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The Role of mpMRI in the Assessment of Prostate Cancer Recurrence Using the PI-RR System: Diagnostic Accuracy and Interobserver Agreement in Readers with Different Expertise

Background: treated prostate cancer (PCa) patients develop biochemical recurrence (BCR) in 27–53% of cases; the role of MRI in this setting is still controversial. In 2021 a panel of experts proposed a “Prostate Imaging-Recurrence Reporting” (PI-RR) score, aiming to standardize the reporting. The ai...

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Autores principales: Bergaglio, Chiara, Giasotto, Veronica, Marcenaro, Michela, Barra, Salvina, Turazzi, Marianna, Bauckneht, Matteo, Casaleggio, Alessandro, Sciabà, Francesca, Terrone, Carlo, Mantica, Guglielmo, Borghesi, Marco, Signori, Alessio, Spina, Bruno, Piol, Nataniele, Zanardi, Elisa, Fornarini, Giuseppe, Zawaideh, Jeries Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914595/
https://www.ncbi.nlm.nih.gov/pubmed/36766492
http://dx.doi.org/10.3390/diagnostics13030387
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author Bergaglio, Chiara
Giasotto, Veronica
Marcenaro, Michela
Barra, Salvina
Turazzi, Marianna
Bauckneht, Matteo
Casaleggio, Alessandro
Sciabà, Francesca
Terrone, Carlo
Mantica, Guglielmo
Borghesi, Marco
Signori, Alessio
Spina, Bruno
Piol, Nataniele
Zanardi, Elisa
Fornarini, Giuseppe
Zawaideh, Jeries Paolo
author_facet Bergaglio, Chiara
Giasotto, Veronica
Marcenaro, Michela
Barra, Salvina
Turazzi, Marianna
Bauckneht, Matteo
Casaleggio, Alessandro
Sciabà, Francesca
Terrone, Carlo
Mantica, Guglielmo
Borghesi, Marco
Signori, Alessio
Spina, Bruno
Piol, Nataniele
Zanardi, Elisa
Fornarini, Giuseppe
Zawaideh, Jeries Paolo
author_sort Bergaglio, Chiara
collection PubMed
description Background: treated prostate cancer (PCa) patients develop biochemical recurrence (BCR) in 27–53% of cases; the role of MRI in this setting is still controversial. In 2021 a panel of experts proposed a “Prostate Imaging-Recurrence Reporting” (PI-RR) score, aiming to standardize the reporting. The aim of our study is to evaluate the reproducibility of the PI-RR scoring system among readers with different expertise. Methods: in this monocentric, retrospective observational study, the images of patients who underwent MRI with BCR from January 2017 to January 2022 were analyzed by two radiologists and a radiology resident. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were obtained. Interobserver agreement was calculated. The percentage of the PI-RR score of 3 was estimated to find out the proportion of uncertain exams reported among the readers. Results: a total of seventy-six patients were included in our study: eight previously treated with RT and sixty-eight who underwent surgery. The accuracy range was 75–80%, the sensitivity 68.4–71.1%, the specificity 81.6–89.5%, PPV 78.8–87.1%, and NPV 72.1–75.6%. The inter-reader agreement using a binary evaluation (PI-RR ≥ 3 as positive mpMRI) demonstrated a correlation coefficient (k) of 0.74 (95% CI: 0.62–0.87). The percentage for the PI-RR score of 3 was 6.6% for reader one, 14.5% for reader two, and 2.6% for reader three. Conclusion: this study confirmed the good accuracy of mpMRI in the detection of local recurrence of PCa and the good reproducibility of PI-RR score among all readers, confirming it to be a promising tool for the standardization of the assessment of patients with BCR.
