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Time of Day and Chronotype-Dependent Synchrony Effects Exercise-Induced Reduction in Migraine Load: A Pilot Cross-Over Randomized Trial

Migraines are the most common cause of chronic pain. Effective, non-pharmacological strategies to reduce migraine load, like exercise, are needed, but it is unclear how exercise timing and chronotype modulate the effects. We sought to determine the effects of time-of-day of exercise, and synchrony w...

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Autores principales: Malek, Elias M., Navalta, James W., McGinnis, Graham R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915413/
https://www.ncbi.nlm.nih.gov/pubmed/36767448
http://dx.doi.org/10.3390/ijerph20032083
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author Malek, Elias M.
Navalta, James W.
McGinnis, Graham R.
author_facet Malek, Elias M.
Navalta, James W.
McGinnis, Graham R.
author_sort Malek, Elias M.
collection PubMed
description Migraines are the most common cause of chronic pain. Effective, non-pharmacological strategies to reduce migraine load, like exercise, are needed, but it is unclear how exercise timing and chronotype modulate the effects. We sought to determine the effects of time-of-day of exercise, and synchrony with one’s chronotype, on migraine load. We performed a pilot cross-over randomized trial where participants with chronic migraine completed two one-month exercise interventions, consisting of either morning exercise (before 09:00 a.m.) or evening exercise (after 7:00 p.m.) in a randomized repeated measures cross-over design (Clinical Trial #NCT04553445). Synchrony was determined by exercise time and chronotype (i.e., a morning type participant exercising in the morning is ‘in-sync,’ while an evening type participant exercising in the morning is ‘out-of-sync’). Migraine burden, and anthropometric assessment occurred before and after each month of exercise. Data was analyzed using repeated measures ANOVA with significance accepted at p < 0.05. When comparing morning and evening exercise, there was no significant improvements in any migraine-related parameters. However, when comparing in-sync and out-of-sync exercise, we found that migraine burden was only improved following in-sync exercise, while no benefits were seen in out-of-sync exercise. Our data suggests that exercise timing has limited impact, but synchrony with chronotype may be essential to decrease migraine load in chronic migraineurs.
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spelling pubmed-99154132023-02-11 Time of Day and Chronotype-Dependent Synchrony Effects Exercise-Induced Reduction in Migraine Load: A Pilot Cross-Over Randomized Trial Malek, Elias M. Navalta, James W. McGinnis, Graham R. Int J Environ Res Public Health Article Migraines are the most common cause of chronic pain. Effective, non-pharmacological strategies to reduce migraine load, like exercise, are needed, but it is unclear how exercise timing and chronotype modulate the effects. We sought to determine the effects of time-of-day of exercise, and synchrony with one’s chronotype, on migraine load. We performed a pilot cross-over randomized trial where participants with chronic migraine completed two one-month exercise interventions, consisting of either morning exercise (before 09:00 a.m.) or evening exercise (after 7:00 p.m.) in a randomized repeated measures cross-over design (Clinical Trial #NCT04553445). Synchrony was determined by exercise time and chronotype (i.e., a morning type participant exercising in the morning is ‘in-sync,’ while an evening type participant exercising in the morning is ‘out-of-sync’). Migraine burden, and anthropometric assessment occurred before and after each month of exercise. Data was analyzed using repeated measures ANOVA with significance accepted at p < 0.05. When comparing morning and evening exercise, there was no significant improvements in any migraine-related parameters. However, when comparing in-sync and out-of-sync exercise, we found that migraine burden was only improved following in-sync exercise, while no benefits were seen in out-of-sync exercise. Our data suggests that exercise timing has limited impact, but synchrony with chronotype may be essential to decrease migraine load in chronic migraineurs. MDPI 2023-01-23 /pmc/articles/PMC9915413/ /pubmed/36767448 http://dx.doi.org/10.3390/ijerph20032083 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Malek, Elias M.
Navalta, James W.
McGinnis, Graham R.
Time of Day and Chronotype-Dependent Synchrony Effects Exercise-Induced Reduction in Migraine Load: A Pilot Cross-Over Randomized Trial
title Time of Day and Chronotype-Dependent Synchrony Effects Exercise-Induced Reduction in Migraine Load: A Pilot Cross-Over Randomized Trial
title_full Time of Day and Chronotype-Dependent Synchrony Effects Exercise-Induced Reduction in Migraine Load: A Pilot Cross-Over Randomized Trial
title_fullStr Time of Day and Chronotype-Dependent Synchrony Effects Exercise-Induced Reduction in Migraine Load: A Pilot Cross-Over Randomized Trial
title_full_unstemmed Time of Day and Chronotype-Dependent Synchrony Effects Exercise-Induced Reduction in Migraine Load: A Pilot Cross-Over Randomized Trial
title_short Time of Day and Chronotype-Dependent Synchrony Effects Exercise-Induced Reduction in Migraine Load: A Pilot Cross-Over Randomized Trial
title_sort time of day and chronotype-dependent synchrony effects exercise-induced reduction in migraine load: a pilot cross-over randomized trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915413/
https://www.ncbi.nlm.nih.gov/pubmed/36767448
http://dx.doi.org/10.3390/ijerph20032083
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