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Omicron in Infants—Respiratory or Digestive Disease?

The Omicron variant of SARS-CoV-2 has caused a large number of cases and hospitalizations in the pediatric population. Infants due to their age are susceptible to viral infections that may have a worse prognosis. Therefore, the aim of the current study has been to characterize the clinical features...

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Autores principales: Drăgănescu, Anca Cristina, Miron, Victor Daniel, Săndulescu, Oana, Bilaşco, Anuţa, Streinu-Cercel, Anca, Sandu, Roxana Gabriela, Marinescu, Adrian, Gunșahin, Deniz, Hoffmann, Karina Ioana, Horobeț, Daria Ștefana, Pițigoi, Daniela, Streinu-Cercel, Adrian, Pleșca, Doina Anca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914388/
https://www.ncbi.nlm.nih.gov/pubmed/36766525
http://dx.doi.org/10.3390/diagnostics13030421
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author Drăgănescu, Anca Cristina
Miron, Victor Daniel
Săndulescu, Oana
Bilaşco, Anuţa
Streinu-Cercel, Anca
Sandu, Roxana Gabriela
Marinescu, Adrian
Gunșahin, Deniz
Hoffmann, Karina Ioana
Horobeț, Daria Ștefana
Pițigoi, Daniela
Streinu-Cercel, Adrian
Pleșca, Doina Anca
author_facet Drăgănescu, Anca Cristina
Miron, Victor Daniel
Săndulescu, Oana
Bilaşco, Anuţa
Streinu-Cercel, Anca
Sandu, Roxana Gabriela
Marinescu, Adrian
Gunșahin, Deniz
Hoffmann, Karina Ioana
Horobeț, Daria Ștefana
Pițigoi, Daniela
Streinu-Cercel, Adrian
Pleșca, Doina Anca
author_sort Drăgănescu, Anca Cristina
collection PubMed
description The Omicron variant of SARS-CoV-2 has caused a large number of cases and hospitalizations in the pediatric population. Infants due to their age are susceptible to viral infections that may have a worse prognosis. Therefore, the aim of the current study has been to characterize the clinical features and the outcome of infants hospitalized with confirmed SARS-CoV-2 infection during the Omicron wave. We conducted a retrospective study of all consecutive infants hospitalized with symptomatic COVID-19 and no other co-infections, from January to September 2022 in one of the largest infectious diseases hospitals from Bucharest, Romania. A total of 613 infants were included in the analysis. The median age was 5 months (IQR: 3, 8 months). The clinical features were dominated by fever (96.4%), cough (64.8%) and loss of appetite (63.3%), and overall, respiratory symptoms were the most numerous (76.0%). Infants between 1-3 months old had a 1.5-fold increased risk of elevated alanine aminotransferase (ALT) values, and a longer length of hospitalization as compared to older infants. Infants between 7-9 months of age had 1.5-fold higher odds of loss of appetite, 1.7-fold more frequent cough and 1.6-fold more frequent digestive symptoms compared to infants in other age groups. The presence of digestive symptoms increased the probability of hepatic cytolysis (increased ALT) by 1.9-fold. Continued monitoring of COVID-19 among infants is very necessary, given the progressive character of SARS-CoV-2, in order to take correct and rapid therapeutic measures and to adapt to clinical changes driven by viral variant change.
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spelling pubmed-99143882023-02-11 Omicron in Infants—Respiratory or Digestive Disease? Drăgănescu, Anca Cristina Miron, Victor Daniel Săndulescu, Oana Bilaşco, Anuţa Streinu-Cercel, Anca Sandu, Roxana Gabriela Marinescu, Adrian Gunșahin, Deniz Hoffmann, Karina Ioana Horobeț, Daria Ștefana Pițigoi, Daniela Streinu-Cercel, Adrian Pleșca, Doina Anca Diagnostics (Basel) Article The Omicron variant of SARS-CoV-2 has caused a large number of cases and hospitalizations in the pediatric population. Infants due to their age are susceptible to viral infections that may have a worse prognosis. Therefore, the aim of the current study has been to characterize the clinical features and the outcome of infants hospitalized with confirmed SARS-CoV-2 infection during the Omicron wave. We conducted a retrospective study of all consecutive infants hospitalized with symptomatic COVID-19 and no other co-infections, from January to September 2022 in one of the largest infectious diseases hospitals from Bucharest, Romania. A total of 613 infants were included in the analysis. The median age was 5 months (IQR: 3, 8 months). The clinical features were dominated by fever (96.4%), cough (64.8%) and loss of appetite (63.3%), and overall, respiratory symptoms were the most numerous (76.0%). Infants between 1-3 months old had a 1.5-fold increased risk of elevated alanine aminotransferase (ALT) values, and a longer length of hospitalization as compared to older infants. Infants between 7-9 months of age had 1.5-fold higher odds of loss of appetite, 1.7-fold more frequent cough and 1.6-fold more frequent digestive symptoms compared to infants in other age groups. The presence of digestive symptoms increased the probability of hepatic cytolysis (increased ALT) by 1.9-fold. Continued monitoring of COVID-19 among infants is very necessary, given the progressive character of SARS-CoV-2, in order to take correct and rapid therapeutic measures and to adapt to clinical changes driven by viral variant change. MDPI 2023-01-23 /pmc/articles/PMC9914388/ /pubmed/36766525 http://dx.doi.org/10.3390/diagnostics13030421 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Drăgănescu, Anca Cristina
Miron, Victor Daniel
Săndulescu, Oana
Bilaşco, Anuţa
Streinu-Cercel, Anca
Sandu, Roxana Gabriela
Marinescu, Adrian
Gunșahin, Deniz
Hoffmann, Karina Ioana
Horobeț, Daria Ștefana
Pițigoi, Daniela
Streinu-Cercel, Adrian
Pleșca, Doina Anca
Omicron in Infants—Respiratory or Digestive Disease?
title Omicron in Infants—Respiratory or Digestive Disease?
title_full Omicron in Infants—Respiratory or Digestive Disease?
title_fullStr Omicron in Infants—Respiratory or Digestive Disease?
title_full_unstemmed Omicron in Infants—Respiratory or Digestive Disease?
title_short Omicron in Infants—Respiratory or Digestive Disease?
title_sort omicron in infants—respiratory or digestive disease?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914388/
https://www.ncbi.nlm.nih.gov/pubmed/36766525
http://dx.doi.org/10.3390/diagnostics13030421
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