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spelling pubmed-99145952023-02-11 The Role of mpMRI in the Assessment of Prostate Cancer Recurrence Using the PI-RR System: Diagnostic Accuracy and Interobserver Agreement in Readers with Different Expertise Bergaglio, Chiara Giasotto, Veronica Marcenaro, Michela Barra, Salvina Turazzi, Marianna Bauckneht, Matteo Casaleggio, Alessandro Sciabà, Francesca Terrone, Carlo Mantica, Guglielmo Borghesi, Marco Signori, Alessio Spina, Bruno Piol, Nataniele Zanardi, Elisa Fornarini, Giuseppe Zawaideh, Jeries Paolo Diagnostics (Basel) Article Background: treated prostate cancer (PCa) patients develop biochemical recurrence (BCR) in 27–53% of cases; the role of MRI in this setting is still controversial. In 2021 a panel of experts proposed a “Prostate Imaging-Recurrence Reporting” (PI-RR) score, aiming to standardize the reporting. The aim of our study is to evaluate the reproducibility of the PI-RR scoring system among readers with different expertise. Methods: in this monocentric, retrospective observational study, the images of patients who underwent MRI with BCR from January 2017 to January 2022 were analyzed by two radiologists and a radiology resident. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were obtained. Interobserver agreement was calculated. The percentage of the PI-RR score of 3 was estimated to find out the proportion of uncertain exams reported among the readers. Results: a total of seventy-six patients were included in our study: eight previously treated with RT and sixty-eight who underwent surgery. The accuracy range was 75–80%, the sensitivity 68.4–71.1%, the specificity 81.6–89.5%, PPV 78.8–87.1%, and NPV 72.1–75.6%. The inter-reader agreement using a binary evaluation (PI-RR ≥ 3 as positive mpMRI) demonstrated a correlation coefficient (k) of 0.74 (95% CI: 0.62–0.87). The percentage for the PI-RR score of 3 was 6.6% for reader one, 14.5% for reader two, and 2.6% for reader three. Conclusion: this study confirmed the good accuracy of mpMRI in the detection of local recurrence of PCa and the good reproducibility of PI-RR score among all readers, confirming it to be a promising tool for the standardization of the assessment of patients with BCR. MDPI 2023-01-20 /pmc/articles/PMC9914595/ /pubmed/36766492 http://dx.doi.org/10.3390/diagnostics13030387 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bergaglio, Chiara
Giasotto, Veronica
Marcenaro, Michela
Barra, Salvina
Turazzi, Marianna
Bauckneht, Matteo
Casaleggio, Alessandro
Sciabà, Francesca
Terrone, Carlo
Mantica, Guglielmo
Borghesi, Marco
Signori, Alessio
Spina, Bruno
Piol, Nataniele
Zanardi, Elisa
Fornarini, Giuseppe
Zawaideh, Jeries Paolo
The Role of mpMRI in the Assessment of Prostate Cancer Recurrence Using the PI-RR System: Diagnostic Accuracy and Interobserver Agreement in Readers with Different Expertise
title The Role of mpMRI in the Assessment of Prostate Cancer Recurrence Using the PI-RR System: Diagnostic Accuracy and Interobserver Agreement in Readers with Different Expertise
title_full The Role of mpMRI in the Assessment of Prostate Cancer Recurrence Using the PI-RR System: Diagnostic Accuracy and Interobserver Agreement in Readers with Different Expertise
title_fullStr The Role of mpMRI in the Assessment of Prostate Cancer Recurrence Using the PI-RR System: Diagnostic Accuracy and Interobserver Agreement in Readers with Different Expertise
title_full_unstemmed The Role of mpMRI in the Assessment of Prostate Cancer Recurrence Using the PI-RR System: Diagnostic Accuracy and Interobserver Agreement in Readers with Different Expertise
title_short The Role of mpMRI in the Assessment of Prostate Cancer Recurrence Using the PI-RR System: Diagnostic Accuracy and Interobserver Agreement in Readers with Different Expertise
title_sort role of mpmri in the assessment of prostate cancer recurrence using the pi-rr system: diagnostic accuracy and interobserver agreement in readers with different expertise
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914595/
https://www.ncbi.nlm.nih.gov/pubmed/36766492
http://dx.doi.org/10.3390/diagnostics13030387
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