Cargando…

Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management

Introduction: The pathophysiology of preeclampsia is represented by placental ischemia and the release of angiogenic factors. Recent research suggests that using the value of the sFtl-1/PIGF ratio is more accurate for monitoring angiogenic activity. The aim of this study consists in assessing the cl...

Descripción completa

Detalles Bibliográficos
Autores principales: Ciciu, Elena, Paṣatu-Cornea, Ana-Maria, Dumitru, Stefania, Petcu, Lucian Cristian, Salim, Camer, Tuta, Liliana-Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914058/
https://www.ncbi.nlm.nih.gov/pubmed/36766955
http://dx.doi.org/10.3390/healthcare11030381
_version_ 1784885576051195904
author Ciciu, Elena
Paṣatu-Cornea, Ana-Maria
Dumitru, Stefania
Petcu, Lucian Cristian
Salim, Camer
Tuta, Liliana-Ana
author_facet Ciciu, Elena
Paṣatu-Cornea, Ana-Maria
Dumitru, Stefania
Petcu, Lucian Cristian
Salim, Camer
Tuta, Liliana-Ana
author_sort Ciciu, Elena
collection PubMed
description Introduction: The pathophysiology of preeclampsia is represented by placental ischemia and the release of angiogenic factors. Recent research suggests that using the value of the sFtl-1/PIGF ratio is more accurate for monitoring angiogenic activity. The aim of this study consists in assessing the clinical utility of the sFtl-1/PIGF ratio in determining the diagnosis and severity of preeclampsia. Material and Methods: In our study a descriptive and prospective plan was used for analyzing the specific value of the sFtl-1/PIGF ratio in women with preeclampsia and in women with gestational hypertension, depending on the gestational age and severity. Results: The study included 59 women with preeclampsia and 25 women with gestational hypertension. The mean value of the sFtl-1/PIGF ratio of pregnant women with preeclampsia was 209.2 pg/mL, while in the gestational hypertension group, the mean value of the sFtl-1/PIGF ratio was 46.08 pg/mL. The difference between the value of the sFtl-1/PIGF ratio of the group with preeclampsia and the gestational hypertension group was > 67 (pg/mL), with a sensitivity of 86.44% and a specificity of 92.00%. Significant differences were found between the median values of the sFtl-1/PIGF ratio in pregnant women with severe preeclampsia in the early-onset subgroup compared to those in the late-onset subgroup (307 pg/mL, and 98 pg/mL, respectively, p = 0.009 < α = 0.05). Conclusions: The sFtl-1/PIGF ratio may be an alternative method for diagnosing preeclampsia and it can provide data about this condition’s severity.
format Online
Article
Text
id pubmed-9914058
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-99140582023-02-11 Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management Ciciu, Elena Paṣatu-Cornea, Ana-Maria Dumitru, Stefania Petcu, Lucian Cristian Salim, Camer Tuta, Liliana-Ana Healthcare (Basel) Article Introduction: The pathophysiology of preeclampsia is represented by placental ischemia and the release of angiogenic factors. Recent research suggests that using the value of the sFtl-1/PIGF ratio is more accurate for monitoring angiogenic activity. The aim of this study consists in assessing the clinical utility of the sFtl-1/PIGF ratio in determining the diagnosis and severity of preeclampsia. Material and Methods: In our study a descriptive and prospective plan was used for analyzing the specific value of the sFtl-1/PIGF ratio in women with preeclampsia and in women with gestational hypertension, depending on the gestational age and severity. Results: The study included 59 women with preeclampsia and 25 women with gestational hypertension. The mean value of the sFtl-1/PIGF ratio of pregnant women with preeclampsia was 209.2 pg/mL, while in the gestational hypertension group, the mean value of the sFtl-1/PIGF ratio was 46.08 pg/mL. The difference between the value of the sFtl-1/PIGF ratio of the group with preeclampsia and the gestational hypertension group was > 67 (pg/mL), with a sensitivity of 86.44% and a specificity of 92.00%. Significant differences were found between the median values of the sFtl-1/PIGF ratio in pregnant women with severe preeclampsia in the early-onset subgroup compared to those in the late-onset subgroup (307 pg/mL, and 98 pg/mL, respectively, p = 0.009 < α = 0.05). Conclusions: The sFtl-1/PIGF ratio may be an alternative method for diagnosing preeclampsia and it can provide data about this condition’s severity. MDPI 2023-01-29 /pmc/articles/PMC9914058/ /pubmed/36766955 http://dx.doi.org/10.3390/healthcare11030381 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ciciu, Elena
Paṣatu-Cornea, Ana-Maria
Dumitru, Stefania
Petcu, Lucian Cristian
Salim, Camer
Tuta, Liliana-Ana
Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management
title Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management
title_full Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management
title_fullStr Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management
title_full_unstemmed Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management
title_short Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management
title_sort utility of sftl-1 and placental growth factor ratio for adequate preeclampsia management
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914058/
https://www.ncbi.nlm.nih.gov/pubmed/36766955
http://dx.doi.org/10.3390/healthcare11030381
work_keys_str_mv AT ciciuelena utilityofsftl1andplacentalgrowthfactorratioforadequatepreeclampsiamanagement
AT pasatucorneaanamaria utilityofsftl1andplacentalgrowthfactorratioforadequatepreeclampsiamanagement
AT dumitrustefania utilityofsftl1andplacentalgrowthfactorratioforadequatepreeclampsiamanagement
AT petculuciancristian utilityofsftl1andplacentalgrowthfactorratioforadequatepreeclampsiamanagement
AT salimcamer utilityofsftl1andplacentalgrowthfactorratioforadequatepreeclampsiamanagement
AT tutalilianaana utilityofsftl1andplacentalgrowthfactorratioforadequatepreeclampsiamanagement