Pancreatic Cancer Incidence Trends by Race, Ethnicity, Age and Sex in the United States: A Population-Based Study, 2000–2018

SIMPLE SUMMARY: Pancreatic cancer (PC) incidence is increasing at a greater rate in young women compared to young men. We aimed to understand the association of race and ethnicity with these trends by performing race, ethnicity and age-specific analysis using the SEER 21 database. We organized race and ethnicity groups by Non-Hispanic White (White), Non-Hispanic Black (Black) and Hispanic, and age groups as older adults (age ≥ 55 years) and younger adults (age < 55 years). We found a greater rate of increase in PC incidence among young women compared to young men among all race and ethnicity groups, although young Hispanic and Black women experienced a disproportionately greater increase. When comparing trends among women from all race and ethnicity groups, young Hispanic women experienced a greater rate of increase in PC incidence compared to young White and Black women. Our study demonstrates the association of race and ethnicity with PC incidence trends and highlights the disproportionate burden of disease on young women of color. ABSTRACT: Background and aims: Pancreatic cancer (PC) incidence is increasing at a greater rate in young women compared to young men. We performed a race- and ethnicity-specific evaluation of incidence trends in subgroups stratified by age and sex to investigate the association of race and ethnicity with these trends. Methods: Age-adjusted PC incidence rates (IR) from the years 2000 to 2018 were obtained from the SEER 21 database. Non-Hispanic White (White), Non-Hispanic Black (Black) and Hispanic patients were included. Age categories included older (ages ≥ 55) and younger (ages < 55) adults. Time-trends were described as annual percentage change (APC) and average APC (AAPC). Results: Younger White [AAPC difference = 0.73, p = 0.01)], Black [AAPC difference = 1.96, p = 0.01)] and Hispanic [AAPC difference = 1.55, p = 0.011)] women experienced a greater rate of increase in IR compared to their counterpart men. Younger Hispanic women experienced a greater rate of increase in IR compared to younger Black women [AAPC difference = −1.28, p = 0.028)] and younger White women [AAPC difference = −1.35, p = 0.011)]. Conclusion: Younger women of all races and ethnicities experienced a greater rate of increase in PC IR compared to their counterpart men; however, younger Hispanic and Black women experienced a disproportionately greater increase. Hispanic women experienced a greater rate of increase in IR compared to younger Black and White women.