Medawar and the immunological paradox of pregnancy: in context

In 1953, Peter Medawar defined ‘the immunological paradox of pregnancy’, whereby the semi-allogeneic foetus can survive for 9 months in its mother, while a semi-allogeneic graft would be rejected. Here, I revisit the immunological paradox of pregnancy, setting it in the context of the time in which...

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Detalles Bibliográficos
Autor principal: Male, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914476/
https://www.ncbi.nlm.nih.gov/pubmed/36845570
http://dx.doi.org/10.1093/oxfimm/iqaa006
Descripción
Sumario:In 1953, Peter Medawar defined ‘the immunological paradox of pregnancy’, whereby the semi-allogeneic foetus can survive for 9 months in its mother, while a semi-allogeneic graft would be rejected. Here, I revisit the immunological paradox of pregnancy, setting it in the context of the time in which it was proposed. I go on to examine the extent to which Medawar’s ideas on the subject have stood the test of time and how they have shaped reproductive immunology.

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