Medawar and the immunological paradox of pregnancy: in context

In 1953, Peter Medawar defined ‘the immunological paradox of pregnancy’, whereby the semi-allogeneic foetus can survive for 9 months in its mother, while a semi-allogeneic graft would be rejected. Here, I revisit the immunological paradox of pregnancy, setting it in the context of the time in which...

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Detalles Bibliográficos
Autor principal: Male, Victoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914476/
https://www.ncbi.nlm.nih.gov/pubmed/36845570
http://dx.doi.org/10.1093/oxfimm/iqaa006
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author Male, Victoria
author_facet Male, Victoria
author_sort Male, Victoria
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description In 1953, Peter Medawar defined ‘the immunological paradox of pregnancy’, whereby the semi-allogeneic foetus can survive for 9 months in its mother, while a semi-allogeneic graft would be rejected. Here, I revisit the immunological paradox of pregnancy, setting it in the context of the time in which it was proposed. I go on to examine the extent to which Medawar’s ideas on the subject have stood the test of time and how they have shaped reproductive immunology.
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spelling pubmed-99144762023-02-24 Medawar and the immunological paradox of pregnancy: in context Male, Victoria Oxf Open Immunol Short Communication In 1953, Peter Medawar defined ‘the immunological paradox of pregnancy’, whereby the semi-allogeneic foetus can survive for 9 months in its mother, while a semi-allogeneic graft would be rejected. Here, I revisit the immunological paradox of pregnancy, setting it in the context of the time in which it was proposed. I go on to examine the extent to which Medawar’s ideas on the subject have stood the test of time and how they have shaped reproductive immunology. Oxford University Press 2020-12-14 /pmc/articles/PMC9914476/ /pubmed/36845570 http://dx.doi.org/10.1093/oxfimm/iqaa006 Text en © The Author(s) 2020. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Male, Victoria
Medawar and the immunological paradox of pregnancy: in context
title Medawar and the immunological paradox of pregnancy: in context
title_full Medawar and the immunological paradox of pregnancy: in context
title_fullStr Medawar and the immunological paradox of pregnancy: in context
title_full_unstemmed Medawar and the immunological paradox of pregnancy: in context
title_short Medawar and the immunological paradox of pregnancy: in context
title_sort medawar and the immunological paradox of pregnancy: in context
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914476/
https://www.ncbi.nlm.nih.gov/pubmed/36845570
http://dx.doi.org/10.1093/oxfimm/iqaa006
work_keys_str_mv AT malevictoria medawarandtheimmunologicalparadoxofpregnancyincontext

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