Pharmacological Targeting of the RAGE-NFκB Signalling Axis Impedes Monocyte Activation under Diabetic Conditions through the Repression of SHP-2 Tyrosine Phosphatase Function

Monocytes play a vital role in the development of cardiovascular diseases. Type 2 diabetes mellitus (T2DM) is a major CVD risk factor, and T2DM-induced aberrant activation and enhanced migration of monocytes is a vital pathomechanism that leads to atherogenesis. We recently reported the upregulation...

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Detalles Bibliográficos
Autores principales: Dorenkamp, Marc, Nasiry, Madina, Semo, Dilvin, Koch, Sybille, Löffler, Ivonne, Wolf, Gunter, Reinecke, Holger, Godfrey, Rinesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914555/
https://www.ncbi.nlm.nih.gov/pubmed/36766855
http://dx.doi.org/10.3390/cells12030513

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