Cargando…
Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas
Line-field confocal optical coherence tomography (LC-OCT) is a new, noninvasive imaging technique for the diagnosis of skin cancers. A total of 243 benign (54%) and malignant (46%) skin lesions were consecutively enrolled from 27 August 2020, to 6 October 2021 at the Dermatology Department of the Un...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914674/ https://www.ncbi.nlm.nih.gov/pubmed/36766466 http://dx.doi.org/10.3390/diagnostics13030361 |
_version_ | 1784885721744539648 |
---|---|
author | Cinotti, Elisa Brunetti, Tullio Cartocci, Alessandra Tognetti, Linda Suppa, Mariano Malvehy, Josep Perez-Anker, Javiera Puig, Susanna Perrot, Jean Luc Rubegni, Pietro |
author_facet | Cinotti, Elisa Brunetti, Tullio Cartocci, Alessandra Tognetti, Linda Suppa, Mariano Malvehy, Josep Perez-Anker, Javiera Puig, Susanna Perrot, Jean Luc Rubegni, Pietro |
author_sort | Cinotti, Elisa |
collection | PubMed |
description | Line-field confocal optical coherence tomography (LC-OCT) is a new, noninvasive imaging technique for the diagnosis of skin cancers. A total of 243 benign (54%) and malignant (46%) skin lesions were consecutively enrolled from 27 August 2020, to 6 October 2021 at the Dermatology Department of the University Hospital of Siena, Italy. Dermoscopic- and LC-OCT-based diagnoses were given by an expert dermatologist and compared with the ground truth. Considering all types of malignant skin tumours (79 basal cell carcinomas (BCCs), 22 squamous cell carcinomas, and 10 melanomas), a statistically significant increase (p = 0.013) in specificity was observed from dermoscopy (0.73, CI 0.64–0.81) to LC-OCT (0.87, CI 0.79–0.93) while sensitivity was the same with the two imaging techniques (0.95 CI 0.89–0.98 for dermoscopy and 0.95 CI 0.90–0.99 for LC-OCT). The increase in specificity was mainly driven by the ability of LC-OCT to differentiate BCCs from other diagnoses. In conclusion, our real-life study showed that LC-OCT can play an important role in helping the noninvasive diagnosis of malignant skin neoplasms and especially of BCCs. LC-OCT could be positioned after the dermoscopic examination, to spare useless biopsy of benign lesions without decreasing sensitivity. |
format | Online Article Text |
id | pubmed-9914674 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-99146742023-02-11 Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas Cinotti, Elisa Brunetti, Tullio Cartocci, Alessandra Tognetti, Linda Suppa, Mariano Malvehy, Josep Perez-Anker, Javiera Puig, Susanna Perrot, Jean Luc Rubegni, Pietro Diagnostics (Basel) Article Line-field confocal optical coherence tomography (LC-OCT) is a new, noninvasive imaging technique for the diagnosis of skin cancers. A total of 243 benign (54%) and malignant (46%) skin lesions were consecutively enrolled from 27 August 2020, to 6 October 2021 at the Dermatology Department of the University Hospital of Siena, Italy. Dermoscopic- and LC-OCT-based diagnoses were given by an expert dermatologist and compared with the ground truth. Considering all types of malignant skin tumours (79 basal cell carcinomas (BCCs), 22 squamous cell carcinomas, and 10 melanomas), a statistically significant increase (p = 0.013) in specificity was observed from dermoscopy (0.73, CI 0.64–0.81) to LC-OCT (0.87, CI 0.79–0.93) while sensitivity was the same with the two imaging techniques (0.95 CI 0.89–0.98 for dermoscopy and 0.95 CI 0.90–0.99 for LC-OCT). The increase in specificity was mainly driven by the ability of LC-OCT to differentiate BCCs from other diagnoses. In conclusion, our real-life study showed that LC-OCT can play an important role in helping the noninvasive diagnosis of malignant skin neoplasms and especially of BCCs. LC-OCT could be positioned after the dermoscopic examination, to spare useless biopsy of benign lesions without decreasing sensitivity. MDPI 2023-01-18 /pmc/articles/PMC9914674/ /pubmed/36766466 http://dx.doi.org/10.3390/diagnostics13030361 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Cinotti, Elisa Brunetti, Tullio Cartocci, Alessandra Tognetti, Linda Suppa, Mariano Malvehy, Josep Perez-Anker, Javiera Puig, Susanna Perrot, Jean Luc Rubegni, Pietro Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas |
title | Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas |
title_full | Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas |
title_fullStr | Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas |
title_full_unstemmed | Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas |
title_short | Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas |
title_sort | diagnostic accuracy of line-field confocal optical coherence tomography for the diagnosis of skin carcinomas |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914674/ https://www.ncbi.nlm.nih.gov/pubmed/36766466 http://dx.doi.org/10.3390/diagnostics13030361 |
work_keys_str_mv | AT cinottielisa diagnosticaccuracyoflinefieldconfocalopticalcoherencetomographyforthediagnosisofskincarcinomas AT brunettitullio diagnosticaccuracyoflinefieldconfocalopticalcoherencetomographyforthediagnosisofskincarcinomas AT cartoccialessandra diagnosticaccuracyoflinefieldconfocalopticalcoherencetomographyforthediagnosisofskincarcinomas AT tognettilinda diagnosticaccuracyoflinefieldconfocalopticalcoherencetomographyforthediagnosisofskincarcinomas AT suppamariano diagnosticaccuracyoflinefieldconfocalopticalcoherencetomographyforthediagnosisofskincarcinomas AT malvehyjosep diagnosticaccuracyoflinefieldconfocalopticalcoherencetomographyforthediagnosisofskincarcinomas AT perezankerjaviera diagnosticaccuracyoflinefieldconfocalopticalcoherencetomographyforthediagnosisofskincarcinomas AT puigsusanna diagnosticaccuracyoflinefieldconfocalopticalcoherencetomographyforthediagnosisofskincarcinomas AT perrotjeanluc diagnosticaccuracyoflinefieldconfocalopticalcoherencetomographyforthediagnosisofskincarcinomas AT rubegnipietro diagnosticaccuracyoflinefieldconfocalopticalcoherencetomographyforthediagnosisofskincarcinomas |