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Prevalence of HIV and Viral Hepatitis Markers among Healthcare Workers in the Republic of Guinea

Healthcare workers are much more likely to be infected with HIV and hepatitis viruses compared to the general population. Although healthcare workers are more aware of HIV and hepatitis viruses, several countries in Africa lack a comprehensive grasp of disease routes and transmission risks. The aim...

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Autores principales: Ostankova, Yulia V., Shchemelev, Alexander N., Boumbaly, Sanaba, Balde, Thierno A. L., Zueva, Elena B., Valutite, Diana E., Serikova, Elena N., Davydenko, Vladimir S., Skvoroda, Vsevolod V., Vasileva, Daria A., Semenov, Alexander V., Esaulenko, Elena V., Totolian, Areg A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914033/
https://www.ncbi.nlm.nih.gov/pubmed/36766482
http://dx.doi.org/10.3390/diagnostics13030378
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author Ostankova, Yulia V.
Shchemelev, Alexander N.
Boumbaly, Sanaba
Balde, Thierno A. L.
Zueva, Elena B.
Valutite, Diana E.
Serikova, Elena N.
Davydenko, Vladimir S.
Skvoroda, Vsevolod V.
Vasileva, Daria A.
Semenov, Alexander V.
Esaulenko, Elena V.
Totolian, Areg A.
author_facet Ostankova, Yulia V.
Shchemelev, Alexander N.
Boumbaly, Sanaba
Balde, Thierno A. L.
Zueva, Elena B.
Valutite, Diana E.
Serikova, Elena N.
Davydenko, Vladimir S.
Skvoroda, Vsevolod V.
Vasileva, Daria A.
Semenov, Alexander V.
Esaulenko, Elena V.
Totolian, Areg A.
author_sort Ostankova, Yulia V.
collection PubMed
description Healthcare workers are much more likely to be infected with HIV and hepatitis viruses compared to the general population. Although healthcare workers are more aware of HIV and hepatitis viruses, several countries in Africa lack a comprehensive grasp of disease routes and transmission risks. The aim of this study was to assess the prevalence of the serological and molecular biological markers of HIV and viral hepatitis among healthcare workers in the Republic of Guinea. The study material was 74 blood serum samples collected from healthcare workers who received additional training at the Institute of Applied Biological Research of Guinea (IRBAG, Kindia, Republic of Guinea). The markers examined included HBsAg, HBeAg, anti-HBs IgG, anti-HBcore IgG, anti-HCV qualitative determination, anti-HEV IgM and IgG, anti-HAV IgM and IgG, and anti-HIV. For viral DNA and RNA detection, nucleic acids were extracted from blood serum, and viral presence was inferred using real-time PCR with hybridization fluorescence detection. A high prevalence of viral hepatitis B markers was shown, and significantly fewer cases of viral hepatitis C and HIV were detected. Almost all examined medical workers had anti-HAV IgG antibodies, but no antibodies to hepatitis E virus. Apparently, the identified markers depend on the general prevalence of certain pathogens in the region and are associated with the traditions and characteristics of the country’s residents.
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spelling pubmed-99140332023-02-11 Prevalence of HIV and Viral Hepatitis Markers among Healthcare Workers in the Republic of Guinea Ostankova, Yulia V. Shchemelev, Alexander N. Boumbaly, Sanaba Balde, Thierno A. L. Zueva, Elena B. Valutite, Diana E. Serikova, Elena N. Davydenko, Vladimir S. Skvoroda, Vsevolod V. Vasileva, Daria A. Semenov, Alexander V. Esaulenko, Elena V. Totolian, Areg A. Diagnostics (Basel) Article Healthcare workers are much more likely to be infected with HIV and hepatitis viruses compared to the general population. Although healthcare workers are more aware of HIV and hepatitis viruses, several countries in Africa lack a comprehensive grasp of disease routes and transmission risks. The aim of this study was to assess the prevalence of the serological and molecular biological markers of HIV and viral hepatitis among healthcare workers in the Republic of Guinea. The study material was 74 blood serum samples collected from healthcare workers who received additional training at the Institute of Applied Biological Research of Guinea (IRBAG, Kindia, Republic of Guinea). The markers examined included HBsAg, HBeAg, anti-HBs IgG, anti-HBcore IgG, anti-HCV qualitative determination, anti-HEV IgM and IgG, anti-HAV IgM and IgG, and anti-HIV. For viral DNA and RNA detection, nucleic acids were extracted from blood serum, and viral presence was inferred using real-time PCR with hybridization fluorescence detection. A high prevalence of viral hepatitis B markers was shown, and significantly fewer cases of viral hepatitis C and HIV were detected. Almost all examined medical workers had anti-HAV IgG antibodies, but no antibodies to hepatitis E virus. Apparently, the identified markers depend on the general prevalence of certain pathogens in the region and are associated with the traditions and characteristics of the country’s residents. MDPI 2023-01-19 /pmc/articles/PMC9914033/ /pubmed/36766482 http://dx.doi.org/10.3390/diagnostics13030378 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ostankova, Yulia V.
Shchemelev, Alexander N.
Boumbaly, Sanaba
Balde, Thierno A. L.
Zueva, Elena B.
Valutite, Diana E.
Serikova, Elena N.
Davydenko, Vladimir S.
Skvoroda, Vsevolod V.
Vasileva, Daria A.
Semenov, Alexander V.
Esaulenko, Elena V.
Totolian, Areg A.
Prevalence of HIV and Viral Hepatitis Markers among Healthcare Workers in the Republic of Guinea
title Prevalence of HIV and Viral Hepatitis Markers among Healthcare Workers in the Republic of Guinea
title_full Prevalence of HIV and Viral Hepatitis Markers among Healthcare Workers in the Republic of Guinea
title_fullStr Prevalence of HIV and Viral Hepatitis Markers among Healthcare Workers in the Republic of Guinea
title_full_unstemmed Prevalence of HIV and Viral Hepatitis Markers among Healthcare Workers in the Republic of Guinea
title_short Prevalence of HIV and Viral Hepatitis Markers among Healthcare Workers in the Republic of Guinea
title_sort prevalence of hiv and viral hepatitis markers among healthcare workers in the republic of guinea
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914033/
https://www.ncbi.nlm.nih.gov/pubmed/36766482
http://dx.doi.org/10.3390/diagnostics13030378
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