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How Frequently Benign Uterine Myomas Appear Suspicious for Sarcoma as Assessed by Transvaginal Ultrasound?

Background: Uterine myomas may resemble uterine sarcomas in some cases. However, the rate of benign myomas appearing as sarcomas at an ultrasound examination is not known. The objective of this study is to determine the percentage of benign myomas that appear suspicious for uterine sarcoma on ultras...

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Autores principales: Cabezas, Nieves, López-Picazo, Ana, Diaz, Patricia, Valero, Beatriz, Rodriguez, María José, Redondo, Ana, Díaz-de la Noval, Begoña, Pascual, Maria Angela, Ajossa, Silvia, Guerriero, Stefano, Alcázar, Juan Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914371/
https://www.ncbi.nlm.nih.gov/pubmed/36766608
http://dx.doi.org/10.3390/diagnostics13030501
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author Cabezas, Nieves
López-Picazo, Ana
Diaz, Patricia
Valero, Beatriz
Rodriguez, María José
Redondo, Ana
Díaz-de la Noval, Begoña
Pascual, Maria Angela
Ajossa, Silvia
Guerriero, Stefano
Alcázar, Juan Luis
author_facet Cabezas, Nieves
López-Picazo, Ana
Diaz, Patricia
Valero, Beatriz
Rodriguez, María José
Redondo, Ana
Díaz-de la Noval, Begoña
Pascual, Maria Angela
Ajossa, Silvia
Guerriero, Stefano
Alcázar, Juan Luis
author_sort Cabezas, Nieves
collection PubMed
description Background: Uterine myomas may resemble uterine sarcomas in some cases. However, the rate of benign myomas appearing as sarcomas at an ultrasound examination is not known. The objective of this study is to determine the percentage of benign myomas that appear suspicious for uterine sarcoma on ultrasound examination. This is a prospective observational multicenter study (June 2019–December 2021) comprising a consecutive series of patients with histologically proven uterine myoma after hysterectomy or myomectomy who underwent transvaginal and/or transabdominal ultrasound prior to surgery. All ultrasound examinations were performed by expert examiners. MUSA criteria were used to describe the lesions (1). Suspicion of sarcoma was established when three or more sonographic features, described by Ludovisi et al. as “frequently seen in uterine sarcoma”, were present (2). These features are no visible myometrium, irregular cystic areas, non-uniform echogenicity, irregular contour, “cooked” appearance, and a Doppler color score of 3–4. In addition, the examiners had to classify the lesion as suspicious based on her/his impression, independent of the number of features present. Eight hundred and ten women were included. The median maximum diameter of the myomas was 58.7 mm (range: 10.0–263.0 mm). Three hundred and forty-nine (43.1%) of the patients had more than one myoma. Using the criterion of >3 suspicious features, 40 (4.9%) of the myomas had suspicious appearance. By subjective impression, the examiners considered 40 (4.9%) cases suspicious. The cases were not exactly the same. We conclude that approximately 5% of benign uterine myomas may exhibit sonographic suspicion of sarcoma. Although it is a small percentage, it is not negligible.
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spelling pubmed-99143712023-02-11 How Frequently Benign Uterine Myomas Appear Suspicious for Sarcoma as Assessed by Transvaginal Ultrasound? Cabezas, Nieves López-Picazo, Ana Diaz, Patricia Valero, Beatriz Rodriguez, María José Redondo, Ana Díaz-de la Noval, Begoña Pascual, Maria Angela Ajossa, Silvia Guerriero, Stefano Alcázar, Juan Luis Diagnostics (Basel) Article Background: Uterine myomas may resemble uterine sarcomas in some cases. However, the rate of benign myomas appearing as sarcomas at an ultrasound examination is not known. The objective of this study is to determine the percentage of benign myomas that appear suspicious for uterine sarcoma on ultrasound examination. This is a prospective observational multicenter study (June 2019–December 2021) comprising a consecutive series of patients with histologically proven uterine myoma after hysterectomy or myomectomy who underwent transvaginal and/or transabdominal ultrasound prior to surgery. All ultrasound examinations were performed by expert examiners. MUSA criteria were used to describe the lesions (1). Suspicion of sarcoma was established when three or more sonographic features, described by Ludovisi et al. as “frequently seen in uterine sarcoma”, were present (2). These features are no visible myometrium, irregular cystic areas, non-uniform echogenicity, irregular contour, “cooked” appearance, and a Doppler color score of 3–4. In addition, the examiners had to classify the lesion as suspicious based on her/his impression, independent of the number of features present. Eight hundred and ten women were included. The median maximum diameter of the myomas was 58.7 mm (range: 10.0–263.0 mm). Three hundred and forty-nine (43.1%) of the patients had more than one myoma. Using the criterion of >3 suspicious features, 40 (4.9%) of the myomas had suspicious appearance. By subjective impression, the examiners considered 40 (4.9%) cases suspicious. The cases were not exactly the same. We conclude that approximately 5% of benign uterine myomas may exhibit sonographic suspicion of sarcoma. Although it is a small percentage, it is not negligible. MDPI 2023-01-30 /pmc/articles/PMC9914371/ /pubmed/36766608 http://dx.doi.org/10.3390/diagnostics13030501 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cabezas, Nieves
López-Picazo, Ana
Diaz, Patricia
Valero, Beatriz
Rodriguez, María José
Redondo, Ana
Díaz-de la Noval, Begoña
Pascual, Maria Angela
Ajossa, Silvia
Guerriero, Stefano
Alcázar, Juan Luis
How Frequently Benign Uterine Myomas Appear Suspicious for Sarcoma as Assessed by Transvaginal Ultrasound?
title How Frequently Benign Uterine Myomas Appear Suspicious for Sarcoma as Assessed by Transvaginal Ultrasound?
title_full How Frequently Benign Uterine Myomas Appear Suspicious for Sarcoma as Assessed by Transvaginal Ultrasound?
title_fullStr How Frequently Benign Uterine Myomas Appear Suspicious for Sarcoma as Assessed by Transvaginal Ultrasound?
title_full_unstemmed How Frequently Benign Uterine Myomas Appear Suspicious for Sarcoma as Assessed by Transvaginal Ultrasound?
title_short How Frequently Benign Uterine Myomas Appear Suspicious for Sarcoma as Assessed by Transvaginal Ultrasound?
title_sort how frequently benign uterine myomas appear suspicious for sarcoma as assessed by transvaginal ultrasound?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914371/
https://www.ncbi.nlm.nih.gov/pubmed/36766608
http://dx.doi.org/10.3390/diagnostics13030501
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