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Diabetes and Its Cardiovascular Complications: Potential Role of the Acetyltransferase p300

Diabetes has been shown to accelerate vascular senescence, which is associated with chronic inflammation and oxidative stress, both implicated in the development of endothelial dysfunction. This condition represents the initial alteration linking diabetes to related cardiovascular (CV) complications...

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Autores principales: Di Pietrantonio, Nadia, Di Tomo, Pamela, Mandatori, Domitilla, Formoso, Gloria, Pandolfi, Assunta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914144/
https://www.ncbi.nlm.nih.gov/pubmed/36766773
http://dx.doi.org/10.3390/cells12030431
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author Di Pietrantonio, Nadia
Di Tomo, Pamela
Mandatori, Domitilla
Formoso, Gloria
Pandolfi, Assunta
author_facet Di Pietrantonio, Nadia
Di Tomo, Pamela
Mandatori, Domitilla
Formoso, Gloria
Pandolfi, Assunta
author_sort Di Pietrantonio, Nadia
collection PubMed
description Diabetes has been shown to accelerate vascular senescence, which is associated with chronic inflammation and oxidative stress, both implicated in the development of endothelial dysfunction. This condition represents the initial alteration linking diabetes to related cardiovascular (CV) complications. Recently, it has been hypothesised that the acetyltransferase, p300, may contribute to establishing an early vascular senescent phenotype, playing a relevant role in diabetes-associated inflammation and oxidative stress, which drive endothelial dysfunction. Specifically, p300 can modulate vascular inflammation through epigenetic mechanisms and transcription factors acetylation. Indeed, it regulates the inflammatory pathway by interacting with nuclear factor kappa-light-chain-enhancer of activated B cells p65 subunit (NF-κB p65) or by inducing its acetylation, suggesting a crucial role of p300 as a bridge between NF-κB p65 and the transcriptional machinery. Additionally, p300-mediated epigenetic modifications could be upstream of the activation of inflammatory cytokines, and they may induce oxidative stress by affecting the production of reactive oxygen species (ROS). Because several in vitro and in vivo studies shed light on the potential use of acetyltransferase inhibitors, a better understanding of the mechanisms underlying the role of p300 in diabetic vascular dysfunction could help in finding new strategies for the clinical management of CV diseases related to diabetes.
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spelling pubmed-99141442023-02-11 Diabetes and Its Cardiovascular Complications: Potential Role of the Acetyltransferase p300 Di Pietrantonio, Nadia Di Tomo, Pamela Mandatori, Domitilla Formoso, Gloria Pandolfi, Assunta Cells Review Diabetes has been shown to accelerate vascular senescence, which is associated with chronic inflammation and oxidative stress, both implicated in the development of endothelial dysfunction. This condition represents the initial alteration linking diabetes to related cardiovascular (CV) complications. Recently, it has been hypothesised that the acetyltransferase, p300, may contribute to establishing an early vascular senescent phenotype, playing a relevant role in diabetes-associated inflammation and oxidative stress, which drive endothelial dysfunction. Specifically, p300 can modulate vascular inflammation through epigenetic mechanisms and transcription factors acetylation. Indeed, it regulates the inflammatory pathway by interacting with nuclear factor kappa-light-chain-enhancer of activated B cells p65 subunit (NF-κB p65) or by inducing its acetylation, suggesting a crucial role of p300 as a bridge between NF-κB p65 and the transcriptional machinery. Additionally, p300-mediated epigenetic modifications could be upstream of the activation of inflammatory cytokines, and they may induce oxidative stress by affecting the production of reactive oxygen species (ROS). Because several in vitro and in vivo studies shed light on the potential use of acetyltransferase inhibitors, a better understanding of the mechanisms underlying the role of p300 in diabetic vascular dysfunction could help in finding new strategies for the clinical management of CV diseases related to diabetes. MDPI 2023-01-28 /pmc/articles/PMC9914144/ /pubmed/36766773 http://dx.doi.org/10.3390/cells12030431 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Di Pietrantonio, Nadia
Di Tomo, Pamela
Mandatori, Domitilla
Formoso, Gloria
Pandolfi, Assunta
Diabetes and Its Cardiovascular Complications: Potential Role of the Acetyltransferase p300
title Diabetes and Its Cardiovascular Complications: Potential Role of the Acetyltransferase p300
title_full Diabetes and Its Cardiovascular Complications: Potential Role of the Acetyltransferase p300
title_fullStr Diabetes and Its Cardiovascular Complications: Potential Role of the Acetyltransferase p300
title_full_unstemmed Diabetes and Its Cardiovascular Complications: Potential Role of the Acetyltransferase p300
title_short Diabetes and Its Cardiovascular Complications: Potential Role of the Acetyltransferase p300
title_sort diabetes and its cardiovascular complications: potential role of the acetyltransferase p300
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914144/
https://www.ncbi.nlm.nih.gov/pubmed/36766773
http://dx.doi.org/10.3390/cells12030431
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