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Lateral Diffusion of NKCC1 Contributes to Chloride Homeostasis in Neurons and Is Rapidly Regulated by the WNK Signaling Pathway
An upregulation of the Na(+)-K(+)-2Cl(−) cotransporter NKCC1, the main chloride importer in mature neurons, can lead to depolarizing/excitatory responses mediated by GABA type A receptors (GABA(A)Rs) and, thus, to hyperactivity. Understanding the regulatory mechanisms of NKCC1 would help prevent int...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914440/ https://www.ncbi.nlm.nih.gov/pubmed/36766805 http://dx.doi.org/10.3390/cells12030464 |