Lateral Diffusion of NKCC1 Contributes to Chloride Homeostasis in Neurons and Is Rapidly Regulated by the WNK Signaling Pathway

An upregulation of the Na(+)-K(+)-2Cl(−) cotransporter NKCC1, the main chloride importer in mature neurons, can lead to depolarizing/excitatory responses mediated by GABA type A receptors (GABA(A)Rs) and, thus, to hyperactivity. Understanding the regulatory mechanisms of NKCC1 would help prevent int...

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Detalles Bibliográficos
Autores principales: Côme, Etienne, Blachier, Simon, Gouhier, Juliette, Russeau, Marion, Lévi, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914440/
https://www.ncbi.nlm.nih.gov/pubmed/36766805
http://dx.doi.org/10.3390/cells12030464

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914440/
https://www.ncbi.nlm.nih.gov/pubmed/36766805
http://dx.doi.org/10.3390/cells12030464

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