A comprehensive survey of coronaviral main protease active site diversity in 3D: Identifying and analyzing drug discovery targets in search of broad specificity inhibitors for the next coronavirus pandemic

Although the rapid development of therapeutic responses to combat SARS-CoV-2 represents a great human achievement, it also demonstrates untapped potential for advanced pandemic preparedness. Cross-species efficacy against multiple human coronaviruses by the main protease (MPro) inhibitor nirmatrelvi...

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Detalles Bibliográficos
Autores principales: Lubin, Joseph H., Martinusen, Samantha G., Zardecki, Christine, Olivas, Cassandra, Bacorn, Mickayla, Balogun, MaryAgnes, Slaton, Ethan W., Wu, Amy Wu, Sakeer, Sarah, Hudson, Brian P., Denard, Carl A., Burley, Stephen K., Khare, Sagar D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915488/
https://www.ncbi.nlm.nih.gov/pubmed/36778399
http://dx.doi.org/10.1101/2023.01.30.526101

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