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Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas

Line-field confocal optical coherence tomography (LC-OCT) is a new, noninvasive imaging technique for the diagnosis of skin cancers. A total of 243 benign (54%) and malignant (46%) skin lesions were consecutively enrolled from 27 August 2020, to 6 October 2021 at the Dermatology Department of the Un...

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Autores principales: Cinotti, Elisa, Brunetti, Tullio, Cartocci, Alessandra, Tognetti, Linda, Suppa, Mariano, Malvehy, Josep, Perez-Anker, Javiera, Puig, Susanna, Perrot, Jean Luc, Rubegni, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914674/
https://www.ncbi.nlm.nih.gov/pubmed/36766466
http://dx.doi.org/10.3390/diagnostics13030361
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author Cinotti, Elisa
Brunetti, Tullio
Cartocci, Alessandra
Tognetti, Linda
Suppa, Mariano
Malvehy, Josep
Perez-Anker, Javiera
Puig, Susanna
Perrot, Jean Luc
Rubegni, Pietro
author_facet Cinotti, Elisa
Brunetti, Tullio
Cartocci, Alessandra
Tognetti, Linda
Suppa, Mariano
Malvehy, Josep
Perez-Anker, Javiera
Puig, Susanna
Perrot, Jean Luc
Rubegni, Pietro
author_sort Cinotti, Elisa
collection PubMed
description Line-field confocal optical coherence tomography (LC-OCT) is a new, noninvasive imaging technique for the diagnosis of skin cancers. A total of 243 benign (54%) and malignant (46%) skin lesions were consecutively enrolled from 27 August 2020, to 6 October 2021 at the Dermatology Department of the University Hospital of Siena, Italy. Dermoscopic- and LC-OCT-based diagnoses were given by an expert dermatologist and compared with the ground truth. Considering all types of malignant skin tumours (79 basal cell carcinomas (BCCs), 22 squamous cell carcinomas, and 10 melanomas), a statistically significant increase (p = 0.013) in specificity was observed from dermoscopy (0.73, CI 0.64–0.81) to LC-OCT (0.87, CI 0.79–0.93) while sensitivity was the same with the two imaging techniques (0.95 CI 0.89–0.98 for dermoscopy and 0.95 CI 0.90–0.99 for LC-OCT). The increase in specificity was mainly driven by the ability of LC-OCT to differentiate BCCs from other diagnoses. In conclusion, our real-life study showed that LC-OCT can play an important role in helping the noninvasive diagnosis of malignant skin neoplasms and especially of BCCs. LC-OCT could be positioned after the dermoscopic examination, to spare useless biopsy of benign lesions without decreasing sensitivity.
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spelling pubmed-99146742023-02-11 Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas Cinotti, Elisa Brunetti, Tullio Cartocci, Alessandra Tognetti, Linda Suppa, Mariano Malvehy, Josep Perez-Anker, Javiera Puig, Susanna Perrot, Jean Luc Rubegni, Pietro Diagnostics (Basel) Article Line-field confocal optical coherence tomography (LC-OCT) is a new, noninvasive imaging technique for the diagnosis of skin cancers. A total of 243 benign (54%) and malignant (46%) skin lesions were consecutively enrolled from 27 August 2020, to 6 October 2021 at the Dermatology Department of the University Hospital of Siena, Italy. Dermoscopic- and LC-OCT-based diagnoses were given by an expert dermatologist and compared with the ground truth. Considering all types of malignant skin tumours (79 basal cell carcinomas (BCCs), 22 squamous cell carcinomas, and 10 melanomas), a statistically significant increase (p = 0.013) in specificity was observed from dermoscopy (0.73, CI 0.64–0.81) to LC-OCT (0.87, CI 0.79–0.93) while sensitivity was the same with the two imaging techniques (0.95 CI 0.89–0.98 for dermoscopy and 0.95 CI 0.90–0.99 for LC-OCT). The increase in specificity was mainly driven by the ability of LC-OCT to differentiate BCCs from other diagnoses. In conclusion, our real-life study showed that LC-OCT can play an important role in helping the noninvasive diagnosis of malignant skin neoplasms and especially of BCCs. LC-OCT could be positioned after the dermoscopic examination, to spare useless biopsy of benign lesions without decreasing sensitivity. MDPI 2023-01-18 /pmc/articles/PMC9914674/ /pubmed/36766466 http://dx.doi.org/10.3390/diagnostics13030361 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cinotti, Elisa
Brunetti, Tullio
Cartocci, Alessandra
Tognetti, Linda
Suppa, Mariano
Malvehy, Josep
Perez-Anker, Javiera
Puig, Susanna
Perrot, Jean Luc
Rubegni, Pietro
Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas
title Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas
title_full Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas
title_fullStr Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas
title_full_unstemmed Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas
title_short Diagnostic Accuracy of Line-Field Confocal Optical Coherence Tomography for the Diagnosis of Skin Carcinomas
title_sort diagnostic accuracy of line-field confocal optical coherence tomography for the diagnosis of skin carcinomas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9914674/
https://www.ncbi.nlm.nih.gov/pubmed/36766466
http://dx.doi.org/10.3390/diagnostics13030361
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