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Pathways of TB Transmission in Children—A Systematic Review of Molecular Epidemiological Studies

The widespread paradigm that younger children usually do not transmit M. tuberculosis complex (Mtbc) to their contacts has not yet been proven by genotypically confirmed transmissions. Therefore, we undertook a systematic review of molecular-epidemiological studies to investigate documented source a...

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Autores principales: Diel, Roland, Nienhaus, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914148/
https://www.ncbi.nlm.nih.gov/pubmed/36767111
http://dx.doi.org/10.3390/ijerph20031737
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author Diel, Roland
Nienhaus, Albert
author_facet Diel, Roland
Nienhaus, Albert
author_sort Diel, Roland
collection PubMed
description The widespread paradigm that younger children usually do not transmit M. tuberculosis complex (Mtbc) to their contacts has not yet been proven by genotypically confirmed transmissions. Therefore, we undertook a systematic review of molecular-epidemiological studies to investigate documented source and secondary TB (tuberculosis) cases among children. We searched the literature published before August 2022 using PubMed, Cochrane, and Google Scholar databases. PRISMA statement was used for systematic review. Of 312 records retrieved, 39 studies including children aged below 15 years offered epidemiological links between cluster members. In the 39 studies from 16 countries, 225 children were reported as cluster members of whom the overwhelming majority were infected by adults. Only 3 children—of those were 2 children aged below 10—were reported to be the definite source cases of 11 other children and 1 adult with genotypically matched Mtbc isolates. To date, molecular-epidemiological studies involving children with verified transmission links are scarce. As far as the heterogeneity of the studies we identified allows, we could conclude that the results confirm the paradigm that children aged below 10 hardly ever transmit Mtbc to others. The true extent of TB transmission through children may, however, be underestimated by those selected studies.
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spelling pubmed-99141482023-02-11 Pathways of TB Transmission in Children—A Systematic Review of Molecular Epidemiological Studies Diel, Roland Nienhaus, Albert Int J Environ Res Public Health Systematic Review The widespread paradigm that younger children usually do not transmit M. tuberculosis complex (Mtbc) to their contacts has not yet been proven by genotypically confirmed transmissions. Therefore, we undertook a systematic review of molecular-epidemiological studies to investigate documented source and secondary TB (tuberculosis) cases among children. We searched the literature published before August 2022 using PubMed, Cochrane, and Google Scholar databases. PRISMA statement was used for systematic review. Of 312 records retrieved, 39 studies including children aged below 15 years offered epidemiological links between cluster members. In the 39 studies from 16 countries, 225 children were reported as cluster members of whom the overwhelming majority were infected by adults. Only 3 children—of those were 2 children aged below 10—were reported to be the definite source cases of 11 other children and 1 adult with genotypically matched Mtbc isolates. To date, molecular-epidemiological studies involving children with verified transmission links are scarce. As far as the heterogeneity of the studies we identified allows, we could conclude that the results confirm the paradigm that children aged below 10 hardly ever transmit Mtbc to others. The true extent of TB transmission through children may, however, be underestimated by those selected studies. MDPI 2023-01-18 /pmc/articles/PMC9914148/ /pubmed/36767111 http://dx.doi.org/10.3390/ijerph20031737 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Diel, Roland
Nienhaus, Albert
Pathways of TB Transmission in Children—A Systematic Review of Molecular Epidemiological Studies
title Pathways of TB Transmission in Children—A Systematic Review of Molecular Epidemiological Studies
title_full Pathways of TB Transmission in Children—A Systematic Review of Molecular Epidemiological Studies
title_fullStr Pathways of TB Transmission in Children—A Systematic Review of Molecular Epidemiological Studies
title_full_unstemmed Pathways of TB Transmission in Children—A Systematic Review of Molecular Epidemiological Studies
title_short Pathways of TB Transmission in Children—A Systematic Review of Molecular Epidemiological Studies
title_sort pathways of tb transmission in children—a systematic review of molecular epidemiological studies
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914148/
https://www.ncbi.nlm.nih.gov/pubmed/36767111
http://dx.doi.org/10.3390/ijerph20031737
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