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Long COVID Syndrome and Cardiovascular Manifestations: A Systematic Review and Meta-Analysis

(1) Background: Long COVID syndrome is a significant cause of morbidity in COVID-19 patients who remain symptomatic with varied clinical presentations beyond three weeks. Furthermore, the relevance of considering cardiovascular outcomes in post-COVID-19 syndrome is important in the current COVID-19...

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Autores principales: Shrestha, Abhigan Babu, Mehta, Aashna, Pokharel, Pashupati, Mishra, Aakash, Adhikari, Lukash, Shrestha, Sajina, Yadav, Randhir Sagar, Khanal, Surakshya, Sah, Ranjit, Nowrouzi-Kia, Behdin, Padhi, Bijaya Kumar, Chattu, Vijay Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913936/
https://www.ncbi.nlm.nih.gov/pubmed/36766599
http://dx.doi.org/10.3390/diagnostics13030491
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author Shrestha, Abhigan Babu
Mehta, Aashna
Pokharel, Pashupati
Mishra, Aakash
Adhikari, Lukash
Shrestha, Sajina
Yadav, Randhir Sagar
Khanal, Surakshya
Sah, Ranjit
Nowrouzi-Kia, Behdin
Padhi, Bijaya Kumar
Chattu, Vijay Kumar
author_facet Shrestha, Abhigan Babu
Mehta, Aashna
Pokharel, Pashupati
Mishra, Aakash
Adhikari, Lukash
Shrestha, Sajina
Yadav, Randhir Sagar
Khanal, Surakshya
Sah, Ranjit
Nowrouzi-Kia, Behdin
Padhi, Bijaya Kumar
Chattu, Vijay Kumar
author_sort Shrestha, Abhigan Babu
collection PubMed
description (1) Background: Long COVID syndrome is a significant cause of morbidity in COVID-19 patients who remain symptomatic with varied clinical presentations beyond three weeks. Furthermore, the relevance of considering cardiovascular outcomes in post-COVID-19 syndrome is important in the current COVID-19 pandemic; (2) Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed for this systematic review and meta-analysis. Systematic searches were conducted from multiple databases without language restrictions until October 8, 2022, to find studies evaluating cardiovascular outcomes such as arrhythmias, myocardium and pericardium diseases, coronary vessel disease, and thromboembolic disorders in post-COVID cases. The pooled odds ratio (OR), and standard mean difference (SMD) with their corresponding 95% confidence intervals (CI) were computed to find the association; (3) Results: Altogether, seven studies with a total of 8,126,462 (cases: 1,321,305; controls: 6,805,157) participants were included in the meta-analysis. Pooled odds ratios of cardiovascular outcomes were significantly higher in post-COVID cases (OR > 1, p < 0.05) than in controls. However, the mortality (OR: 4.76, p = 0.13), and heart rate variability (SMD: −0.06, p = 0.91) between cases and controls were not statistically significant; (4) Conclusions: Significant cardiovascular sequelae in long COVID syndrome highlight the importance of careful cardiac monitoring of COVID-19 patients in the post-COVID phase to address cardiovascular complications as soon as possible; larger-scale prospective studies are required for accurate estimation.
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spelling pubmed-99139362023-02-11 Long COVID Syndrome and Cardiovascular Manifestations: A Systematic Review and Meta-Analysis Shrestha, Abhigan Babu Mehta, Aashna Pokharel, Pashupati Mishra, Aakash Adhikari, Lukash Shrestha, Sajina Yadav, Randhir Sagar Khanal, Surakshya Sah, Ranjit Nowrouzi-Kia, Behdin Padhi, Bijaya Kumar Chattu, Vijay Kumar Diagnostics (Basel) Article (1) Background: Long COVID syndrome is a significant cause of morbidity in COVID-19 patients who remain symptomatic with varied clinical presentations beyond three weeks. Furthermore, the relevance of considering cardiovascular outcomes in post-COVID-19 syndrome is important in the current COVID-19 pandemic; (2) Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed for this systematic review and meta-analysis. Systematic searches were conducted from multiple databases without language restrictions until October 8, 2022, to find studies evaluating cardiovascular outcomes such as arrhythmias, myocardium and pericardium diseases, coronary vessel disease, and thromboembolic disorders in post-COVID cases. The pooled odds ratio (OR), and standard mean difference (SMD) with their corresponding 95% confidence intervals (CI) were computed to find the association; (3) Results: Altogether, seven studies with a total of 8,126,462 (cases: 1,321,305; controls: 6,805,157) participants were included in the meta-analysis. Pooled odds ratios of cardiovascular outcomes were significantly higher in post-COVID cases (OR > 1, p < 0.05) than in controls. However, the mortality (OR: 4.76, p = 0.13), and heart rate variability (SMD: −0.06, p = 0.91) between cases and controls were not statistically significant; (4) Conclusions: Significant cardiovascular sequelae in long COVID syndrome highlight the importance of careful cardiac monitoring of COVID-19 patients in the post-COVID phase to address cardiovascular complications as soon as possible; larger-scale prospective studies are required for accurate estimation. MDPI 2023-01-29 /pmc/articles/PMC9913936/ /pubmed/36766599 http://dx.doi.org/10.3390/diagnostics13030491 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shrestha, Abhigan Babu
Mehta, Aashna
Pokharel, Pashupati
Mishra, Aakash
Adhikari, Lukash
Shrestha, Sajina
Yadav, Randhir Sagar
Khanal, Surakshya
Sah, Ranjit
Nowrouzi-Kia, Behdin
Padhi, Bijaya Kumar
Chattu, Vijay Kumar
Long COVID Syndrome and Cardiovascular Manifestations: A Systematic Review and Meta-Analysis
title Long COVID Syndrome and Cardiovascular Manifestations: A Systematic Review and Meta-Analysis
title_full Long COVID Syndrome and Cardiovascular Manifestations: A Systematic Review and Meta-Analysis
title_fullStr Long COVID Syndrome and Cardiovascular Manifestations: A Systematic Review and Meta-Analysis
title_full_unstemmed Long COVID Syndrome and Cardiovascular Manifestations: A Systematic Review and Meta-Analysis
title_short Long COVID Syndrome and Cardiovascular Manifestations: A Systematic Review and Meta-Analysis
title_sort long covid syndrome and cardiovascular manifestations: a systematic review and meta-analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9913936/
https://www.ncbi.nlm.nih.gov/pubmed/36766599
http://dx.doi.org/10.3390/diagnostics13030491
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