Hypermetabolism in mice carrying a near complete human chromosome 21

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The consequences of aneuploidy have traditionally been studied in cell and animal models in which the extrachromosomal DNA is from the same species. Here, we explore a fundamental question concerning the impact of aneuploidy on systemic metabolism using a non-mosaic transchromosomic mouse model (TcM...

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Detalles Bibliográficos
Autores principales: Sarver, Dylan C., Xu, Cheng, Rodriguez, Susana, Aja, Susan, Jaffe, Andrew E., Gao, Feng J., Delannoy, Michael, Periasamy, Muthu, Kazuki, Yasuhiro, Oshimura, Mitsuo, Reeves, Roger H., Wong, G. William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915508/
https://www.ncbi.nlm.nih.gov/pubmed/36778465
http://dx.doi.org/10.1101/2023.01.30.526183
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