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SARS-CoV-2 Infection in Pregnancy: Clues and Proof of Adverse Outcomes

Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) represents one of the most threatening viral infections in the last decade. Amongst susceptible individuals, infected pregnant women might be predisposed to severe complications. Despite the extensive interest in SARS-CoV-2 res...

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Autores principales: Sessa, Rosa, Filardo, Simone, Masciullo, Luisa, Di Pietro, Marisa, Angeloni, Antonio, Brandolino, Gabriella, Brunelli, Roberto, D’Alisa, Rossella, Viscardi, Maria Federica, Anastasi, Emanuela, Porpora, Maria Grazia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915124/
https://www.ncbi.nlm.nih.gov/pubmed/36767980
http://dx.doi.org/10.3390/ijerph20032616
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author Sessa, Rosa
Filardo, Simone
Masciullo, Luisa
Di Pietro, Marisa
Angeloni, Antonio
Brandolino, Gabriella
Brunelli, Roberto
D’Alisa, Rossella
Viscardi, Maria Federica
Anastasi, Emanuela
Porpora, Maria Grazia
author_facet Sessa, Rosa
Filardo, Simone
Masciullo, Luisa
Di Pietro, Marisa
Angeloni, Antonio
Brandolino, Gabriella
Brunelli, Roberto
D’Alisa, Rossella
Viscardi, Maria Federica
Anastasi, Emanuela
Porpora, Maria Grazia
author_sort Sessa, Rosa
collection PubMed
description Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) represents one of the most threatening viral infections in the last decade. Amongst susceptible individuals, infected pregnant women might be predisposed to severe complications. Despite the extensive interest in SARS-CoV-2 research, the clinical course of maternal infection, the vertical transmission and the neonatal outcomes have not been completely understood yet. The aim of our study was to investigate the association between SARS-CoV-2 infection, obstetric outcomes and vertical transmission. Methods: A prospective observational study was performed, enrolling unvaccinated pregnant patients positive for SARS-CoV-2 (cases) and matched with uninfected pregnant women (controls). Maternal and neonatal nasopharyngeal swabs, maternal and cord blood, amniotic fluid and placenta tissue samples were collected; blood samples were tested for anti-S and anti-N antibodies, and histologic examination of placental tissues was performed. Results: The cases showed a significant association with the development of some obstetric complications, such as intrauterine growth restriction and pregnancy-associated hypothyroidism and diabetes, as compared to controls; their newborns were more likely to have a low birth weight and an arterial umbilical pH less than 7. The viral genome was detected in maternal and cord blood and placental samples in six cases. Conclusions: Pregnant women positive for SARS-CoV-2 infection are more likely to develop severe obstetric outcomes; their newborns could have a low birth weight and arterial pH. Vertical transmission seems a rare event, and further investigation is strongly needed.
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spelling pubmed-99151242023-02-11 SARS-CoV-2 Infection in Pregnancy: Clues and Proof of Adverse Outcomes Sessa, Rosa Filardo, Simone Masciullo, Luisa Di Pietro, Marisa Angeloni, Antonio Brandolino, Gabriella Brunelli, Roberto D’Alisa, Rossella Viscardi, Maria Federica Anastasi, Emanuela Porpora, Maria Grazia Int J Environ Res Public Health Article Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) represents one of the most threatening viral infections in the last decade. Amongst susceptible individuals, infected pregnant women might be predisposed to severe complications. Despite the extensive interest in SARS-CoV-2 research, the clinical course of maternal infection, the vertical transmission and the neonatal outcomes have not been completely understood yet. The aim of our study was to investigate the association between SARS-CoV-2 infection, obstetric outcomes and vertical transmission. Methods: A prospective observational study was performed, enrolling unvaccinated pregnant patients positive for SARS-CoV-2 (cases) and matched with uninfected pregnant women (controls). Maternal and neonatal nasopharyngeal swabs, maternal and cord blood, amniotic fluid and placenta tissue samples were collected; blood samples were tested for anti-S and anti-N antibodies, and histologic examination of placental tissues was performed. Results: The cases showed a significant association with the development of some obstetric complications, such as intrauterine growth restriction and pregnancy-associated hypothyroidism and diabetes, as compared to controls; their newborns were more likely to have a low birth weight and an arterial umbilical pH less than 7. The viral genome was detected in maternal and cord blood and placental samples in six cases. Conclusions: Pregnant women positive for SARS-CoV-2 infection are more likely to develop severe obstetric outcomes; their newborns could have a low birth weight and arterial pH. Vertical transmission seems a rare event, and further investigation is strongly needed. MDPI 2023-02-01 /pmc/articles/PMC9915124/ /pubmed/36767980 http://dx.doi.org/10.3390/ijerph20032616 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sessa, Rosa
Filardo, Simone
Masciullo, Luisa
Di Pietro, Marisa
Angeloni, Antonio
Brandolino, Gabriella
Brunelli, Roberto
D’Alisa, Rossella
Viscardi, Maria Federica
Anastasi, Emanuela
Porpora, Maria Grazia
SARS-CoV-2 Infection in Pregnancy: Clues and Proof of Adverse Outcomes
title SARS-CoV-2 Infection in Pregnancy: Clues and Proof of Adverse Outcomes
title_full SARS-CoV-2 Infection in Pregnancy: Clues and Proof of Adverse Outcomes
title_fullStr SARS-CoV-2 Infection in Pregnancy: Clues and Proof of Adverse Outcomes
title_full_unstemmed SARS-CoV-2 Infection in Pregnancy: Clues and Proof of Adverse Outcomes
title_short SARS-CoV-2 Infection in Pregnancy: Clues and Proof of Adverse Outcomes
title_sort sars-cov-2 infection in pregnancy: clues and proof of adverse outcomes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915124/
https://www.ncbi.nlm.nih.gov/pubmed/36767980
http://dx.doi.org/10.3390/ijerph20032616
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