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Omicron in Infants—Respiratory or Digestive Disease?
The Omicron variant of SARS-CoV-2 has caused a large number of cases and hospitalizations in the pediatric population. Infants due to their age are susceptible to viral infections that may have a worse prognosis. Therefore, the aim of the current study has been to characterize the clinical features...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914388/ https://www.ncbi.nlm.nih.gov/pubmed/36766525 http://dx.doi.org/10.3390/diagnostics13030421 |
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author | Drăgănescu, Anca Cristina Miron, Victor Daniel Săndulescu, Oana Bilaşco, Anuţa Streinu-Cercel, Anca Sandu, Roxana Gabriela Marinescu, Adrian Gunșahin, Deniz Hoffmann, Karina Ioana Horobeț, Daria Ștefana Pițigoi, Daniela Streinu-Cercel, Adrian Pleșca, Doina Anca |
author_facet | Drăgănescu, Anca Cristina Miron, Victor Daniel Săndulescu, Oana Bilaşco, Anuţa Streinu-Cercel, Anca Sandu, Roxana Gabriela Marinescu, Adrian Gunșahin, Deniz Hoffmann, Karina Ioana Horobeț, Daria Ștefana Pițigoi, Daniela Streinu-Cercel, Adrian Pleșca, Doina Anca |
author_sort | Drăgănescu, Anca Cristina |
collection | PubMed |
description | The Omicron variant of SARS-CoV-2 has caused a large number of cases and hospitalizations in the pediatric population. Infants due to their age are susceptible to viral infections that may have a worse prognosis. Therefore, the aim of the current study has been to characterize the clinical features and the outcome of infants hospitalized with confirmed SARS-CoV-2 infection during the Omicron wave. We conducted a retrospective study of all consecutive infants hospitalized with symptomatic COVID-19 and no other co-infections, from January to September 2022 in one of the largest infectious diseases hospitals from Bucharest, Romania. A total of 613 infants were included in the analysis. The median age was 5 months (IQR: 3, 8 months). The clinical features were dominated by fever (96.4%), cough (64.8%) and loss of appetite (63.3%), and overall, respiratory symptoms were the most numerous (76.0%). Infants between 1-3 months old had a 1.5-fold increased risk of elevated alanine aminotransferase (ALT) values, and a longer length of hospitalization as compared to older infants. Infants between 7-9 months of age had 1.5-fold higher odds of loss of appetite, 1.7-fold more frequent cough and 1.6-fold more frequent digestive symptoms compared to infants in other age groups. The presence of digestive symptoms increased the probability of hepatic cytolysis (increased ALT) by 1.9-fold. Continued monitoring of COVID-19 among infants is very necessary, given the progressive character of SARS-CoV-2, in order to take correct and rapid therapeutic measures and to adapt to clinical changes driven by viral variant change. |
format | Online Article Text |
id | pubmed-9914388 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99143882023-02-11 Omicron in Infants—Respiratory or Digestive Disease? Drăgănescu, Anca Cristina Miron, Victor Daniel Săndulescu, Oana Bilaşco, Anuţa Streinu-Cercel, Anca Sandu, Roxana Gabriela Marinescu, Adrian Gunșahin, Deniz Hoffmann, Karina Ioana Horobeț, Daria Ștefana Pițigoi, Daniela Streinu-Cercel, Adrian Pleșca, Doina Anca Diagnostics (Basel) Article The Omicron variant of SARS-CoV-2 has caused a large number of cases and hospitalizations in the pediatric population. Infants due to their age are susceptible to viral infections that may have a worse prognosis. Therefore, the aim of the current study has been to characterize the clinical features and the outcome of infants hospitalized with confirmed SARS-CoV-2 infection during the Omicron wave. We conducted a retrospective study of all consecutive infants hospitalized with symptomatic COVID-19 and no other co-infections, from January to September 2022 in one of the largest infectious diseases hospitals from Bucharest, Romania. A total of 613 infants were included in the analysis. The median age was 5 months (IQR: 3, 8 months). The clinical features were dominated by fever (96.4%), cough (64.8%) and loss of appetite (63.3%), and overall, respiratory symptoms were the most numerous (76.0%). Infants between 1-3 months old had a 1.5-fold increased risk of elevated alanine aminotransferase (ALT) values, and a longer length of hospitalization as compared to older infants. Infants between 7-9 months of age had 1.5-fold higher odds of loss of appetite, 1.7-fold more frequent cough and 1.6-fold more frequent digestive symptoms compared to infants in other age groups. The presence of digestive symptoms increased the probability of hepatic cytolysis (increased ALT) by 1.9-fold. Continued monitoring of COVID-19 among infants is very necessary, given the progressive character of SARS-CoV-2, in order to take correct and rapid therapeutic measures and to adapt to clinical changes driven by viral variant change. MDPI 2023-01-23 /pmc/articles/PMC9914388/ /pubmed/36766525 http://dx.doi.org/10.3390/diagnostics13030421 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Drăgănescu, Anca Cristina Miron, Victor Daniel Săndulescu, Oana Bilaşco, Anuţa Streinu-Cercel, Anca Sandu, Roxana Gabriela Marinescu, Adrian Gunșahin, Deniz Hoffmann, Karina Ioana Horobeț, Daria Ștefana Pițigoi, Daniela Streinu-Cercel, Adrian Pleșca, Doina Anca Omicron in Infants—Respiratory or Digestive Disease? |
title | Omicron in Infants—Respiratory or Digestive Disease? |
title_full | Omicron in Infants—Respiratory or Digestive Disease? |
title_fullStr | Omicron in Infants—Respiratory or Digestive Disease? |
title_full_unstemmed | Omicron in Infants—Respiratory or Digestive Disease? |
title_short | Omicron in Infants—Respiratory or Digestive Disease? |
title_sort | omicron in infants—respiratory or digestive disease? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914388/ https://www.ncbi.nlm.nih.gov/pubmed/36766525 http://dx.doi.org/10.3390/diagnostics13030421 |
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