcomes in children after the neonatal period. The inclusion criteria were human studies; or...

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Autores principales: Lodefalk, Maria, Chelslín, Felix, Patriksson Karlsson, Johanna, Hansson, Stefan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913696/
https://www.ncbi.nlm.nih.gov/pubmed/36766778
http://dx.doi.org/10.3390/cells12030435
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author Lodefalk, Maria
Chelslín, Felix
Patriksson Karlsson, Johanna
Hansson, Stefan R.
author_facet Lodefalk, Maria
Chelslín, Felix
Patriksson Karlsson, Johanna
Hansson, Stefan R.
author_sort Lodefalk, Maria
collection PubMed
description Placental dysfunction may increase the offspring’s later-life disease risk. The objective of this systematic review was to describe associations between pathological placental changes and neuropsychological outcomes in children after the neonatal period. The inclusion criteria were human studies; original research; direct placental variables; neuropsychological outcomes; and analysis between their associations. The exclusion criterion was the offspring’s age—0–28 days or >19 years. The MEDLINE and EMBASE databases were last searched in May 2022. We utilized the ROBINS-I for the risk of bias assessment and performed a narrative synthesis. In total, 3252 studies were identified, out of which 16 were included (i.e., a total of 15,862 participants). Half of the studies were performed on children with neonatal complications, and 75% of the studies reported an association between a placental change and an outcome; however, following the completion of the funnel plots, a risk of publication bias was indicated. The largest study described a small association between placental size and a risk of psychiatric symptoms in boys only. Inconsistency between the studies limited the evidence in this review. In general, no strong evidence was found for an association between pathological placental changes and childhood neuropsychological outcomes after the neonatal period. However, the association between placental size and mental health in boys indicates a placental sexual dimorphism, thereby suggesting an increased vulnerability for male fetuses.
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spelling pubmed-99136962023-02-11 Placental Changes and Neuropsychological Development in Children—A Systematic Review Lodefalk, Maria Chelslín, Felix Patriksson Karlsson, Johanna Hansson, Stefan R. Cells Systematic Review Placental dysfunction may increase the offspring’s later-life disease risk. The objective of this systematic review was to describe associations between pathological placental changes and neuropsychological outcomes in children after the neonatal period. The inclusion criteria were human studies; original research; direct placental variables; neuropsychological outcomes; and analysis between their associations. The exclusion criterion was the offspring’s age—0–28 days or >19 years. The MEDLINE and EMBASE databases were last searched in May 2022. We utilized the ROBINS-I for the risk of bias assessment and performed a narrative synthesis. In total, 3252 studies were identified, out of which 16 were included (i.e., a total of 15,862 participants). Half of the studies were performed on children with neonatal complications, and 75% of the studies reported an association between a placental change and an outcome; however, following the completion of the funnel plots, a risk of publication bias was indicated. The largest study described a small association between placental size and a risk of psychiatric symptoms in boys only. Inconsistency between the studies limited the evidence in this review. In general, no strong evidence was found for an association between pathological placental changes and childhood neuropsychological outcomes after the neonatal period. However, the association between placental size and mental health in boys indicates a placental sexual dimorphism, thereby suggesting an increased vulnerability for male fetuses. MDPI 2023-01-28 /pmc/articles/PMC9913696/ /pubmed/36766778 http://dx.doi.org/10.3390/cells12030435 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Lodefalk, Maria
Chelslín, Felix
Patriksson Karlsson, Johanna
Hansson, Stefan R.
Placental Changes and Neuropsychological Development in Children—A Systematic Review
title Placental Changes and Neuropsychological Development in Children—A Systematic Review
title_full Placental Changes and Neuropsychological Development in Children—A Systematic Review
title_fullStr Placental Changes and Neuropsychological Development in Children—A Systematic Review
title_full_unstemmed Placental Changes and Neuropsychological Development in Children—A Systematic Review
title_short Placental Changes and Neuropsychological Development in Children—A Systematic Review
title_sort placental changes and neuropsychological development in children—a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913696/
https://www.ncbi.nlm.nih.gov/pubmed/36766778
http://dx.doi.org/10.3390/cells12030435
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