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Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management
Introduction: The pathophysiology of preeclampsia is represented by placental ischemia and the release of angiogenic factors. Recent research suggests that using the value of the sFtl-1/PIGF ratio is more accurate for monitoring angiogenic activity. The aim of this study consists in assessing the cl...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914058/ https://www.ncbi.nlm.nih.gov/pubmed/36766955 http://dx.doi.org/10.3390/healthcare11030381 |
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author | Ciciu, Elena Paṣatu-Cornea, Ana-Maria Dumitru, Stefania Petcu, Lucian Cristian Salim, Camer Tuta, Liliana-Ana |
author_facet | Ciciu, Elena Paṣatu-Cornea, Ana-Maria Dumitru, Stefania Petcu, Lucian Cristian Salim, Camer Tuta, Liliana-Ana |
author_sort | Ciciu, Elena |
collection | PubMed |
description | Introduction: The pathophysiology of preeclampsia is represented by placental ischemia and the release of angiogenic factors. Recent research suggests that using the value of the sFtl-1/PIGF ratio is more accurate for monitoring angiogenic activity. The aim of this study consists in assessing the clinical utility of the sFtl-1/PIGF ratio in determining the diagnosis and severity of preeclampsia. Material and Methods: In our study a descriptive and prospective plan was used for analyzing the specific value of the sFtl-1/PIGF ratio in women with preeclampsia and in women with gestational hypertension, depending on the gestational age and severity. Results: The study included 59 women with preeclampsia and 25 women with gestational hypertension. The mean value of the sFtl-1/PIGF ratio of pregnant women with preeclampsia was 209.2 pg/mL, while in the gestational hypertension group, the mean value of the sFtl-1/PIGF ratio was 46.08 pg/mL. The difference between the value of the sFtl-1/PIGF ratio of the group with preeclampsia and the gestational hypertension group was > 67 (pg/mL), with a sensitivity of 86.44% and a specificity of 92.00%. Significant differences were found between the median values of the sFtl-1/PIGF ratio in pregnant women with severe preeclampsia in the early-onset subgroup compared to those in the late-onset subgroup (307 pg/mL, and 98 pg/mL, respectively, p = 0.009 < α = 0.05). Conclusions: The sFtl-1/PIGF ratio may be an alternative method for diagnosing preeclampsia and it can provide data about this condition’s severity. |
format | Online Article Text |
id | pubmed-9914058 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99140582023-02-11 Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management Ciciu, Elena Paṣatu-Cornea, Ana-Maria Dumitru, Stefania Petcu, Lucian Cristian Salim, Camer Tuta, Liliana-Ana Healthcare (Basel) Article Introduction: The pathophysiology of preeclampsia is represented by placental ischemia and the release of angiogenic factors. Recent research suggests that using the value of the sFtl-1/PIGF ratio is more accurate for monitoring angiogenic activity. The aim of this study consists in assessing the clinical utility of the sFtl-1/PIGF ratio in determining the diagnosis and severity of preeclampsia. Material and Methods: In our study a descriptive and prospective plan was used for analyzing the specific value of the sFtl-1/PIGF ratio in women with preeclampsia and in women with gestational hypertension, depending on the gestational age and severity. Results: The study included 59 women with preeclampsia and 25 women with gestational hypertension. The mean value of the sFtl-1/PIGF ratio of pregnant women with preeclampsia was 209.2 pg/mL, while in the gestational hypertension group, the mean value of the sFtl-1/PIGF ratio was 46.08 pg/mL. The difference between the value of the sFtl-1/PIGF ratio of the group with preeclampsia and the gestational hypertension group was > 67 (pg/mL), with a sensitivity of 86.44% and a specificity of 92.00%. Significant differences were found between the median values of the sFtl-1/PIGF ratio in pregnant women with severe preeclampsia in the early-onset subgroup compared to those in the late-onset subgroup (307 pg/mL, and 98 pg/mL, respectively, p = 0.009 < α = 0.05). Conclusions: The sFtl-1/PIGF ratio may be an alternative method for diagnosing preeclampsia and it can provide data about this condition’s severity. MDPI 2023-01-29 /pmc/articles/PMC9914058/ /pubmed/36766955 http://dx.doi.org/10.3390/healthcare11030381 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ciciu, Elena Paṣatu-Cornea, Ana-Maria Dumitru, Stefania Petcu, Lucian Cristian Salim, Camer Tuta, Liliana-Ana Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management |
title | Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management |
title_full | Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management |
title_fullStr | Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management |
title_full_unstemmed | Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management |
title_short | Utility of sFtl-1 and Placental Growth Factor Ratio for Adequate Preeclampsia Management |
title_sort | utility of sftl-1 and placental growth factor ratio for adequate preeclampsia management |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914058/ https://www.ncbi.nlm.nih.gov/pubmed/36766955 http://dx.doi.org/10.3390/healthcare11030381 |
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