EMBER multi-dimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains

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In neurodegenerative diseases proteins fold into amyloid structures with distinct conformations (strains) that are characteristic of different diseases. However, there is a need to rapidly identify amyloid conformations in situ. Here we use machine learning on the full information available in fluor...

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Detalles Bibliográficos
Autores principales: Yang, Hyunjun, Yuan, Peng, Wu, Yibing, Shi, Marie, Caro, Christoffer D., Tengeiji, Atsushi, Yamanoi, Shigeo, Inoue, Masahiro, DeGrado, William F., Condello, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915571/
https://www.ncbi.nlm.nih.gov/pubmed/36778268
http://dx.doi.org/10.1101/2023.02.01.526692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9915571/
https://www.ncbi.nlm.nih.gov/pubmed/36778268
http://dx.doi.org/10.1101/2023.02.01.526692

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